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  4. Recombinant Human DnaJ homolog subfamily C member 21 (DNAJC21)

Recombinant Human DnaJ homolog subfamily C member 21 (DNAJC21)

  • 中文名称：
    人DNAJC21重组蛋白
  • 货号：
    CSB-YP704871HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DNAJC21重组蛋白
  • 货号：
    CSB-EP704871HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DNAJC21重组蛋白
  • 货号：
    CSB-EP704871HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DNAJC21重组蛋白
  • 货号：
    CSB-BP704871HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DNAJC21重组蛋白
  • 货号：
    CSB-MP704871HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DNAJC21
  • Uniprot No.：
  • 别名：
    DJC21_HUMAN; DnaJ homolog subfamily A member 5; DnaJ homolog subfamily C member 21; DNAJA5; dnajc21; GS3; JJJ1; Protein GS3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-531
  • 氨基酸序列
    MKCHYEALGV RRDASEEELK KAYRKLALKW HPDKNLDNAA EAAEQFKLIQ AAYDVLSDPQ ERAWYDNHRE ALLKGGFDGE YQDDSLDLLR YFTVTCYSGY GDDEKGFYTV YRNVFEMIAK EELESVLEEE VDDFPTFGDS QSDYDTVVHP FYAYWQSFCT QKNFAWKEEY DTRQASNRWE KRAMEKENKK IRDKARKEKN ELVRQLVAFI RKRDKRVQAH RKLVEEQNAE KARKAEEMRR QQKLKQAKLV EQYREQSWMT MANLEKELQE MEARYEKEFG DGSDENEMEE HELKDEEDGK DSDEAEDAEL YDDLYCPACD KSFKTEKAMK NHEKSKKHRE MVALLKQQLE EEEENFSRPQ IDENPLDDNS EEEMEDAPKQ KLSKKQKKKK QKPAQNYDDN FNVNGPGEGV KVDPEDTNLN QDSAKELEDS PQENVSVTEI IKPCDDPKSE AKSVPKPKGK KTKDMKKPVR VPAEPQTMSV LISCTTCHSE FPSRNKLFDH LKATGHARAP SSSSLNSATS SQSKKEKRKN R
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May act as a co-chaperone for HSP70. May play a role in ribosomal RNA (rRNA) biogenesis, possibly in the maturation of the 60S subunit. Binds the precursor 45S rRNA.
  • 基因功能参考文献：
    1. Biallelic mutations in DNAJC21 cause Shwachman-Diamond syndrome. PMID: 28062395
    2. findings demonstrate that mutations in DNAJC21 cause a cancer-prone bone marrow failure syndrome due to corruption of early nuclear rRNA biogenesis and late cytoplasmic maturation of the 60S subunit PMID: 27346687
  • 相关疾病：
    Bone marrow failure syndrome 3 (BMFS3)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Nucleus, nucleolus.
  • 组织特异性：
    Expressed in brain, placenta, kidney and pancreas.
  • 数据库链接：

    HGNC: 27030

    OMIM: 617048

    KEGG: hsa:134218

    UniGene: Hs.131887