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  4. Recombinant Human Forkhead box protein C2 (FOXC2)

Recombinant Human Forkhead box protein C2 (FOXC2)

  • 中文名称：
    人FOXC2重组蛋白
  • 货号：
    CSB-YP857880HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FOXC2重组蛋白
  • 货号：
    CSB-EP857880HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FOXC2重组蛋白
  • 货号：
    CSB-EP857880HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FOXC2重组蛋白
  • 货号：
    CSB-BP857880HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FOXC2重组蛋白
  • 货号：
    CSB-MP857880HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXC2
  • Uniprot No.：
  • 别名：
    Drosphilia Forkhead Homolog Like 14; FKHL 14; FKHL14; Forkhead Box C2; Forkhead box protein C2; Forkhead related protein FKHL14; Forkhead-related protein FKHL14; FOX C2; Foxc2; FOXC2_HUMAN; LD; Mesenchyme fork head protein 1; Mesenchyme Forkhead 1; MFH 1; MFH 1 protein; MFH-1 protein; MFH1; Transcription factor FKH 14; Transcription factor FKH-14
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-501
  • 氨基酸序列
    MQARYSVSDP NALGVVPYLS EQNYYRAAGS YGGMASPMGV YSGHPEQYSA GMGRSYAPYH HHQPAAPKDL VKPPYSYIAL ITMAIQNAPE KKITLNGIYQ FIMDRFPFYR ENKQGWQNSI RHNLSLNECF VKVPRDDKKP GKGSYWTLDP DSYNMFENGS FLRRRRRFKK KDVSKEKEER AHLKEPPPAA SKGAPATPHL ADAPKEAEKK VVIKSEAASP ALPVITKVET LSPESALQGS PRSAASTPAG SPDGSLPEHH AAAPNGLPGF SVENIMTLRT SPPGGELSPG AGRAGLVVPP LALPYAAAPP AAYGQPCAQG LEAGAAGGYQ CSMRAMSLYT GAERPAHMCV PPALDEALSD HPSGPTSPLS ALNLAAGQEG ALAATGHHHQ HHGHHHPQAP PPPPAPQPQP TPQPGAAAAQ AASWYLNHSG DLNHLPGHTF AAQQQTFPNV REMFNSHRLG IENSTLGESQ VSGNASCQLP YRSTPPLYRH AAPYSYDCTK Y
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator. Might be involved in the formation of special mesenchymal tissues.
  • 基因功能参考文献：
    1. that FOXC2 could promote the invasion ability of normal trophoblast cells by epithelial-mesenchymal transition -mediated Hedgehog pathway PMID: 29465790
    2. REVIEW: current understanding of FOXC2 and provide potential mechanistic explanations of the relationship between FOXC2 and cancer, as well as discuss the prospect for future research in the promising prognostic value of FOXC2 in cancer PMID: 29341903
    3. The finding of rare LAMA5 variants together with FOXC2 mutations in lymphedema-distichiasis syndrome suggests that these mutations may be co-responsible for these disorders and most likely interfere with the function of lymphatics. PMID: 29908552
    4. In FOXC2 knockdown cell lines, CXCR4, a downstream target of FOXC2, can restore osteosarcoma cell invasiveness and metastasis to the lung PMID: 27634875
    5. Knockdown of FOXC2 inhibited HCC cell growth, migration, and invasion in vitro, as well as tumor growth. PMID: 29131008
    6. Studied interactions between protein kinase C alpha (PKCalpha), FOXC2, and p120-catenin (CTNND1) in breast cancer, cell migration/ invasion; found PKCalpha acts as an upstream regulator of FOXC2, which in turn represses the expression of p120-catenin, in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer. PMID: 29216867
    7. FOXC2 and CLIP4 activity correlates to the presence of
    8. either a complete loss or a significant gain of FOXC2 function can cause a perturbation of lymphatic vessel formation leading to lymphedema. PMID: 27276711
    9. Association of polymorphisms near the FOXC2 gene with the risk of varicose veins in ethnic Russians. PMID: 26420053
    10. respectively. Foxc2 is expressed in the developing kidney and therefore congenital renal anomalies may well be associated, potentially as a low penetrance feature. We propose that all individuals diagnosed with Lymphedema distichiasis syndrome should have a baseline renal ultrasound scan at diagnosis PMID: 28544699
    11. This is the first report of a FOXC2 mutation in hereditary distichiasis in the Chinese population. The findings expand the FOXC2 mutation spectrum and contribute to the understanding of the genotype-phenotype correlation of this disease. PMID: 27570485
    12. FOXC2 promoted the glycolysis in progression of nasopharyngeal carcinoma by activating YAP signaling PMID: 28433696
    13. s concluded that the lncRNA FOXC2-AS1 may promote doxorubicin resistance in OS by increasing the expression of transcription factor FOXC2, further facilitating ABCB1 expression. PMID: 28323030
    14. we demonstrate that FOXC2 is an important determinant of PCa stem-cell attributes, dictating the biochemical shift to ADT- and chemo-resistance PMID: 26804168
    15. our data demonstrate that FOXC2 regulates EMT, stem cell traits, ZEB1 expression and metastasis in a p38-dependent manner, and attest to the potential utility of p38 inhibitors as antimetastatic agents. PMID: 27292262
    16. Moreover, PLK1 activity is important for FOXC2 protein stability, since PLK1 inhibition reduces FOXC2 protein levels. PMID: 27064522
    17. Data suggest that forkhead box protein C2 (FOXC2) could be a potential therapeutic target for overcoming cisplatin (CDDP) resistance in ovarian cancer. PMID: 27336949
    18. High expression of FOXC2 is associated with pancreatic ductal adenocarcinoma. PMID: 26733175
    19. FOXC2 promotes epithelial-mesenchymal transition, migration and invasion in cisplatin-resistant human ovarian cancer cells. PMID: 27562816
    20. Evaluation of FoxC2 expression, alone or in combination with E-cadherin expression, may help to stratify non-small cell lung cancer patients for risk of disease progression, pointing to this EMT regulator as a potential prognostic marker PMID: 26758745
