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  4. Recombinant Human Forkhead box protein F2 (FOXF2)

Recombinant Human Forkhead box protein F2 (FOXF2)

  • 货号：
    CSB-YP623661HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP623661HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP623661HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP623661HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP623661HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXF2
  • Uniprot No.：
  • 别名：
    FOXF2; FKHL6; FREAC2Forkhead box protein F2; Forkhead-related activator 2; FREAC-2; Forkhead-related protein FKHL6; Forkhead-related transcription factor 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-444
  • 氨基酸序列
    MTTEGGPPPA PLRRACSPVP GALQAALMSP PPAAAAAAAA APETTSSSSS SSSASCASSS SSSNSASAPS AACKSAGGGG AGAGSGGAKK ASSGLRRPEK PPYSYIALIV MAIQSSPSKR LTLSEIYQFL QARFPFFRGA YQGWKNSVRH NLSLNECFIK LPKGLGRPGK GHYWTIDPAS EFMFEEGSFR RRPRGFRRKC QALKPMYHRV VSGLGFGASL LPQGFDFQAP PSAPLGCHSQ GGYGGLDMMP AGYDAGAGAP SHAHPHHHHH HHVPHMSPNP GSTYMASCPV PAGPGGVGAA GGGGGGDYGP DSSSSPVPSS PAMASAIECH SPYTSPAAHW SSPGASPYLK QPPALTPSSN PAASAGLHSS MSSYSLEQSY LHQNAREDLS VGLPRYQHHS TPVCDRKDFV LNFNGISSFH PSASGSYYHH HHQSVCQDIK PCVM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Probable transcription activator for a number of lung-specific genes. Mediates up-regulation of the E3 ligase IRF2BPL and drives ubiquitination and degradation of CTNNB1.
  • 基因功能参考文献：
    1. FOXF2 rs1711972 AA genotype is associated with poor response to therapy in Non-small Cell Lung Cancer. PMID: 28766235
    2. miR130a can regulate FOXF2 and function as an oncogene in colorectal cancer. PMID: 28849155
    3. FOXF2 deficiency induced mesenchymal-epithelial transition (MET) in Huh7 cell which might facilitate the colonization of circulating tumor cells and the formation of metastasis. PMID: 28582850
    4. Cox proportional hazards regression model was used to evaluate the predictive value of FOXF2 mRNA level in non-small cell lung cancer patients PMID: 27487137
    5. FOXF2 has a dual role in breast tumorigenesis and functions as either a tumor suppressor or an oncogene depending on the breast tumor subtype. PMID: 27377963
    6. MAZ/FOXF2 axis can promote the proliferation of basal like breast cancer cells and suppress disease progression. PMID: 28577976
    7. direct targeting of Foxf2 by Shh signaling drives cranial neural crest cell mesenchyme proliferation during upper lip morphogenesis, and disruption of this sequence results in cleft lip. PMID: 28506991
    8. Common variants near FOXF2 that are associated with increased stroke susceptibility. PMID: 27068588
    9. No correlation was found between FOXF2 promoter methylation and other clinic pathological parameters (age, gender, differentiation, lymph node metastasis, stage, cutting edge, vascular invasion, smoking behavior, and drinking history) in esophageal squamous cell carcinoma. PMID: 28222662
    10. Loss of FOXF2 Expression is associated with Hepatocellular Carcinoma. PMID: 25824262
    11. results provided statistical evidence of linkage and association between FOXF2 and nonsyndromic cleft lip with or without cleft palate. PMID: 26278207
    12. The miR-200 family and the miR-183~96~182 cluster target Foxf2 to inhibit invasion and metastasis in lung cancers. PMID: 25798833
    13. MiR-182-induced downregulation of FoxF2. PMID: 25738520
    14. Subtype-specific expression and function of FOXF2 in breast cancer cells are regulated through the combined effects of DNA methylation and SP1 transcriptional regulation. PMID: 26070560
    15. Foxf2 inactivation in adults resulted in blood-brain barrier breakdown, endothelial thickening, and increased trans-endothelial vesicular transport PMID: 26120030
    16. decreased FOXF2 expression indicates the early-onset metastasis and poor prognosis for patients with histological grade II and triple-negative breast cancer. PMID: 23620774
    17. MicroRNA-182-5p promotes cell invasion and proliferation by down regulating FOXF2, RECK and MTSS1 genes in human prostate cancer. PMID: 23383207
    18. 2 unique DNA sequence alterations could have affected FOXF2 on the mRNA or protein level thus contributing to the observed disturbances in genital and palate development PMID: 19276632
    19. The distinct expression pattern of FOXF2 in the prostate, its effect on expression of signaling, and its opposing role in the TGFbeta3 pathway, suggests a role for FOXF2 in prostate homeostasis and stroma-epithelial interactions PMID: 19562724

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Lung and placenta. Predominantly expressed in gastrointestinal tract including stomach.
  • 数据库链接：

    HGNC: 3810

    OMIM: 603250

    KEGG: hsa:2295

    STRING: 9606.ENSP00000259806

    UniGene: Hs.484423