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  4. Recombinant Human Dual specificity protein phosphatase 23 (DUSP23)

Recombinant Human Dual specificity protein phosphatase 23 (DUSP23)

  • 货号：
    CSB-YP871584HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP871584HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP871584HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP871584HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP871584HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DUSP23
  • Uniprot No.：
  • 别名：
    Dual specificity phosphatase 23; Dual specificity protein phosphatase 23; DUS23_HUMAN; Dusp23; DUSP25; EC 3.1.3.16; EC 3.1.3.48; FLJ20442; LDP 3; LDP-3; LDP3; Low molecular mass dual specificity phosphatase 3; MOSP; RP11-190A12.1; VH1 like member Z; VH1 like phosphatase Z ; VH1-like phosphatase Z; VHZ
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-150
  • 氨基酸序列
    MGVQPPNFSW VLPGRLAGLA LPRLPAHYQF LLDLGVRHLV SLTERGPPHS DSCPGLTLHR LRIPDFCPPA PDQIDRFVQI VDEANARGEA VGVHCALGFG RTGTMLACYL VKERGLAAGD AIAEIRRLRP GSIETYEQEK AVFQFYQRTK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Protein phosphatase that mediates dephosphorylation of proteins phosphorylated on Tyr and Ser/Thr residues. In vitro, it can dephosphorylate p44-ERK1 (MAPK3) but not p54 SAPK-beta (MAPK10) in vitro. Able to enhance activation of JNK and p38 (MAPK14).
  • 基因功能参考文献：
    1. this study shows that DUSP23 mRNA levels in CD4+ T cells are higher in the systemic lupus erythematosus patients PMID: 27737517
    2. The upregulation of VHZ levels in primary human cancers supports the clinical relevance of this protein in cancers PMID: 20509867
    3. DUSP23 showed distinctive phosphatase activity toward p-nitrophenyl phosphate, as well as oligopeptides containing phospho-tyrosine and phospho-threonine residues. Furthermore, DUSP23 could dephosphorylate p44ERK1 but not p38 and p54SAPKbeta in vitro PMID: 15147733
    4. the smallest active protein-tyrosine phosphatase yet (only 16 kDa) belongs to the group of small Vaccinia virus VH1-related dual specific phosphatases; gene is located on human chromosome 1q23.1 and consists of only two coding exons PMID: 15201283
  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Note=Mainly cytosolic. Also nuclear.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
  • 组织特异性：
    Widely expressed. Highly expressed in spleen, prostate, colon, adrenal gland, mammary gland, thyroid and trachea. Expressed at lower level in uterus, small intestine, bladder, bone marrow, brain, spinal cord and stomach.
  • 数据库链接：

    HGNC: 21480

    KEGG: hsa:54935

    STRING: 9606.ENSP00000357087

    UniGene: Hs.425801