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  4. Recombinant Human Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1), partial

Recombinant Human Gamma-aminobutyric acid receptor subunit beta-1 (GABRB1), partial

  • 中文名称：
    人GABRB1重组蛋白
  • 货号：
    CSB-YP009146HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GABRB1重组蛋白
  • 货号：
    CSB-EP009146HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GABRB1重组蛋白
  • 货号：
    CSB-EP009146HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GABRB1重组蛋白
  • 货号：
    CSB-BP009146HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GABRB1重组蛋白
  • 货号：
    CSB-MP009146HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GABRB1
  • Uniprot No.：
  • 别名：
    AW061132; B230208N19Rik; GABA(A) receptor beta 1; GABA(A) receptor subunit beta-1; GABA-A receptor; beta-1 polypeptide; Gabrb-1; GABRB1; Gamma aminobutyric acid (GABA) A receptor beta 1; Gamma Aminobutyric Acid A Receptor Beta 1; Gamma Aminobutyric Acid Receptor ; beta-1; Gamma-aminobutyric acid (GABA) A receptor; subunit beta 1; Gamma-aminobutyric acid receptor subunit beta-1; GARB1; GBRB1_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.
  • 基因功能参考文献：
    1. No allelic association was detected in this study between tested SNPs and risk for developing alcohol dependence in a British and Irish population; however, modest genotypic associations were found with several intronic GABRbeta1 SNPs that may directly influence alcohol dependence risk or may be in linkage disequilibrium with causal risk variants in nearby genes, including other GABA receptor subunits PMID: 28346242
    2. Results from genome-wide DNA methylation, functional network analysis and pyrosequencing, show selective CpG sites (NOS1AP, BID, and GABRB1) differentially methylated in smokers and chronic obstructive pulmonary disease patients compared to nonsmokers. PMID: 28416970
    3. PCDHB14- and GABRB1-like nervous system developmental genes are altered during early neuronal differentiation of NCCIT cells treated with ethanol PMID: 25566775
    4. This study showed that in male group the expression of GABRB1 was generally lower in schizophrenia cases compared to the control, but was higher in female group. PMID: 25660468
    5. Both mRNA and protein of GABAB receptor subunits, GABAB1 and GABAB2, were co-expressed in cultured human RPE cells; GABAB receptors regulate the [Ca2+]i via a pertussis toxin-sensitive Gi/o-protein pathway and a phospholipase C pathway PMID: 25241062
    6. study provides the first evidence for the involvement of the GABRB1 gene in the thalamus structure and their interactive effects on intelligence PMID: 25192656
    7. This study demonstrates altered patterns of N-glycosylation of GABRB1 in the temporal lobe in schizophrenia. PMID: 23917429
    8. GABRB1 protein levels were significantly decreased in schizophrenia, major depressive disorder, and bipolar disorder patients' lateral cerebellum compared to controls. PMID: 24022508
    9. These results suggest that epigenetic control of gene expression may affect the expression of GABRB1 and disrupt inhibitory synaptic transmission during embryonic development. PMID: 23392927
    10. Gaba-A receptor subunit beta1 is not involved in amygdala hyperexcitability of patients with temporal lobe epilepsy. PMID: 20848605
    11. Gaba (A) beta1 and beta3 subunit mRNA levels in the dorsolateral prefrontal cortex are not altered in schizophrenia. PMID: 20843900
    12. linkage disequilibrium between beta frequency of EEG and a set of GABA(A) receptor genes PMID: 11891318
    13. A signal for GABA A beta 1 isoform mRNA transcript could not be detected in the competitive RT-PCR assay. PMID: 15337300
    14. histamine modulates heteromultimeric GABA(A) receptors and may thus represent an endogenous ligand for an allosteric site PMID: 18281286
    15. three distinct sets of amino acid residues in the N-terminal extracellular domain of the hbeta1 subunit, which when mutated to the homologous residue in hbeta3 allow expression as a functional homomeric receptor PMID: 18650446

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  • 相关疾病：
    Epileptic encephalopathy, early infantile, 45 (EIEE45)
  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRB1 sub-subfamily
  • 数据库链接：

    HGNC: 4081

    OMIM: 137190

    KEGG: hsa:2560

    STRING: 9606.ENSP00000295454

    UniGene: Hs.254117