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  4. Recombinant Human Forkhead box protein Q1 (FOXQ1)

Recombinant Human Forkhead box protein Q1 (FOXQ1)

  • 中文名称：
    人FOXQ1重组蛋白
  • 货号：
    CSB-YP874860HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人FOXQ1重组蛋白
  • 货号：
    CSB-EP874860HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人FOXQ1重组蛋白
  • 货号：
    CSB-EP874860HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人FOXQ1重组蛋白
  • 货号：
    CSB-BP874860HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人FOXQ1重组蛋白
  • 货号：
    CSB-MP874860HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    FOXQ1
  • Uniprot No.：
  • 别名：
    Forkhead box protein Q1; Forkhead box Q1; FOX Q1; FOXQ 1; FOXQ1; FOXQ1_HUMAN; Hepatocyte nuclear factor 3 forkhead; Hepatocyte nuclear factor 3 forkhead homolog 1; HFH 1; HFH-1; HFH1; HNF 3/forkhead like protein 1; HNF-3/forkhead-like protein 1; HNF3/forkhead like protein 1; MGC77469; Q1; Winged helix / forkhead transcription factor; Winged helix/forkhead transcription factor; zgc:77469
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-403
  • 氨基酸序列
    MKLEVFVPRA AHGDKQGSDL EGAGGSDAPS PLSAAGDDSL GSDGDCAANS PAAGGGARDT QGDGEQSAGG GPGAEEAIPA AAAAAVVAEG AEAGAAGPGA GGAGSGEGAR SKPYTRRPKP PYSYIALIAM AIRDSAGGRL TLAEINEYLM GKFPFFRGSY TGWRNSVRHN LSLNDCFVKV LRDPSRPWGK DNYWMLNPNS EYTFADGVFR RRRKRLSHRA PVPAPGLRPE EAPGLPAAPP PAPAAPASPR MRSPARQEER ASPAGKFSSS FAIDSILRKP FRSRRLRDTA PGTTLQWGAA PCPPLPAFPA LLPAAPCRAL LPLCAYGAGE PARLGAREAE VPPTAPPLLL APLPAAAPAK PLRGPAAGGA HLYCPLRLPA ALQAASVRRP GPHLPYPVET LLA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in hair follicle differentiation.
  • 基因功能参考文献：
    1. inhibition of FOXQ1 restricted natural killer/T-cell lymphoma cell proliferation and growth but induced apoptosis PMID: 29132010
    2. Findings indicate a positive feedback loop between cancer associated fibroblast (CAFs) and box Q1 (FOXQ1)/N-myc downstream-regulated gene 1 (NDRG1) axis in neoplastic cells to drive hepatocellular carcinoma (HCC) initiation, suggesting new potential therapeutic targets for HCC. PMID: 29248714
    3. Results show that FOXQ1, a well-known oncogenic protein and promoter of gastric cancer (GC) metastasis, to be the direct downstream target of miR-345 in GC. Its mRNA and protein levels are up-regulated in GC tumors. PMID: 29048674
    4. These data identify FOXQ1 as a melanoma suppressor. PMID: 28930679
    5. Results revealed that, co-culture with TAMs promoted the invasion and migration of GC cells. Co-culture with TAMs induced EMT in GC cells. FOXQ1 is essential for TAM-induced EMT and metastasis in GC cells. PMID: 28791370
    6. FOXQ1 remarkably inhibited the replicative senescence through depressing the expression of the inflammatory cytokines interleukin-6 (IL-6) and IL-8 via modulation of SIRT1-NF-kappaB pathway. PMID: 28726780
    7. Cell viability and progression from G1 to S phase were both improved with overexpression of Foxq1, and microRNAs profiling study and dual-luciferase result suggested miR-320b contributed to the up-regulation of Foxq1 after calcium hydroxide stimulation. These results suggested that miR-320b mediated Foxq1 up-regulation promote proliferation of dental pulp stem cells. PMID: 29453987
    8. We identified FOXM1 and FOXQ1 as novel prognostic biomarkers in colorectal cancer and miR-342 as a novel regulator of both FOXM1 and FOXQ1 PMID: 27162244
    9. Data indicate a role for the miR-320/SOX4/FOXM1/FOXQ1 axes in promoting colorectal cancer (CRC) development and suggest targeting those networks as potential therapeutic strategy for CRC. PMID: 27119506
    10. MiR-133 directly targeted and down-regulated FOXQ1 expression, which in turn reduced TGF-beta level. PMID: 26858166
    11. There are several modes of regulation of FOXQ1 expression that have been demonstrated in normal and tumor cells, such as microRNA and the Wnt signaling pathway. The activation of FOXQ1 affects downstream genes promoting the initiation, proliferation and invasion, in addition to the metastasis of tumor cells PMID: 27176124
    12. FOXQ1 is a prognostic marker for patients with Gastric cancer, FOXQ1 over-expression is involved in acquisition of the mesenchymal phenotype of gastric cancer cells, and subsequent Snail expression is essential for induction of Epithelial-Mesenchymal Transition. PMID: 27109028
    13. The miR-506/FOXQ1 axis plays an important role in the pathogenesis of cervical cancer. PMID: 26935526
