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  4. Recombinant Human Endothelin B receptor (EDNRB), partial

Recombinant Human Endothelin B receptor (EDNRB), partial

  • 货号：
    CSB-YP007404HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007404HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007404HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007404HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007404HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    EDNRB; ETRB; Endothelin receptor type B; ET-B; ET-BR; Endothelin receptor non-selective type
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. the joint effect of polymorphisms of EDNRB and NOS3 on diabetic retinopathy risk was greater than the individual effect of each polymorphism in the analyzed genetic models PMID: 28817788
    2. the results suggest that aberrant expression of Gli1 serves a role in HSCR by targeting EDNRB. PMID: 29484400
    3. Endothelin B receptor (ETBR) is overexpressed in glioblastoma and may be a prognostic marker and useful target for treating cancer patients. PMID: 29409474
    4. our current findings suggest that human neutrophils display functional ETB receptors with calcium signaling capability, leading to accentuated adhesion to the endothelium. PMID: 28385784
    5. ETBR function contributes to diminished endothelium-dependent dilation in previously preeclamptic women. PMID: 29042489
    6. An IL2-targeted antibody failed to detect transfected ETB in HEK293 cultures. In contrast, the NT-targeted antibody accurately detected transfected ETB in HEK293 cultures by labeling a 37-kDa band. PMID: 25232999
    7. This study concluded that ETB receptors mediate vasodilation in young women, but this effect is lost after menopause. PMID: 28438762
    8. Our results suggest that EDNRB rs5351 single nucleotide polymorphism is a strong independent predictor of essential hypertension in men of Tatar ethnic origin. PMID: 28350619
    9. No rare EDNRB variants were identified among 57 patients with Hirschsprung disease. PMID: 26395553
    10. Taking into account that the cohort we screened was deprived of patients previously found mutated in MITF (about 15%) and SOX10 (another 15%), our 8% mutation rate indicates that EDNRB heterozygous mutations represent about 5%-6% of all WS2, making it the third gene of this subtype. PMID: 28236341
    11. The high level of ETBR expression observed in CMS patients compared to healthy controls suggests that the cerebral hypoxia diastolic reaction is possible due to ETBR, rather than ET-1 itself. PMID: 27485004
    12. crystal structures of human endothelin type B receptor in the ligand-free form and in complex with the endogenous agonist endothelin-1 PMID: 27595334
    13. Wnt-dependent EdnrB signaling can rescue the defects in melanocyte regeneration caused by Mc1R loss. PMID: 27134165
    14. This article is focused on the engineering, expression, purification, and characterization of the endothelin receptor B for subsequent structural and functional studies PMID: 27193723
    15. Serum EDNRB hypermethylation is a highly specific but not sensitive serum biomarker for HNSCC PMID: 24995714
    16. High Endothelin B receptor expression is associated with malignant gliomas. PMID: 26645886
    17. EDNRB plays a key role in hypoxia tolerance PMID: 26240367
    18. The increased gene expression of MITF and EDNRB in UVB-exposed NHMs. PMID: 26030901
    19. culturing of reconstructed skin with microvascular endothelial cells led to increased skin pigmentation that could be prevented by inhibiting EDNRB PMID: 26308584
    20. Polymorphisms of the EDNRB gene may influence the susceptibility to obesity and can interact with plasma arsenic levels PMID: 25799405
    21. Cumulative effects of the RET and EDNRB genes contribute to long-segment and total colonic aganglionosis. PMID: 25638620
    22. Endothelin receptor B expression was significantly lower while higher staining grade was found in basal cell carcinoma rather than squamous cell carcinoma or psoriasis. PMID: 25946671
    23. Its expression by lymphoma and endothelial cells may mediate trafficking of tumor-infiltrated lymphocytes, which may explain the immune escape processes of primary central nervous system lymphomas. PMID: 25433721
    24. The results show that MitA can effectively be used to block ETBR mediated vasoconstriction as a supplement to an existing ischemic stroke therapy. PMID: 25479176