    21. Data indicate the role for altered forkhead box C2 (FoxC2)-Delta-like ligand 4 (Dll4)signaling in structural alterations of saphenous veins in patients with varicose veins. PMID: 26808710
    22. FOXC2 gene is associated with the glycolipid metabolic abnormality in T2DM patients. PMID: 27349002
    23. Adenovirus-mediated FoxC2 expression enhances BMP7-facilitated anabolism in nucleus pulposus cells of the intervertebral discs. PMID: 26824865
    24. The data indicate that the expression of FOXC2 in podocytes needs to be tightly regulated, and that its overexpression induces a chain of cellular events leading to podocyte dysfunction. PMID: 26524507
    25. Peri-tumoral lymphatics were associated with increased lymphatic metastasis. FOXC2 may be associated with the genesis of endometrial carcinoma and lymphangiogensis in endometrial adenocarcinoma in intra- and peri-tumoral lymphatics. PMID: 26125751
    26. our findings contribute to the putative targets in which the FLT4 gene mutation was found to have a significant role in lymphatic filariasis, while FOXC2 and FLT4 SNP interactions need to be further elucidated at a functional level. PMID: 26091406
    27. High FOXC2 expression is associated with tumor proliferation and invasion potential in oral tongue squamous cell carcinoma. PMID: 25573594
    28. In cultured lymphatic endothelial cells, FOXC2 inactivation conferred abnormal shear stress sensing, promoting junction disassembly and entry into the cell cycle. This was mediated by TAZ and led to cell death. PMID: 26389677
    29. we propose that Foxc2 is functionally maintained in the cytoplasm of normal epithelial cells by CK2alpha/alpha'-mediated phosphorylation at serine 124, which is dependent on proper targeting of the holoenzyme via the CK2b regulatory subunit. PMID: 25486430
    30. Twist and Foxc2 stromal expression in PTs was significantly correlated with tumour grade and worse histological features. PMID: 25677742
    31. The study defines the requirement of FOXC2 for phosphate-induced osteopontin (OPN) expression and secretion from cancer cells as necessary for the angiogenic response. PMID: 24700685
    32. FOXC2 expression was positively correlated with MET expression in CRC tissue samples. PMID: 25381815
    33. High expression of forkhead box protein C2 is related to gliomas. PMID: 25605149
    34. Results show that GD3S regulates stem cell function via c-Met and the expression of GD3S is regulated by FOXC2, a transcription factor functioning downstream of several epithelial-mesenchymal transition signaling pathways. PMID: 25109336
    35. targeting FOXC2 may provide a novel strategy for overcoming chemoresistance in nasopharyngeal carcinoma therapy. PMID: 25896630
    36. SENP3, which is increased in gastric cancer cells, potentiates the transcriptional activity of FOXC2 through de-SUMOylation, in favor of the induction of specific mesenchymal gene expression in gastric cancer metastasis. PMID: 25216525
    37. It was concluded that there is a significant association between FOXC2 and the metastasis of invasive breast cancer. PMID: 25480587
    38. we found a novel missense mutation of C.370C>T in a family with lymphoedema-distichiasis syndrome, which caused an amino acid change from leucine to phenylalanine (p.Leu124Phe). PMID: 24984567
    39. FOXC2 may promote the development of cervical cancer via regulation of angiogenesis. PMID: 25556265
    40. FOXC2 or its associated gene expression program may provide an effective target for anti-EMT-based therapies PMID: 24700112
    41. Results suggested that Prox1 and FOXC2 play key roles in OSCC progression and that further studies focusing on these proteins may yield useful insights for diagnosis and therapy of OSCC. PMID: 24647631
    42. FOXC2 gene expression increases with malignancy, especially with blood vessel hyperplasia and invasion degree. Targeted silencing was associated with reduced cell proliferation as well as invasion potential. PMID: 24641373
    43. Suggest that FOXC2 plays an essential role in colorectal cancer progression and may serve as a valuable clinical prognostic marker of this disease. PMID: 25069037
    44. Seven sporadic SEDAC subjects had no FOXC2 mutations, no symptoms of LDS, and showed differing clinical characteristics from those who had FOXC2 mutations, suggesting that other gene(s) besides FOXC2 are likely to be involved in SEDAC PMID: 24278289
    45. FOXC2 contributes to a poor prognosis and cancer progression in extrahepatic cholangiocarcinoma. PMID: 23919841
    46. FOXC2 is indispensable for all stages of lymphatic valve development [review] PMID: 24276887
    47. FoxC2 and p120ctn play important roles in the progression and prognosis of gastric cancer. PMID: 23614500
    48. Results indicate the pivotal role of phosphorylation in the regulation of FOXC2-mediated transcription in lymphatic endothelial cells. PMID: 23878394
    49. FOXC2 or its associated gene expression program may provide an effective target for anti-EMT-based therapies for the treatment of claudin-low/basal B breast tumors or other EMT-/CSC-enriched tumors PMID: 23378344
    50. de novo mutations and rare variants in hypoplastic left heart syndrome for FOXC2 gene PMID: 21457232

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  • 相关疾病：
    Lymphedema-distichiasis (LYD)
  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    HGNC: 3801

    OMIM: 153400

    KEGG: hsa:2303

    STRING: 9606.ENSP00000326371

    UniGene: Hs.436448