    14. DATS administration inhibited ALDH1 activity in vivo in SUM159 xenografts. These results indicate that FoxQ1 is a novel target of bCSC inhibition by DATS. PMID: 27129776
    15. Data suggest that forkhead box Q1 (FOXQ1) is a potential therapeutic target for the development of therapies for colorectal cancer. PMID: 25955104
    16. we identified FOXQ1 as an oncogene to promote ESCC tumor cell proliferation and metastasis by negatively regulating CDH1 in esophageal squamous cell carcinoma cells PMID: 26349968
    17. MiR-1271 inhibits cell proliferation, invasion, and epithelial-mesenchymal transition in gastric cancer by directly suppressing FOXQ1 expression. PMID: 26159618
    18. Results demonstrate that miR-124 functions as a tumor-suppressive microRNA in nasopharyngeal carcinoma by repressing Foxq1 expression. PMID: 25098939
    19. FoxQ1 expression is negatively associated with the overall survival of PC patients, and that this protein may therefore represent a novel molecular target and new prognostic biomarker for PC. PMID: 26122655
    20. miR-506 functions as a tumor suppressor miRNA in nasopharyngeal carcinoma; its suppressive effects are mediated chiefly by repressing FOXQ1 expression. PMID: 25856555
    21. NSCLC cells with silenced FoxQ1 had decreased cell proliferation, migration and invasion in cell culture and delayed growth of xenograft tumors in mice compared with corresponding control cells. PMID: 25356753
    22. PDGFRalpha and beta can be directly regulated by Foxq1 or indirectly regulated through the Foxq1/Twist1 axis PMID: 25502837
    23. The induction of EMT by FOXQ1 defines a new transfer function in promoting cancer behind possible mechanisms. PMID: 25287361
    24. FOXQ1 expression is essential to maintain cell proliferation, motility/invasion, and epithelial-mesenchymal transition phenotypes in ovarian cancer cells. PMID: 23203039
    25. critical role in the regulation of hepatocellular carcinoma development PMID: 25251503
    26. Data indicate that knockdown of forkhead box Q1 protein FoxQ1 by its siRNA in cancer stem-like cells (CSLCs) resulted in the inhibition of aggressive behavior. PMID: 24719318
    27. NAC1 is essential and sufficient for activation of FOXQ1 PMID: 24200849
    28. FoxQ1 promotes hepatocellular carcinoma metastasis by transactivating ZEB2 and VersicanV1 expression. PMID: 24005989
    29. High FoxQ1 expression is associated with hepatocarcinoma. PMID: 24211718
    30. results show that FOXQ1 is a novel modulator of Twist1 expression and a regulator of colorectal cancer invasion and metastasis PMID: 23723077
    31. Study demonstrates that an aggressive malignant phenotype of hepatocellular carcinoma is strongly linked to high FOXQ1 expression. PMID: 23623360
    32. FOXQ1 expression level is an independent prognostic factor for the overall survival rate of gastric cancer patients. PMID: 23609035
    33. Data show that FOXQ1 is one of the most over-expressed genes in CRC and a direct target of the canonical Wnt pathway. PMID: 23555880
    34. FOXQ1 may be a novel epithelial-mesenchymal transition-inducing transcription factor through controlling the expression of E-cadherin. PMID: 23403865
    35. FoxQ1 promotes glioma cell proliferation and migration by down-regulation of NRXN3 expression. PMID: 23383267
    36. Increased levels of this transcription factor suggest a potential link with cell dysfunction induced by altered prelamin A metabolism. PMID: 22948034
    37. this study showed that an interaction between FOXQ1 and SUMO1P1 for psychomotor speed. PMID: 22126837
    38. Mechanistic investigations revealed that FOXQ1-induced EMT was associated with transcriptional inactivation of the epithelial regulator E-cadherin. Findings define a key role for FOXQ1 in regulating EMT and aggressiveness in human cancer. PMID: 21346143
    39. Foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis. PMID: 21285253
    40. FOXQ1 overexpression upregulated several genes that have positive roles for tumor growth of colorectal cancer. PMID: 20145154
    41. Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via this protein PMID: 12011061
    42. This study demenostrated that the forkhead transcription factor is reduced in skeletal muscle of chronic spinal cord-injured patients. PMID: 19533653

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed predominantly in the stomach, trachea, bladder and salivary gland.
  • 数据库链接：

    HGNC: 20951

    OMIM: 612788

    KEGG: hsa:94234

    STRING: 9606.ENSP00000296839

    UniGene: Hs.591352