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  4. Recombinant Human Endogenous retrovirus group K member 6 Env polyprotein (ERVK-6), partial

Recombinant Human Endogenous retrovirus group K member 6 Env polyprotein (ERVK-6), partial

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  • 中文名称：
    人ERVK-6重组蛋白
  • 货号：
    CSB-EP724336HU
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP724336HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) ERVK-6.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP724336HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) ERVK-6.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    ERVK-6
  • Uniprot No.：
  • 别名：
    ERVK-6; ERVK6Endogenous retrovirus group K member 6 Env polyprotein; EnvK2 protein; Envelope polyprotein; HERV-K(C7) envelope protein; HERV-K(HML-2.HOM) envelope protein; HERV-K108 envelope protein; HERV-K_7p22.1 provirus ancestral Env polyprotein) [Cleaved into: Surface protein; SU); Transmembrane protein; TM)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Extracellular Domain
  • 来源：
    E.coli
  • 分子量：
    77.5kDa
  • 表达区域：
    90-632aa
  • 氨基酸序列
    LPMPAGAAAANYTYWAYVPFPPLIRAVTWMDNPTEVYVNDSVWVPGPIDDRCPAKPEEEGMMINISIGYHYPPICLGRAPGCLMPAVQNWLVEVPTVSPICRFTYHMVSGMSLRPRVNYLQDFSYQRSLKFRPKGKPCPKEIPKESKNTEVLVWEECVANSAVILQNNEFGTIIDWAPRGQFYHNCSGQTQSCPSAQVSPAVDSDLTESLDKHKHKKLQSFYPWEWGEKGISTPRPKIVSPVSGPEHPELWRLTVASHHIRIWSGNQTLETRDRKPFYTIDLNSSLTVPLQSCVKPPYMLVVGNIVIKPDSQTITCENCRLLTCIDSTFNWQHRILLVRAREGVWIPVSMDRPWEASPSVHILTEVLKGVLNRSKRFIFTLIAVIMGLIAVTATAAVAGVALHSSVQSVNFVNDWQKNSTRLWNSQSSIDQKLANQINDLRQTVIWMGDRLMSLEHRFQLQCDWNTSDFCITPQIYNESEHHWDMVRRHLQGREDNLTLDISKLKEQIFEASKAHLNLVPGTEAIAGVADGLANLNPVTWVKT
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    Like all recombinant proteins, this Recombinant Human ERVK-6 protein was encoded by recombinant DNA. The recombinant DNA was introduced to a plasmid in which the gene of ERVK-6 was cloned downstream of a promoter region. When the plasmid was introduced to the cells of E.coli, the E.coli’s own protein synthesis pathways would then result in the expression of the ERVK-6 protein. And the next step was protein purification. The purity of this recombinant protein is 90%+ determined by SDS-PAGE.

    ERVK-6 is known as HERV-K, which has been considered as a supergroup of viruses. One of the subtypes, termed HML-2, seems to be the most active and hence, it is the best studied. Aberrant expression of HML-2 in adult tissues has been associated with certain types of cancer and with neurodegenerative diseases. Interestingly, HML-2 can also form viral-like particles, which have been detected in various cells, particularly teratocarcinomas and melanomas. . Although these viral-like particles are considered noninfectious, two independent research groups have demonstrated that the consensus sequence of HML-2 provirus can produce infectious particles. The involvement of HML-2 in pathological conditions, especially in malignancies, has been the focus of numerous publications. However, expression profiles of healthy tissues such as brain, heart, peripheral blood mononuclear cells (PBMCs), lung, liver, and breast indicate that several HML-2 proviruses are transcriptionally active, although the magnitude of expression in most healthy tissues is low. Since increased activation of HML-2 has been associated with several pathologies, it raises the question of whether these genes can be silenced to affect the outcome of these diseases.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its original fusogenic properties.; SU mediates receptor recognition.; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane.
  • 亚细胞定位：
    [Transmembrane protein]: Cell membrane; Single-pass type I membrane protein.; [Surface protein]: Cell membrane; Peripheral membrane protein.; [Endogenous retrovirus group K member 6 Env polyprotein]: Virion.
  • 蛋白家族：
    Beta type-B retroviral envelope protein family, HERV class-II K(HML-2) env subfamily
  • 组织特异性：
    Expressed in testis, and peripheral blood lymphocytes.
  • 数据库链接：

    HGNC: 13915

    OMIM: 605626