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  4. Recombinant Human Follistatin (FST)

Recombinant Human Follistatin (FST)

  • 货号：
    CSB-YP009024HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009024HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009024HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009024HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009024HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Activin binding protein ; Activin-binding protein; Follistatin; FS; fst; FST_HUMAN; Human follistatin gene
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    30-344
  • 氨基酸序列
    G NCWLRQAKNG RCQVLYKTEL SKEECCSTGR LSTSWTEEDV NDNTLFKWMI FNGGAPNCIP CKETCENVDC GPGKKCRMNK KNKPRCVCAP DCSNITWKGP VCGLDGKTYR NECALLKARC KEQPELEVQY QGRCKKTCRD VFCPGSSTCV VDQTNNAYCV TCNRICPEPA SSEQYLCGND GVTYSSACHL RKATCLLGRS IGLAYEGKCI KAKSCEDIQC TGGKKCLWDF KVGRGRCSLC DELCPDSKSD EPVCASDNAT YASECAMKEA ACSSGVLLEV KHSGSCNSIS EDTEEEEEDE DQDYSFPISS ILEW
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).
  • 基因功能参考文献：
    1. these studies suggest that follistatin expression in invasive breast cancer is unrelated to the disease severity and the risk of recurrence, but is more intense in estrogen receptor -negative tumors PMID: 27389553
    2. Surface plasmon resonance analysis showed no significant association between FS288 and AMHC , suggesting that FS288 indirectly regulates AMH signaling. Activin A, a direct target of FS288, did not itself induce reporter activity in P19 cells, but did prevent the FS288-induced increase in AMH signaling. Hence, local concentrations of FS288 and Activin A may influence the response of some cell types to AMH. PMID: 28500669
    3. results suggest a role for FST as a suppressor of invasion and metastasis in breast cancer PMID: 28647698
    4. These data indicate that FST is a bona fide metastasis suppressor in this mouse model and support future efforts to develop an FST mimetic to suppress metastatic progression. PMID: 28583174
    5. These findings indicate that muscle-specific Fst overexpression in pigs enhances skeletal muscle growth, at least partly due to myofiber hypertrophy and providing a promising approach to increase muscle mass in pigs and other livestock. PMID: 27787698
    6. High follistatin expression is associated with lung adenocarcinoma. PMID: 26950277
    7. FST and KLK6 may have significance in breast cancer detection PMID: 27168011
    8. Follistatin and activin A are higher in MI than in CAD suggesting increased release due to myocardial necrosis. They can predict MI with accuracy similar to CK-MB PMID: 28732565
    9. The activin-A to follistatin ratio may play a role in determining the clinical phenotype of preterm birth as preterm labor or preterm premature rupture of membranes. PMID: 27159193
    10. Low follistatin expression is associated with liver cirrhosis. PMID: 27399349
    11. Follistatin levels are associated with circulating leptin levels and display a day-night rhythm and a menstrual cycle, but not a seasonal, variation. PMID: 27621181
    12. Within the nonalcoholic fatty liver disease group of patients, follistatin was associated with steatohepatitis independently from activin A PMID: 27621190
    13. annexin A2 but not follistatin is expressed in hepatocellular carcinoma PMID: 26189841
    14. FST plays a role in tumourigenesis, metastasis and angiogenesis of solid tumours through its interaction with activin and BMPs, thus resulting in pathophysiological function. In terms of diagnosis, prognosis and therapy, FST has shown strong promise PMID: 27807065
    15. Study shows that INHBA and FST are induced by seminal fluid in cervical tissues and thus, may contribute to regulation of the post-coital response in women. PMID: 26415587
    16. Circulating follistatin may be a marker of the glucagon-to-insulin tone on the liver PMID: 26652766
    17. serum concentrations positively associated with serum free thyroxine levels in hyperthyroid or euthyroid patients PMID: 26844494
    18. We report here an original observation that activin-B is upregulated in the human idiopathic pulmonary fibrosis lung. PMID: 25361680
    19. changes in Follistatin levels during pregnancy contribute to the control of the activin A system PMID: 25565002
    20. Two angiogenic factors, follistatin (and HGF) are associated with prognosis in esophageal cancer patients. PMID: 25885021
    21. Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors. PMID: 26086422
    22. an imbalance between activin-A and follistatin contributes to the pathogenesis of cigarette smoke-induced inflammation and COPD PMID: 24232707
    23. Circulating follistatin levels are reduced in gestational diabetes mellitus and are positively associated with fetal growth and neonatal adiposity. PMID: 24763182
    24. higher than normal serum values common in H1N1 infection but found no association with the severity of respiratory failure PMID: 24885241
