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  4. Recombinant Human GTPase IMAP family member 5 (GIMAP5), partial

Recombinant Human GTPase IMAP family member 5 (GIMAP5), partial

  • 中文名称：
    人GIMAP5重组蛋白
  • 货号：
    CSB-YP853414HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GIMAP5重组蛋白
  • 货号：
    CSB-EP853414HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GIMAP5重组蛋白
  • 货号：
    CSB-EP853414HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GIMAP5重组蛋白
  • 货号：
    CSB-BP853414HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GIMAP5重组蛋白
  • 货号：
    CSB-MP853414HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GIMAP5
  • Uniprot No.：
  • 别名：
    FLJ11296; GIMA5_HUMAN; GIMAP 5; GIMAP5; GTPase IMAP family member 5; hIAN5; HIMAP3; IAN 5 ; IAN4; IAN4L1; IAN5; IMAP3; Immune associated nucleotide 4 like 1; Immunity associated nucleotide 4 like 1 protein; Immunity associated protein 3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes. Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation. Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function. May promote the survival of mature T lymphocytes upon cytokine withdrawal. May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation. May play a role in mitochondrial DNA segregation in hematopoietic tissues.
  • 基因功能参考文献：
    1. GIMAP5 loss-of-function mutation results in T cell deficiencies. PMID: 29382851
    2. These data,demonstrating the downregulation of the mRNA and protein expression levels of GIMAP5 and GIMAP6 in the tumor tissues and blood of patients with HCC, suggested the involvement of GIMAP5 and GIMAP6 in the pathogenesis of HCC, and indicate their possible use as diagnostic markers for HCC. PMID: 27667392
    3. gimap5 has a role in maintaining peripheral tolerance and T cell homeostasis in the gut [review] PMID: 25944983
    4. Data indicate that overexpression of GTPase of the immune-associated nucleotide-binding protein 5 (GIMAP5) in HEK (human embryonic kidney)-293 cells resulted in increased Ca2+ accumulation within the mitochondria. PMID: 23098229
    5. Notch signalling protects T-ALL cells from apoptosis by upregulating the expression of GIMAP5. PMID: 20817506
    6. These data establish Gimap5 as a key regulator of hematopoietic integrity and lymphocyte homeostasis PMID: 20190135
    7. A significant increase in systemic lupus erythematosus risk associated with the most common GIMAP5 haplotype was found (odds ratio 1.26, 95% CI 1.02 to 1.54, p = 0.0033). PMID: 17220214
    8. Resutls show that Gimap5 is located in the endoplasmic reticulum, and the endogenous Gimap5 mRNA is up-regulated in activated T-cells. PMID: 17369194
    9. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same single nucleotide polymorphism in another autoimmune disease. PMID: 17641683
    10. Data show that IAN5 polymorphisms are associated with susceptibility to Systemic lupus erythematosus and the development of clinical disease manifestations in a strictly Korean population. PMID: 19762377

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  • 亚细胞定位：
    Lysosome membrane; Single-pass type IV membrane protein. Endosome, multivesicular body membrane; Single-pass type IV membrane protein. Endosome membrane; Single-pass type IV membrane protein.
  • 蛋白家族：
    TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily
  • 组织特异性：
    Widely expressed with high levels in lymph node and spleen. High expression found in T lymphocytes, including CD4 and CD8-positive T-cells, and monocytes. Very low expression levels in B-lymphocytes.
  • 数据库链接：

    HGNC: 18005

    OMIM: 608086

    KEGG: hsa:55340

    STRING: 9606.ENSP00000351473

    UniGene: Hs.647079