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  4. Recombinant Human Gamma-aminobutyric acid receptor subunit rho-1 (GABRR1), partial

Recombinant Human Gamma-aminobutyric acid receptor subunit rho-1 (GABRR1), partial

  • 中文名称：
    人GABRR1重组蛋白
  • 货号：
    CSB-YP009156HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GABRR1重组蛋白
  • 货号：
    CSB-EP009156HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GABRR1重组蛋白
  • 货号：
    CSB-EP009156HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GABRR1重组蛋白
  • 货号：
    CSB-BP009156HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GABRR1重组蛋白
  • 货号：
    CSB-MP009156HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GABRR1
  • Uniprot No.：
  • 别名：
    bA135P14.1 (gamma-aminobutyric acid (GABA) receptor rho 1); GABA(A) receptor subunit rho-1; GABA(C) receptor; GABRR1; gamma aminobutyric acid receptor rho 1; gamma-aminobutyric acid (GABA) A receptor rho-1; gamma-aminobutyric acid (GABA) receptor rho 1; Gamma-aminobutyric acid receptor subunit rho-1; GBRR1_HUMAN; MGC163216
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.
  • 基因功能参考文献：
    1. GABAergic genes interacting with parenting in adolescent depressive symptoms: GABRR1 X perceived parental support interaction. PMID: 28660714
    2. Study determined that levels of GABAA receptors rho1 and rho2 are not altered in the cerebellum of WT and rho1 knockin mice. In addition, findings show that mutation of the inhibitory ethanol site in rho1 does not alter normal channel function, but is important for the development of acute tolerance to ethanol-induced motor impairment. PMID: 28623169
    3. The most common polymorphisms in the GABRR genes seemed to be not associated with the risk for migraine in Caucasian Spanish people, although one of them (GABRR1 rs1186902) shows a statistically significant association with the age of onset of migraine. PMID: 28699326
    4. Thr244 of rho1 GABAC Receptors is an important residue for channel activation as it forms a H-bond with agonists, initiating the conformational changes required for priming of the receptor and stabilizes the open conformation (review). PMID: 27244450
    5. Data indicate that all compounds from the study exhibited increased selectivity for GABAC. PMID: 23755849
    6. The function of GABA(C) receptors can be enhanced by nitric oxide acting at the extracellular Cys-loop. PMID: 22747884
    7. evidence supporta the involvement of histaminergic and gamma-aminobutyric acidergic mechanisms in the etiology of TS and show an overlap of rare CNVs in TS and autism spectrum disorder. PMID: 22169095
    8. found no significant differences in either the frequencies of the GABRR1-M26V, GABRR1- H27R, GABRR2-T455M, and GABRR3-Y205X genotypes or in the frequencies of the allelic variants of these polymorphisms in patients with essential tremor PMID: 20820800
    9. GABRR1 is associated with susceptibility to bipolar disorder with schizophrenia-like psychotic features PMID: 20583128
    10. GABRR1 and GABRR2 encode the GABA-A receptor subunits rho1 and rho2 and are associated with alcohol dependence PMID: 19536785
    11. Data show that GABArho1 can tolerate removal of several residues that form the fourth transmembrane segment up to a critical point, signaled by W475, beyond which the mutant protein is translated but does not form functional receptors. PMID: 20056107
    12. examination of receptor modulation by divalent cations PMID: 11862606
    13. Tyr-102 is a component of the GABA binding domain and it might be important for coupling agonist binding to channel opening PMID: 12226075
    14. a single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism PMID: 15163459
    15. a complete model of the GABA(C) receptor binding pocket was proposed and discussed in comparison with the GABA(A) receptor binding pocket PMID: 15548535
    16. GABA receptor subunit rho-1 effectively altered gene expression through its interaction with the cellular retinoic acid binding protein pathway PMID: 16198491
    17. Charge selectivity of the anionic rho1 GABA receptor can be influenced by the introduction of glutamates, one at a time, over an 8-amino acid stretch (-2' to 5') in the proposed intracellular end of TM2 and the TM1-TM2 intracellular linker. PMID: 18079559
    18. Results imply that the M3M4 loop is not essential for GABA rho1 receptor assembly and function and suggest that the cytoplasmic domain may fold as an independent module from the transmembrane and extracellular domains. PMID: 18227272
    19. Structural determinants for antagonists that distinguish the GABRR1 receptor from GABA-A receptors are reported. PMID: 18599601
    20. These functional data support negative cross-talk between P2X(4) and rho1 receptors. PMID: 18675255
    21. Nonsense mutations of GABA(A) receptor are associated with genetic epilepsies. PMID: 19717338

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRR1 sub-subfamily
  • 组织特异性：
    Highly expressed in the retina and in a lesser extent in brain, lung and thymus.
  • 数据库链接：

    HGNC: 4090

    OMIM: 137161

    KEGG: hsa:2569

    STRING: 9606.ENSP00000412673

    UniGene: Hs.99927