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  4. Recombinant Human Endosialin (CD248), partial

Recombinant Human Endosialin (CD248), partial

  • 中文名称：
    Recombinant Human Endosialin(CD248),partial,Yeast
  • 货号：
    CSB-YP875727HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Endosialin(CD248),partial,Yeast
  • 货号：
    CSB-EP875727HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Endosialin(CD248),partial,Yeast
  • 货号：
    CSB-EP875727HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Endosialin(CD248),partial,Yeast
  • 货号：
    CSB-BP875727HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Endosialin(CD248),partial,Yeast
  • 货号：
    CSB-MP875727HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    CD248
  • Uniprot No.：
  • 别名：
    CD164 sialomucin like 1; CD164L1; CD248; CD248 antigen endosialin; CD248 molecule endosialin; CD248_HUMAN; Endosialin; TEM 1; TEM1; Tumor endothelial marker 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in tumor angiogenesis.
  • 基因功能参考文献：
    1. These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation PMID: 28671670
    2. Data show that podoplanin (PDPN), CD106 (VCAM-1) and CD248 protein were increased in diseased compared to healthy tendon cells. PMID: 28122639
    3. the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer PMID: 27635044
    4. Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis. PMID: 28126825
    5. Tumour cell endosialin expression was seen in 89% of undifferentiated pleomorphic sarcomas, 77% of adult fibrosarcomas/spindle cell sarcomas, 62% of synovial sarcomas, 51% of leiomyosarcomas and 31% of rhabdomyosarcomas. PMID: 27434038
    6. CD248 overexpression is possibly involved in the pathogenesis of IPF and it has potential as a disease severity marker. PMID: 27080864
    7. TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer PMID: 26336878
    8. MORAb-004 reduced CD248 on pericytes, impaired tumor microvasculature maturation and ultimately suppressed tumor development. PMID: 26327620
    9. The s show that endosialin, a C-type lectin, expressed in the liver exclusively by HSC and portal fibroblasts, is upregulated in liver fibrosis in mouse and man. PMID: 25680861
    10. The genes CD248, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies. PMID: 24716914
    11. new monoclonal antibodies described in this paper are domain-specific and represent important reagents for the study of functional contributions of extracellular endosialin domains PMID: 22824847
    12. [review] CD248 is a C-type lectin-like domain-containing cell surface glycoprotein that is expressed by stromal cells of proliferating tissues during embryogenesis and postnatally in tumors and inflammatory lesions. PMID: 22206249
    13. CD248 defines a subset of stromal cells, including but not limited to some myofibroblasts, linked to albuminuria and tubulointerstitial damage during tissue remodeling in CKD. PMID: 21490589
    14. endosialin can be detected in advanced sarcoma PMID: 21537839
    15. Endosialin expression may be involved in the progression of rectal cancers. PMID: 21362178
    16. Results provide evidence for a TEM-1-dependent signal pathway that controls proliferation of pericytes. PMID: 20484976
    17. TEM1/endosialin was induced in the vasculature of high-grade brain tumors where its expression was inversely correlated with patient age. PMID: 19948061
    18. Endosialin colocalized with thrombomodulin, suggesting the proteins may have complementary functions in tumor progression. PMID: 15624764
    19. Endosialin is a marker of stromal fibroblasts and is not selectively expressed on tumor endothelium. PMID: 15862292
    20. results pinpoint to a molecular mechanism by which expression of endosialin/TEM1 in the tumor stroma and endothelium may support tumor progression and invasion PMID: 17986615
    21. experiments unambiguously demonstrate that endosialin is expressed by tumor-associated myofibroblasts & mural cells & not by endothelial cells; results validate endosialin as marker of tumor-associated myofibroblasts & tumor vessel-associated mural cells PMID: 18187565
    22. endosialin is not expressed in normal human adult brain but is strongly upregulated in the angiogenic vasculature of all high-grade glioma specimens examined PMID: 18192970
    23. identified extracellular endosialin ligands and identified Mac-2 BP/90K as a specific interaction partner PMID: 18490383
    24. expression of TEM1 or endosialin (CD248) and other TEM has been discovered in a population of vascular endothelial growth factor receptor 2+/CD31+/CD45-/VE-cadherin+ EPC derived from human CD133+/CD34+ cells PMID: 18723498
    25. endosialin is strongly expressed by pericytes during periods of active angiogenesis during embryonic and tumor development PMID: 18761022
    26. These findings elucidate important aspects of endosialin gene regulation PMID: 18813310

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of
  • 数据库链接：

    HGNC: 18219

    OMIM: 606064

    KEGG: hsa:57124

    STRING: 9606.ENSP00000308117

    UniGene: Hs.195727