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  4. Recombinant Human Gametogenetin-binding protein 2 (GGNBP2)

Recombinant Human Gametogenetin-binding protein 2 (GGNBP2)

  • 中文名称：
    人GGNBP2重组蛋白
  • 货号：
    CSB-YP863969HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GGNBP2重组蛋白
  • 货号：
    CSB-EP863969HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GGNBP2重组蛋白
  • 货号：
    CSB-EP863969HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GGNBP2重组蛋白
  • 货号：
    CSB-BP863969HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GGNBP2重组蛋白
  • 货号：
    CSB-MP863969HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GGNBP2
  • Uniprot No.：
  • 别名：
    DIF-3; DIF3; FLJ21230; FLJ22561; Gametogenetin-binding protein 2; GGNB2_HUMAN; Ggnbp2; Laryngeal carcinoma-related protein 1; LCRG1; LZK1; Protein ZNF403; ZFP403; ZNF403
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-697
  • 氨基酸序列
    MARLVAVCRD GEEEFPFERR QIPLYIDDTL TMVMEFPDNV LNLDGHQNNG AQLKQFIQRH GMLKQQDLSI AMVVTSREVL SALSQLVPCV GCRRSVERLF SQLVESGNPA LEPLTVGPKG VLSVTRSCMT DAKKLYTLFY VHGSKLNDMI DAIPKSKKNK RCQLHSLDTH KPKPLGGCWM DVWELMSQEC RDEVVLIDSS CLLETLETYL RKHRFCTDCK NKVLRAYNIL IGELDCSKEK GYCAALYEGL RCCPHERHIH VCCETDFIAH LLGRAEPEFA GGRRERHAKT IDIAQEEVLT CLGIHLYERL HRIWQKLRAE EQTWQMLFYL GVDALRKSFE MTVEKVQGIS RLEQLCEEFS EEERVRELKQ EKKRQKRKNR RKNKCVCDIP TPLQTADEKE VSQEKETDFI ENSSCKACGS TEDGNTCVEV IVTNENTSCT CPSSGNLLGS PKIKKGLSPH CNGSDCGYSS SMEGSETGSR EGSDVACTEG ICNHDEHGDD SCVHHCEDKE DDGDSCVECW ANSEENDTKG KNKKKKKKSK ILKCDEHIQK LGSCITDPGN RETSGNTMHT VFHRDKTKDT HPESCCSSEK GGQPLPWFEH RKNVPQFAEP TETLFGPDSG KGAKSLVELL DESECTSDEE IFISQDEIQS FMANNQSFYS NREQYRQHLK EKFNKYCRLN DHKRPICSGW LTTAGAN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May be involved in spermatogenesis.
  • 基因功能参考文献：
    1. Results identified GGNBP2 as a novel tumor suppressor which is downregulated in human breast tumors and cell lines and suggest that GGNBP2 may function as a corepressor to inhibit ERa's transcriptional activity and consequently inhibit tumorigenic potential of breast cancer cells. PMID: 27357812
    2. The effects of ZFP403 on cell proliferation and metastasis suggest that it may serve as a tumor suppressor in ovarian cancer. PMID: 28864131
    3. Results show that downregulation of RNASET2 and GGNBP2 in drug-resistant ovarian cancer tissues/cells contributes to the regulation of drug resistance in ovarian cancer. PMID: 24842157
    4. There is an essential role for ZNF403 in cell proliferation and G2/M cell-cycle transition. PMID: 22350815
    5. LCRG1 is a novel gene localized to the tumor suppressor locus D17S800-D17S930 involved in laryngeal carcinoma. PMID: 15145523

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  • 亚细胞定位：
    Cytoplasmic vesicle.
  • 组织特异性：
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed more abundantly in heart, pancreas and skeletal muscle.
  • 数据库链接：

    HGNC: 19357

    OMIM: 612275

    KEGG: hsa:79893

    STRING: 9606.ENSP00000307617

    UniGene: Hs.514116