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  4. Recombinant Human Gamma-aminobutyric acid receptor subunit rho-2 (GABRR2), partial

Recombinant Human Gamma-aminobutyric acid receptor subunit rho-2 (GABRR2), partial

  • 中文名称：
    人GABRR2重组蛋白
  • 货号：
    CSB-YP009157HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GABRR2重组蛋白
  • 货号：
    CSB-EP009157HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GABRR2重组蛋白
  • 货号：
    CSB-EP009157HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GABRR2重组蛋白
  • 货号：
    CSB-BP009157HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GABRR2重组蛋白
  • 货号：
    CSB-MP009157HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GABRR2
  • Uniprot No.：
  • 别名：
    GABRR2; Gamma-aminobutyric acid receptor subunit rho-2; GABA(A) receptor subunit rho-2; GABA(C) receptor
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission.
  • 基因功能参考文献：
    1. GABAergic genes interacting with parenting in adolescent depressive symptoms: GABRR2 X perceived parental support interaction. PMID: 28660714
    2. The genetic variant of GABRR2 gene contributes to the difference of individuals' general cognitive ability in a Chinese Han population. PMID: 26922432
    3. GABRR2 and CHRNA3 were found to be differentially expressed after risperidone treatment. These genes may be regulated by antipsychotic use. PMID: 24113126
    4. association between serum creatinine level and polymorphisms in the collagen type XXII alpha 1 (COL22A1) gene, on chromosome 8, and in the synaptotagmin-1 (SYT1) gene, on chromosome 12 PMID: 20222955
    5. Molecular modeling of ligand-receptor interactions of gamma-aminobutyric acid type C receptor rho1, human. PMID: 19167917

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRR2 sub-subfamily
  • 数据库链接：

    HGNC: 4091

    OMIM: 137162

    KEGG: hsa:2570

    STRING: 9606.ENSP00000386029

    UniGene: Hs.379330