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  4. Recombinant Human Glucose-6-phosphate translocase (SLC37A4), partial

Recombinant Human Glucose-6-phosphate translocase (SLC37A4), partial

  • 货号：
    CSB-YP021613HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021613HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021613HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021613HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021613HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC37A4
  • Uniprot No.：
  • 别名：
    G6PT1; G6PT1_HUMAN; G6PT2; G6PT3; Glucose-5-phosphate transporter; Glucose-6-phosphatase; transport (glucose) protein 3; Glucose-6-phosphatase; transport (glucose-6-phosphate) protein 1; Glucose-6-phosphatase; transport (phosphate/pyrophosphate) protein 2,; Glucose-6-phosphate translocase; Glucose-6-phosphate transporter 1; GSD1b; GSD1c; GSD1d; MGC15729; Microsomal glucose-6-phosphate transporter; PRO0685; SLC37A4; Solute carrier family 37 (glucose-6-phosphate transporter); member 4; Solute carrier family 37 member 4; Transformation-related gene 19 protein; TRG-19; TRG19
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.
  • 基因功能参考文献：
    1. Study demonstrates that G6PT is essential for proliferation and differentiation of adipose-derived mesenchymal stem cells , providing important insights into the GSD-Ib phenotypes. PMID: 29238966
    2. We report the MFRP-related ocular phenotype in three siblings with glycogen storage disease type 1b. Molecular genetic studies identified novel mutations in the MFRP and SLC37A4 genes. PMID: 28511025
    3. The most common mutation of SLC37A4 genes identified in Korean patients was c.443C>T (p.Ala148Val), accounting for 55.6% (5/9 patients) of all GSD Ib patients and 38.9% of the tested alleles PMID: 28224773
    4. Data suggest that G6PT modulates autophagy independent of its transport activity; G6PT appears to up-regulate autophagy via inactivation of mTORC1; knockdown of G6PT expression activates mTORC1 (mechanistic target of rapamycin complex 1) activity. PMID: 25982172
    5. Five SLC37A4 gene mutations were detected in 7 (25%) of the 28 children PMID: 23965881
    6. A total of 11 SLC37A4 gene mutations were identified in 15 families of the mainland of China. The frequent mutations are p.Pro191Leu, p.Gly149Glu and c.870 + 5G > A. PMID: 21575371
    7. Two novel mutations were identified in these samples: one had a novel mutation (25C>T); the remaining sample carried a 49 bp deletion in intron 12. PMID: 21446359
    8. Our results suggest that in Sardinia, Glycogen storage disease Ib is caused by only one mutational event in the G6PT gene, further suggesting that Sardinia is a founder population. PMID: 20578944
    9. operates by a similar antiport mechanism as its E. coli homologue, namely, the substrate binds at the N- and C-terminal domain interface and is then transported across the membrane via a rocker-switch type of movement of the two domains PMID: 15260472
    10. mutational analysis of G6PT1 in type I glycogen storage disease PMID: 16435186
    11. Overexpression of recombinant glucose-6-phosphate translocase rescued the cells from curcumin-induced cell death [ glucose-6-phosphate translocase] PMID: 16777101
    12. A novel G6PT1 promoter polymorphism, 259C --> T was found; the - 259*T allele frequency was greater in term SIDS infants than in term control infants and preterm SIDS infants PMID: 17354259
    13. A molecular signaling axis regulates the invasive phenotype of brain tumor cells and highlights a new bioswitch function for glucose-6-phosphate transporter (G6PT) in cell survival. PMID: 17460777
    14. Targeted inhibition of either MT1-MMP or G6PT may lead to reduced infiltrative and invasive properties of brain tumor cells. PMID: 18267120
    15. Human G6PT contains 10-transmembrane helices and is more probable than the bacterial Uhp that contains 12-transmembrane helices. PMID: 19008136

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  • 相关疾病：
    Glycogen storage disease 1B (GSD1B); Glycogen storage disease 1C (GSD1C); Glycogen storage disease 1D (GSD1D)
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family
  • 组织特异性：
    Mostly expressed in liver and kidney.
  • 数据库链接：

    HGNC: 4061

    OMIM: 232220

    KEGG: hsa:2542

    UniGene: Hs.719203