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  4. Recombinant Human Forkhead box protein E1 (FOXE1)

Recombinant Human Forkhead box protein E1 (FOXE1)

  • 货号：
    CSB-YP008811HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008811HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008811HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008811HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008811HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXE1
  • Uniprot No.：
  • 别名：
    FKH L15; FKHL 15; FKHL15; Forkhead (Drosophila) like 15; Forkhead box E1; Forkhead box E2; Forkhead box protein E1; Forkhead box protein E2; Forkhead drosophila homolog like 15; Forkhead like 15; Forkhead related protein FKHL 15; Forkhead related protein FKHL15; Forkhead-related protein FKHL15; FOX E1; FOX E2; FOXE 1; FOXE 2; FOXE1; FOXE1_HUMAN; FOXE2; HFKH 4; HFKH4; HFKL 5; HFKL5; HNF-3/fork head-like protein 5; Thyroid transcription factor 2; TITF 2; TITF2; TTF 2; TTF-2; TTF2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-373
  • 氨基酸序列
    MTAESGPPPP QPEVLATVKE ERGETAAGAG VPGEATGRGA GGRRRKRPLQ RGKPPYSYIA LIAMAIAHAP ERRLTLGGIY KFITERFPFY RDNPKKWQNS IRHNLTLNDC FLKIPREAGR PGKGNYWALD PNAEDMFESG SFLRRRKRFK RSDLSTYPAY MHDAAAAAAA AAAAAAAAAI FPGAVPAARP PYPGAVYAGY APPSLAAPPP VYYPAASPGP CRVFGLVPER PLSPELGPAP SGPGGSCAFA SAGAPATTTG YQPAGCTGAR PANPSAYAAA YAGPDGAYPQ GAGSAIFAAA GRLAGPASPP AGGSSGGVET TVDFYGRTSP GQFGALGACY NPGGQLGGAS AGAYHARHAA AYPGGIDRFV SAM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
  • 基因功能参考文献：
    1. We confirmed the association of FOXE1 gene and cleft lip with or without cleft palate by a family based study. For the first time, rs1867277 was significantly associated with cleft lip with or without cleft palate PMID: 29509083
    2. Mutations of TTF2 is associated with risk of Papillary Thyroid Cancer in Chinese. Patients with Multiplendular goiter and no metastasis are more likely to suffer PTC. G/A mutation of TTF2 had a high correlation with PTC in the overall population. PMID: 26356687
    3. Report that PTCSC2 binds myosin-9 (MYH9). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 inhibits the promoter activity in both directions. This inhibition can be reversed by PTCSC2, which acts as a suppressor. PMID: 28049826
    4. replication confirmed at genome-wide significance the association of loci at FOXE1 with hypothyroidism, and PDE8B, CAPZB and PDE10A with serum TSH. A total of 12 SNPs seemed to explain nearly 7% of the serum TSH variation PMID: 28727628
    5. The functional variants rs965513 and rs1867277 independently contribute to genetic predisposition to papillary thyroid carcinoma, while a contributing role of the FOXE1 poly-Ala polymorphism could not be confirmed. PMID: 27824288
    6. FOXE1 interacts with ELK1 on thyroid relevant gene promoters, establishing a new regulatory pathway for its role in adult thyroid function. Co-regulation of TERT suggests a mechanism by which allelic variants in/near FOXE1 are associated with thyroid cancer risk. PMID: 27852061
    7. In a Cuban population, differentiated thyroid cancer risk was positively and strongly associated with the number of copies in the minor allele (A) for SNP rs965513 near FOXE1 among people who consumed less iodine than the median. PMID: 27610545
    8. methylation-mediated silencing of FOXE1 expression may contribute to the progression of CRC. PMID: 27271927
    9. The rs965513 polymorphism is a risk factor for thyroid cancer.[meta-analysis] PMID: 27191655
    10. Patient-related factors modify the predisposition to papillary thyroid carcinoma by increasing the risk for rs944289 (near the NKX2-1 locus) per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men. PMID: 28660995
    11. We identified a FOXE1: c.532_537delGCCGCC p.(Ala178_Ala179del) variant that predisposes to thyroid ectopia. Taken together, this is the first report of mosaic 11p13 deletion in association with thyroid dysgenesis PMID: 28398607
    12. Our results implicate FOXE1 as an important locus whose polymorphic variation increases risks for all types of isolated clefts, and opens a new biological pathway to investigate in efforts to understand genetic factors underlying human clefting. PMID: 27604706
    13. FOXE1 polyalanine repeat polymorphisms are associated with thyroid cancer, but only for tumours larger than 1 cm, suggesting a role in disease progression. PMID: 27474100
    14. In the analysis of all OFCs combined, SNPs near FOXE1 reached genome-wide significance PMID: 28054174
    15. FOXE1 was the only gene which was over-expressed in six out of eight lung cancer cell lines and human cancer tissue specimens and is an important regulator by targeting autophagy and Matrix Metalloproteinases pathways in lung cancer development. PMID: 27755953
    16. Taken together, this study showed that rs7043516 may be considered as a potentially susceptible marker of cleft lip only among Chinese Han populations. PMID: 26728781
    17. this study shows that FOXE1 polymorphism is strongly associated with non-syndromic cleft lip and palate in populations in northeast China PMID: 26100861
    18. High Levels of mRNA of both FOXE1 are associated with benign than in malignant thyroid lesions. PMID: 26370671
    19. Our findings suggest that FOXE1 variations generate a higher risk for poor histopathological features of papillary thyroid carcinoma PMID: 26722557
