Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Human GTPase SLIP-GC (C8orf80)

Recombinant Human GTPase SLIP-GC (C8orf80)

  • 货号：
    CSB-YP718072HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP718072HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP718072HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP718072HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP718072HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NUGGC
  • Uniprot No.：
  • 别名：
    NUGGC; C8orf80; HMFN0672; Nuclear GTPase SLIP-GC; EC 3.6.1.-; Speckled-like pattern in the germinal center
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-796
  • 氨基酸序列
    MAETKDVFGQ EPHPVEDDLY KERTRKRRKS DRDQRFRAFP SMEQSALKEY EKLESRTRRV LSNTYQKLIQ SVFLDDSIPN GVKYLINRLL ALIEKPTVDP IYIALFGSTG AGKSSLINAI IQQAMFLPVS GESICTSCIV QVSSGCCVQY EAKIHLLSDQ EWREELKNLT KLLHRTEELS REEADAWNRD EAVEEATWKL QMIYGNGAES KNYEELLRAK PKRKIPTSRV ITLKAEEAEE LSIKLDPYIR TQRRDWDGEA AEMRIWPLIK HVEVTLPKSD LIPEGVVLVD IPGTGDFNSK RDEMWKKTID KCSVIWVISD IERVSGGQAH EDLLNESIKA CQRGFCRDVA LVVTKMDKLH LPEYLRERKA GNQAIQSQRE AVLERNEMIK LQRTRILKEK LKRKLPADFK VLEASDLVYT VSAQEYWQQA LLTEEETEIP KLREYIRKSL LDKKKRTVTK YVTEAFGLLL LTDSFNSTQN LPNEHLHMSV LRRFAEEKVE LLEKAIAQCF ACMEQPLQEG VRTARTSYRC ILRACLVRSK GNQGFHQTLK AVCLKNGIYA SRTLARIDLN EALTQPVYDQ IDPVFGSIFR TGKPTGSALM PHIDAFKQSL QEKMTEIGIR SGWKYDSCKK NFLIQEISAI LGGLEDHILR RKRRIYESLT ASVQSDLKLC YEEAAQITGK KACERMKDAI RRGVDRQVAE GMFERAQERM QHQFQQLKTG IVEKVKGSIT TMLALASSQG DGLYKELADV GSEYKEMEKL HRSLREVAEN ARLRKGMQEF LLRASPSKAG PPGTSL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nuclear GTPase found in germinal center B-cells, where it may inhibit function of the activation-induced cytidine deaminase AICDA. Reduces somatic hypermutation in B-cells which may enhance genome stability.
  • 基因功能参考文献：
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    2. SLIP-GC is a replication-related protein in germinal center B cells whose reduction is toxic to cells through an AICDA-dependent mechanism. PMID: 19734146
  • 亚细胞定位：
    Nucleus speckle.
  • 组织特异性：
    Expressed in germinal center B-cell and in lymphomas derived from germinal center B-cell.
  • 数据库链接：

    HGNC: 33550

    KEGG: hsa:389643

    UniGene: Hs.370129