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  4. Recombinant Human Glutamate-rich WD repeat-containing protein 1 (GRWD1)

Recombinant Human Glutamate-rich WD repeat-containing protein 1 (GRWD1)

  • 中文名称：
    人GRWD1重组蛋白
  • 货号：
    CSB-YP860655HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GRWD1重组蛋白
  • 货号：
    CSB-EP860655HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GRWD1重组蛋白
  • 货号：
    CSB-EP860655HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GRWD1重组蛋白
  • 货号：
    CSB-BP860655HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GRWD1重组蛋白
  • 货号：
    CSB-MP860655HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GRWD1
  • Uniprot No.：
  • 别名：
    CDW4; CUL4 and DDB1 associated WDR protein 4; Glutamate rich WD repeat containing 1; Glutamate rich WD repeat containing protein 1; Glutamate rich WD repeat protein GRWD; Glutamate-rich WD repeat-containing protein 1; GRWD 1; GRWD; grwd1; GRWD1_HUMAN; KIAA1942; METTL18; Regulator of ribosome biogenesis 1 homolog; RRB 1; RRB1; WD repeat domain 28; WDR 28; WDR28
  • 种属：
    Homo sapiens (Human)
  • 表达区域：
    1-446
  • 氨基酸序列
    MAARKGRRRT CETGEPMEAE SGDTSSEGPA QVYLPGRGPP LREGEELVMD EEAYVLYHRA QTGAPCLSFD IVRDHLGDNR TELPLTLYLC AGTQAESAQS NRLMMLRMHN LHGTKPPPSE GSDEEEEEED EEDEEERKPQ LELAMVPHYG GINRVRVSWL GEEPVAGVWS EKGQVEVFAL RRLLQVVEEP QALAAFLRDE QAQMKPIFSF AGHMGEGFAL DWSPRVTGRL LTGDCQKNIH LWTPTDGGSW HVDQRPFVGH TRSVEDLQWS PTENTVFASC SADASIRIWD IRAAPSKACM LTTATAHDGD VNVISWSRRE PFLLSGGDDG ALKIWDLRQF KSGSPVATFK QHVAPVTSVE WHPQDSGVFA ASGADHQITQ WDLAVERDPE AGDVEADPGL ADLPQQLLFV HQGETELKEL HWHPQCPGLL VSTALSGFTI FRTISV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histone binding-protein that regulates chromatin dynamics and minichromosome maintenance (MCM) loading at replication origins, possibly by promoting chromatin openness.
  • 基因功能参考文献：
    1. GRWD1 overexpression in combination with HPV16 E7 and activated KRAS confers anchorage-independent growth and tumorigenic capacity on normal human fibroblasts. Consistent with this, GRWD1 overexpression is associated with poor prognosis in cancer patients. PMID: 27856536
  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus. Chromosome.
  • 数据库链接：

    HGNC: 21270

    OMIM: 610597

    KEGG: hsa:83743

    STRING: 9606.ENSP00000253237

    UniGene: Hs.400625