    20. genetic susceptibility to thyroid cancer seems likely to be associated with the risk alleles at rs1867277, rs965513, rs1443434, and rs907580 PMID: 26206751
    21. analysis of novel somatic mutations of FOXE1 in papillary thyroid cancer PMID: 25950909
    22. Causal mutations for orofacial clefting and thyroid diseases occur within cis-regulatory elements at the human FOXE1 locus. PMID: 25652407
    23. In pancreatic cancer cells, AF6 is expressed at reduced levels, causing Dvl2 to be upregulated and available to bind and enhance FOXE1-induced trans-activation of Snail, which promotes proliferation and metastasis. PMID: 26013125
    24. FOXE1 germline rare variant is involved in familal non-medullary thyroid carcinoma. PMID: 25381600
    25. our data suggest that SYNE1 and FOXE1 are promising markers for colorectal cancer detection. PMID: 25538088
    26. Our data suggest a role for PTCSC2, FOXE1, and TSHR in the predisposition to papillary thyroid carcinoma. PMID: 25303483
    27. Findings suggest that the SNPs in XKR4 and near FOXE1 are involved in the regulation of TSH levels. PMID: 24852370
    28. study identifies probable susceptibility variants of FOXE1 for oral clefts in the Thai population PMID: 24252547
    29. genetic association studies in population in Germany: Data suggest that an SNP in FOXE1 (rs965513) is associated with increased risk for differentiated thyroid cancer (of an aggressive nature) in the population studied. PMID: 24325646
    30. FOXE1 and SYNE1 hypermethylation markers demonstrated significantly increased expression in neoplastic tissue. PMID: 24280874
    31. Common variations of FOXE1 are a risk factor associated with increased thyroid cancer susceptibility. PMID: 24489898
    32. The current meta-analysis provided evidence that FOXE1 genetic polymorphisms may contribute to increased papillary thyroid carcinoma risk..ATM genetic polymorphisms may not be important dominants of susceptibility to this neoplasm. PMID: 24756757
    33. three common variations on FOXE1 is a risk factor associated with increased thyroid cancer susceptibility, but these associations vary in different ethnic populations PMID: 24744143
    34. A tissue-dependent differentially methylated regions (DMR) in the FOXE1 promoter. This DMR contains two consecutive CpG dinucleotides, which are epigenetic modifiers of FOXE1 expression in nontumoral tissues. PMID: 24646064
    35. These results strongly support the FOXE1 locus as a risk factor for nsOFC. With the data of the initial study, there is now considerable evidence that this locus is the first conclusive risk factor shared between nsCL/P and nsCPO. PMID: 24563486
    36. Significant association with PTC was found for rs1801516 (D1853N) in ATM and rs1867277 in the promoter region of FOXE1 (OR = 1.55, 95% CI 1.03, 2.34). PMID: 24105688
    37. single nucleotide polymorphisms at 9q22.33 near FOXE1 showed convincing evidence of association with nonmedullary thyroid carcinoma risk in high-risk families PMID: 24127282
    38. Nuclear FOXE1 expression in tumor cells in vicinity of the PTC border is associated with presence of a risk allele of rs1867277 (c.-238G>A) in the 5' untranslated region of the FOXE1 gene, as well as with pathological characteristics of PTC. PMID: 23327367
    39. the FOXE1 gene exhibits significant differential expression levels between PTC tissues and adjacent non-tumor thyroid tissues. PMID: 23715628
    40. In addition, eight genes classified as 'second tier' hits in the original study (PAX7, THADA, COL8A1/FILIP1L, DCAF4L2, GADD45G, NTN1, RBFOX3 and FOXE1) showed evidence of linkage and association in this replication sample. PMID: 23512105
    41. study showed evidence of association between forkhead box E1 (FOXE1) variants and thyroid cancer risk in the Portuguese population PMID: 22882326
    42. coding polyalanine expansion in FOXE1 may be responsible for the observed association between FOXE1 and papillary thyroid cancer PMID: 22736773
    43. FOXE1 genes suggest a role for orofacial clefting in hispanic polulation. PMID: 22753311
    44. Novel associations for hypothyroidism and autoimmune risk loci include SNPs near the FOXE1 gene. PMID: 22493691
    45. Polyalanine repeat expansions in FOXE1 is associated with the genetic aetiology of POF in Chinese women. PMID: 22177572
    46. Both FOXE1 and NKX2-1 were associated with the increased risk of sporadic Japanese PTC. PMID: 21730105
    47. these results excluded the association of poly (Ala) polymorphism with autoimmune thyroid diseases; however it confirms the involvement of FOXE1 in the genesis of thyroid carcinoma. PMID: 21896990
    48. FOXE1-polyAla tract expansion may contribute to the molecular background of familial but not sporadic forms of thyroid hemiagenesis. PMID: 21311165
    49. Polymorphisms in TIMP2 and WNT9B are novel loci predisposing to cleft palate. PMID: 21462296
    50. Effects of genetic variation in FOXE1 on serum free thyroxine (FT4) levels in Caucasian populations are demonstrated, as well as borderline significant effects on serum thyroid hormone (TSH) levels. PMID: 21367965

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  • 相关疾病：
    Bamforth-Lazarus syndrome (BLS); Thyroid cancer, non-medullary, 4 (NMTC4)
  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.
  • 数据库链接：

    HGNC: 3806

    OMIM: 241850

    KEGG: hsa:2304

    STRING: 9606.ENSP00000364265

    UniGene: Hs.159234