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  4. Recombinant Human Gastrokine-2 (GKN2)

Recombinant Human Gastrokine-2 (GKN2)

  • 货号：
    CSB-YP803147HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP803147HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP803147HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP803147HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP803147HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GKN2
  • Uniprot No.：
  • 别名：
    BLOT; Blottin; BRICD1B; BRICHOS domain containing 1B; Down regulated in gastric cancer GDDR; Down-regulated in gastric cancer; Gastrokine-2; GDDR; Gkn2; GKN2_HUMAN; PRO813; TFIZ1; Trefoil factor interactions(z) 1; UNQ465/PRO813; VLTI465
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    21-184
  • 氨基酸序列
    YEVFNIISPS NNGGNVQETV TIDNEKNTAI INIHAGSCSS TTIFDYKHGY IASRVLSRRA CFILKMDHQN IPPLNNLQWY IYEKQALDNM FSSKYTWVKY NPLESLIKDV DWFLLGSPIE KLCKHIPLYK GEVVENTHNV GAGGCAKAGL LGILGISICA DIHV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Co-expression of GKN2 and TFF1 massively suppressed the expression of positive cell cycle regulators and induced G1/S arrest, synergistically enhancing the inhibition of cell viability and proliferation of gastric cancer cells PMID: 28150071
    2. These findings suggested that GDDR expression was significantly associated with the progression of gastric cancer and GDDR may function as a tumor suppressor via inhibiting the epithelial-mesenchymal transition. PMID: 27017226
    3. Our results suggested, for the first time, that the gradual change in GDDR expression might not only be directly related to H. pylori infection but also be an early molecular event in the development of gastric carcinoma. PMID: 26842925
    4. GKN2 suppressed epithelial mesenchymal transition of gastric cancer cells by downregulation of snail through PI3K/AKT/GSK3beta signaling pathway. PMID: 27323966
    5. these results reveal an antiinflammatory role for GKN2, provide in vivo evidence that links GKN2 loss to GC pathogenesis, and suggest GKN restoration as a strategy to restrain GC progression. PMID: 26974160
    6. the gestational age-dependent and compartment-specific expression pattern of GKN2 points to a role for placental development PMID: 26070363
    7. GKN2 could inhibit the proliferation, migration, and invasion of gastric cancer cells and might represent a novel therapeutic target for gastric cancer. PMID: 24408014
    8. gastrointestinal tract specific gene GDDR might inhibit gastric cancer growth in a TFF1 dependent manner PMID: 21870107
    9. GKN2 was expressed in 33 non-tumoral mucosae (66%) and 35 tumoral mucosae (70%). PMID: 21151392
    10. TFIZ1 is an 18.31 kDa binding partner of trefoil factor 1 (TFF1) protein in normal gastric mucosa; it contains an approximately 100 amino acid brichos domain and has homology with surfactant protein C. (TFIZ1; trefoil factor interactions 1) PMID: 15924415
    11. The TFF1-GKN2 heterodimer and TFF2 differ characteristically by their binding to gastric mucins. PMID: 17982272
    12. in gastric cancer, expression of TFF1 in the absence of TFIZ1 is associated with lymph node metastasis PMID: 18722547

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  • 亚细胞定位：
    Secreted.
  • 组织特异性：
    Expressed in gastric mucosa.
  • 数据库链接：

    HGNC: 24588

    KEGG: hsa:200504

    STRING: 9606.ENSP00000329292

    UniGene: Hs.16757