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  4. Recombinant Human ELMO domain-containing protein 2 (ELMOD2)

Recombinant Human ELMO domain-containing protein 2 (ELMOD2)

  • 货号：
    CSB-YP815588HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP815588HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP815588HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP815588HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP815588HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ELMOD2
  • Uniprot No.：
  • 别名：
    9830169G11Rik; ELMD2_HUMAN; ELMO domain containing 2; ELMO domain containing protein 2; ELMO domain-containing protein 2; ELMO/CED 12 domain containing 2; ELMOD2; MGC10084
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-293
  • 氨基酸序列
    MFISLWEFFY GHFFRFWMKW LLRQMTGKCE LQRIFDTYVG AQRTHRIENS LTYSKNKVLQ KATHVVQSEV DKYVDDIMKE KNINPEKDAS FKICMKMCLL QITGYKQLYL DVESVRKRPY DSDNLQHEEL LMKLWNLLMP TKKLNARISK QWAEIGFQGD DPKTDFRGMG ILGLINLVYF SENYTSEAHQ ILSRSNHPKL GYSYAIVGIN LTEMAYSLLK SEALKFHLYN LVPGIPTMEH FHQFYCYLVY EFDKFWFEEE PESIMYFNLY REKFHEKIKG LLLDCNVALT LKV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses.
  • 基因功能参考文献：
    1. The non-opioid sigma-1 receptor (S1R) was identified as a novel effector of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 resulted in loss of GAP activity. PMID: 24616099
    2. TLR3 pathway is dependent on ELMOD2 PMID: 19966137
    3. results suggest ELMOD2 as a novel candidate gene for susceptibility in familial idiopathic pulmonary fibrosis PMID: 16773575
    4. Results describe the purification from bovine testis of an Arl2 GAP and its identity as ELMOD2, a protein with no previously described function. PMID: 17452337
  • 组织特异性：
    Alveolar cells (morphologically type II cells) and alveolar macrophages (at protein level). Expressed in brain, colon, heart, kidney, liver, lung, muscle, placenta, small intestine, spleen, stomach and testis. In lung it is expressed in alveolar macrophag
  • 数据库链接：

    HGNC: 28111

    OMIM: 610196

    KEGG: hsa:255520

    STRING: 9606.ENSP00000326342

    UniGene: Hs.450105