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  4. Recombinant Human Fibroblast growth factor 20 (FGF20)

Recombinant Human Fibroblast growth factor 20 (FGF20)

  • 货号：
    CSB-YP008626HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008626HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008626HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008626HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008626HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FGF-20; Fgf20; FGF20_HUMAN; FGFK; Fibroblast growth factor 20; RHDA2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-211
  • 氨基酸序列
    MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR SKRHQKFTHF LPRPVDPERV PELYKDLLMY T
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Neurotrophic factor that regulates central nervous development and function.
  • 基因功能参考文献：
    1. Studied effect of recombinant human fibroblast growth factor 20 (rhFGF20) on cultured mouse vibrissal follicles; found rhFGF20 significantly induced growth of the follicles in vitro, stimulated proliferation of hair matrix cells, and activated Wnt signal pathway. PMID: 29713847
    2. This study confirmed that the A allele of rs591323 in FGF20 reduces the risk of developing sporadic PD (P = 0.013). Additionally, subjects with the AA + AG genotype have a reduced risk compared to individuals with the GG genotype (P = 0.024). PMID: 28238162
    3. the FGF20 gene might not play a dominating role in the genetic predisposition to essential tremor in Chinese Han population. PMID: 27040428
    4. Meta-analysis indicated that the rs12720208 polymorphism may be associated with the Parkinson's disease susceptibility in Caucasians PMID: 28191856
    5. This study suggested that there is no sufficient evidence to support the association between FGF20 rs12720208 polymorphism and Parkinson's disease risk. PMID: 27023076
    6. The results of this study indicated that rs12720208 may contribute to the risk of PD in Iranian population. PMID: 26070653
    7. Meta-analysis suggests that FGF20 rs1721100 C/G polymorphism is associated with sporadic sporadic Parkinson's diseases in Asians PMID: 25030126
    8. The meta-analysis showed an association between FGF20 gene rs1721100 polymorphism and risk of Parkinson's disease under a recessive model. PMID: 24942208
    9. The results showed no significant differences in the presence of rs1721100 or rs12720208 in the FGF20 gene between Parkinson's disease patients and controls. PMID: 23938014
    10. The results have not shown any effect of rs12720208 in the FGF20 gene on the risk of Parkinson's disease in patients residing in Russia PMID: 23516905
    11. This study revealed that the rs1721100(C/G) polymorphism is a risk factor for PD in Han Chinese population, while rs12720208(C/T) polymorphism is not significantly associated with Parkinson's disease. PMID: 22342445
    12. The data suggested that Fgf9/20 and Bmp7 organize the nephron progenitor niche and highlight the essential role of FGF20 in human kidney development. FGF signaling likely regulates multiple important steps in the stem cell niche. PMID: 22698282
    13. The common FGF20 rs12720208 SNP was not associated with the risk for Parkinson's disease (PD) in our population. In addition, we did not find nucleotide changes in miR-433 (that binds to the 3' UTR FGF20 mRNA) among our PD patients. PMID: 20471450
    14. The associations described, from mRNA expression to brain morphology to cognition and an interaction with aging, confirm a role of FGF20 in human brain structure and function during development and aging. PMID: 20427658
    15. Fibroblast growth factor 20 polymorphisms and haplotypes is associated with the risk of Parkinson disease PMID: 15122513
    16. Data show that FGF20 and DKK1 appear to be direct targets for beta-catenin/TCF transcriptional regulation via LEF/TCF-binding sites, and are expressed early in Xenopus embryogenesis under the control of the Wnt signaling pathway PMID: 15592430
    17. results suggest that the FGF20 gene is a susceptibility gene for Parkinson's disease in the Japanese population PMID: 17515805
    18. Variants in FGF20 and MAOB show evidence of statistical interactions and potential patterns of biological interaction contributing to Parkinson disease risk. PMID: 18205889
    19. Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. PMID: 18252210
    20. FGF20 is associated with Parkinson's disease synergistically with SNCA. PMID: 18568448
    21. Data demonstrate that homodimerization autoregulates FGF9 and FGF20's receptor binding and concentration gradients in the extracellular matrix. PMID: 19564416
    22. The effect of arginine on the solubility and stability of FGF-20 was dominated by the preferential binding interaction. PMID: 19619121
    23. FGF20, FGF9, and FGF16 constitute a subfamily among FGFs. FGF20 is preferentially expressed in colorectal cancer. PMID: 10913340

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  • 相关疾病：
    Renal hypodysplasia/aplasia 2 (RHDA2)
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 组织特异性：
    Predominantly expressed in the cerebellum.
  • 数据库链接：

    HGNC: 3677

    OMIM: 605558

    KEGG: hsa:26281

    STRING: 9606.ENSP00000180166

    UniGene: Hs.199905