    25. Identification of heterozygous deletion of the entire EDNRB in a father and 2 children. Since heterozygous deletion was the only change identified in EDNRB, the family represents one of the few cases of autosomal dominant inheritance of Waardenburg type 4 PMID: 25118007
    26. The anti-EDNRB ADC combines well with BRAF and MEK inhibitors and could have therapeutic use in the majority of human melanoma cases. PMID: 24651527
    27. A novel stop mutation in the EDNRB gene was found in a family with Hirschsprung's disease associated with multiple sclerosis. PMID: 24726125
    28. No biologically significant correlation was observed in the ETBR immunohistochemistry of human pancreatic ductal adenocarcinoma sections PMID: 24549269
    29. There was no difference in EDNRB mRNA expression between reflux esophagitis, Barrett's esophagus, and controls. PMID: 23384184
    30. Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer. PMID: 24326135
    31. The endothelin B receptor was demonstrated to mediate the proliferation of oligodendroglioma cells according to an ERK-dependent mechanism. PMID: 24145738
    32. The -615 to -624 bp region is the key binding site of AP-1 in ETB receptor promoter and was found to be crucial for inducible ETB receptor expression. PMID: 24265756
    33. The levels of the EDNRB, HJURP and p60/CAF-1 proteins were strongly associated with overall survival in high-grade gliomas patients (p<0.001, p<0.001 and p=0.002, respectively), whereas the one of PDLI4 was not (P=0.11). PMID: 24039914
    34. Gene expression profiling for uveal melanoma may be obtained from patients who were previously treated with radiotherapy PMID: 24511587
    35. Endothelin receptor type B expression was correlated with several clinicopathological factors including tumor differentiation, tumor depth, and lymph node metastasis. PMID: 24357795
    36. EDNRB is generally accepted as a major gene for Hirschsprung's disease. PMID: 23579558
    37. Endothelin receptor type B is a novel pathway and therapeutic target for enhancing remyelination in multiple sclerosis. PMID: 23518706
    38. Expression of endothelin A and B receptors and endothelin-1 in the pulmonary arteries is significantly increased in failed Fontan patients. PMID: 21356562
    39. Data indicate that endothelin receptor B (EDNRB) overexpression facilitates intracranial melanoma growth. PMID: 22865454
    40. Our findings demonstrate that aldosterone modulates an ET(B) cysteinyl thiol redox switch to decrease pulmonary endothelium-derived NO(.) and promote pulmonary arterial hypertension. PMID: 22787113
    41. Loss of EDNRB is associated with metastasis in clear-cell renal cell carcinoma. PMID: 22213152
    42. results obtained give evidence of a possible participation of receptor for endothelin B in the pathogenesis of the itch in the dermatitis herpetiformis PMID: 22535604
    43. promoter hypermethylation of EDNRB gene is highly prevalent in gastric cancer PMID: 21264540
    44. In transgenic Ednrb-deficient mice, sacral crest-derived cells diminish in number from fetal to postnatal stages. PMID: 21858821
    45. Survival analysis shows that the ETB receptor high expression group had significantly shorter disease-free survival and overall survival rates than the low expression group. PMID: 21770857
    46. Attenuated ET-B receptor mediated vasodilatation during local skin warming compared to Controls. PMID: 21825025
    47. 3 novel mutations in EDNRB gene associated with Waardenburg-Shah syndrome (WS4) in Pakistani patients. PMID: 21547364
    48. No association of S305N EDNRB polymorphism with sporadic melanoma risk in the French or Italian populations, but there was an indication that EDNRB might be a melanoma-predisposing gene in French patients with a hereditary predisposition to melanoma. PMID: 21507037
    49. Endothelin type B receptor-mediated contractions of the cerebrovasculature are significantly reduced following inhibition of B-raf kinase. PMID: 21223556
    50. cigarette smoke extract induced ET(B) receptor overexpression by a feed forward mechanism mediated partly by ET release, promoting pulmonary artery endothelial cell dysfunction and attenuated by ET(B) receptor blockade, Rho kinase and ROS inhibition PMID: 20698855

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  • 相关疾病：
    Waardenburg syndrome 4A (WS4A); Hirschsprung disease 2 (HSCR2); ABCD syndrome (ABCDS)
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, Endothelin receptor subfamily, EDNRB sub-subfamily
  • 组织特异性：
    Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells.
  • 数据库链接：

    HGNC: 3180

    OMIM: 131244

    KEGG: hsa:1910

    STRING: 9606.ENSP00000366416

    UniGene: Hs.732046