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  4. Recombinant Human Glutaminyl-peptide cyclotransferase-like protein (QPCTL), partial

Recombinant Human Glutaminyl-peptide cyclotransferase-like protein (QPCTL), partial

In Stock
  • 中文名称：
    人QPCTL重组蛋白
  • 货号：
    CSB-EP868351HU
  • 规格：
    ￥1344
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    QPCTL
  • Uniprot No.：
  • 别名：
    QPCTLGlutaminyl-peptide cyclotransferase-like protein; EC 2.3.2.5; Golgi-resident glutaminyl-peptide cyclotransferase; isoQC; gQC
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 来源：
    E.coli
  • 分子量：
    35.5kDa
  • 表达区域：
    212-382aa
  • 氨基酸序列
    AAPVTLQLLFLDGEEALKEWGPKDSLYGSRHLAQLMESIPHSPGPTRIQAIELFMLLDLLGAPNPTFYSHFPRTVRWFHRLRSIEKRLHRLNLLQSHPQEVMYFQPGEPFGSVEDDHIPFLRRGVPVLHLISTPFPAVWHTPADTEVNLHPPTVHNLCRILAVFLAEYLGL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 6xHis-SUMO-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 产品描述：

    The Human QPCTL recombinant protein is conventionally generated by transfecting the recombinant DNA into a host cell, and then the host cells are cultured and the transfected DNA transcribed and translated. Different host cells can be chosen for recombinant protein production, the choice of which depends on the type of protein that needs to be generated, its functional activity and requisite yield. We choose E.coli as the expression system for this QPCTL protein expression because bacteria cells are easy to culture, grow fast and produce high yields of recombinant protein.

    QPCTL is a protein coding gene that encodes Golgi-resident glutaminyl-peptide cyclotransferase (isoQC). According to some studies, QPCTL may have the following features.
    Two insertion variants in the promoter region of the QPCTL gene were significantly associated with chicken body weight and carcass traits. QPCTL knockout mice show different substrate turnover for glutamine cyclase isoenzymes. QPCTL is essential for pyroglutamate formation at the SIRPα binding site on CD47 shortly after biosynthesis. The QPCT transcript level was higher in thyroid cancer, whereas the expression of the QPCTL gene was not affected.

  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Responsible for the biosynthesis of pyroglutamyl peptides.
  • 基因功能参考文献：
    1. genetic association studies in Danish population: Quantitative metabolic phenotypes in obesity are associated with SNP in various genes: QPCTL (rs2287019) is associated with body mass index and increased insulinogenic index. PMID: 21953277
  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Glutaminyl-peptide cyclotransferase family
  • 数据库链接：

    HGNC: 25952

    KEGG: hsa:54814

    STRING: 9606.ENSP00000012049

    UniGene: Hs.631556