    25. data strongly support that up-regulation of FST in chondrocytes by skeletal dysplasia-inducing TRPV4 mutations contributes to disease pathogenesis. PMID: 24577120
    26. Follistatin, by its ability to neutralize the actions of activin A may be of value as an antifibrotic for radiation induced fibrosis. PMID: 24204752
    27. Plasma follistatin is moderately elevated in patients with type 2 diabetes. PMID: 23564759
    28. It is considered to have a significant role during tumor progression by influencing angiogenesis and metastasis. Thus, it serum level is a good tumor marker for hepatocellular carcinoma. PMID: 23432377
    29. These results suggest that FOXL2 may act as a tumor suppressor in human adult-type GCTs by inducing follistatin expression, which subsequently inhibits activin-stimulated cell proliferation. PMID: 24332943
    30. study found that causative mutations in the coding region of the FST gene are rare in Chinese women with idiopathic premature ovarian failure PMID: 23113792
    31. In cultured endometrioma stromal cells, Il-1beta and TNF-alpha induced follistatin mRNA and protein. PMID: 23171678
    32. FOXL2 expression is required for GDF-9 stimulation of follistatin transcription. PMID: 23523567
    33. methylation levels of CpG sites in the FST promoter and 5'-UTR are not associated with polycystic ovary syndrome PMID: 23265961
    34. The intrinsic PK/PD properties of native FST315 are poorly suited for acting as a parentally administered biotherapeutic with broad systemic effects. PMID: 23249626
    35. Serum measurements of activin A, B, or follistatin cannot discriminate risk for type 2 diabetes in individual patients, but the activins display a positive relationship with clinical parameters of the disease. PMID: 23304117
    36. The present study demonstrated that serum follistatin is not significantly altered in peritoneal or deep infiltrating endometriosis and has limited diagnostic accuracy in the diagnosis of ovarian endometrioma. PMID: 22416010
    37. Binding of a specific ligand to FS288 differentially regulates its affinity and behavior for heparin molecules. PMID: 22809401
    38. FST is known to be an inhibitor of bone morphogenetic proteins (BMPs), which, coupled with the ability of TGF-beta2 to upregulate FST levels, may indicate a possible role of FST in the pathogenesis of glaucoma. PMID: 23010638
    39. The occurrence of the exonic variants of follistatin gene seems to be dependent on the ethnic background of the subjects under study and its role in the polycystic ovary syndrome pathophysiology cannot be established with hitherto available evidence. PMID: 23023351
    40. Findings suggest a function for breast cancer susceptibility gene 1 (BRCA1) as a regulator of follistatin (FST) expression and function in ovarian cells. PMID: 22685544
    41. Myostatin may have a role in abdominal obesity, androgen and follistatin levels in women with polycystic ovary syndrome PMID: 22693174
    42. After eccentric exercise, postmenopausal women not using hormone therapy (HT) expressed higher levels of follistatin while postmenopausal women using HT showed a significant increased expression over controls. PMID: 22395277
    43. Follistatin showed highly significant positive associations to the intrafollicular concentrations of antimullerian hormone and inhibin B. PMID: 21846490
    44. LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression. PMID: 21900845
    45. analysis of candidate genes revealed four genes that influence fertility: CGB/LHB gene cluster (p = 0.0036), FSHR (p = 0.023), FST (p = 0.023), and INHB; none of the independent SNPs in these genes predicted mortality PMID: 21222045
    46. increased follistatin levels occurred with inflammation, reduced muscle strength, and low bone mineral density, suggesting an involvement of a mechanism including follistatin in the uremic wasting process PMID: 21350111
    47. Disturbed expression of endometrial activin A, cripto , and follistatin suggests a dysfunction of the activin pathway in endometriosis/endometrioma. PMID: 21496809
    48. Effects of training and androgens on MYOPRO and FOLLI concentrations in blood and skeletal muscle, were investigated. PMID: 20801187
    49. Nucleolar follistatin promotes cancer cell survival under glucose-deprived conditions through inhibiting cellular rRNA synthesis. PMID: 20843798
    50. Changes in hepatically metabolised follistatin during and after exercise are reported. PMID: 21068158

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid. In the embryo, strong expression is seen in the palatal epithelia, including the medial edge epithelial and midline epithelial seam of the palatal shelves. Less pronoun
  • 数据库链接：

    HGNC: 3971

    OMIM: 136470

    KEGG: hsa:10468

    STRING: 9606.ENSP00000256759

    UniGene: Hs.9914