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  4. Recombinant Human Glutathione S-transferase Mu 2 (GSTM2)

Recombinant Human Glutathione S-transferase Mu 2 (GSTM2)

  • 货号：
    CSB-YP009981HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009981HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009981HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009981HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009981HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GSTM2
  • Uniprot No.：
  • 别名：
    Glutathione S alkyltransferase M2; Glutathione S aralkyltransferase M2; Glutathione S aryltransferase M2; Glutathione S transferase 4; Glutathione S transferase M1; Glutathione S transferase M2 (muscle); Glutathione S transferase Mu 2 (muscle); Glutathione S transferase Mu 2; Glutathione S-transferase Mu 2; GST class mu 2; GST class-mu 2; GST muscle; GST4; GSTM; GSTM2; GSTM2-2; GSTM2_HUMAN; GTHMUS; MGC117303; S (hydroxyalkyl)glutathione lyase M2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-218
  • 氨基酸序列
    PMTLGYWNI RGLAHSIRLL LEYTDSSYEE KKYTMGDAPD YDRSQWLNEK FKLGLDFPNL PYLIDGTHKI TQSNAILRYI ARKHNLCGES EKEQIREDIL ENQFMDSRMQ LAKLCYDPDF EKLKPEYLQA LPEMLKLYSQ FLGKQPWFLG DKITFVDFIA YDVLERNQVF EPSCLDAFPN LKDFISRFEG LEKISAYMKS SRFLPRPVFT KMAVWGNK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Participates in the formation of novel hepoxilin regioisomers.
  • 基因功能参考文献：
    1. GST-M2 exhibited high frequency of promoter hypermethylation in lung cancer cells, CpG hypermethylation abated Sp1 binding to the GST-M2 promoter in lung cancer PMID: 21246532
    2. it was noted that the alpha-6 helix of GST-C plays a stabilising role in the fold of this domain. By destabilising the conformation of GST-C, an increase in cell translocation efficiency of up to approximately 2-fold was observed. PMID: 21455499
    3. analysis of active-site residues and modulation of catalytic functions in GST-M2 PMID: 21454564
    4. High GSTM2 is associated with mesenchymal stem-like cells derived from ovarian teratoma. PMID: 21268265
    5. The structure of helix 6 in the carboxyl-terminal fold is critical to GSTM2-2's inhibitory action on the cardiac ryanodine receptor. PMID: 20417188
    6. GST-M2 may play an important future role in lowering the incidence of benzo[a]pyrene-diolepoxide-induced DNA damage. PMID: 15725629
    7. CVD risk was higher in smokers compared to non-smokers with GSTT1-1. No significant associations were observed by GSTM1. PMID: 16002077
    8. A significant association was found between oxidative stress GSTM1 deletion and the HMOX-1 long repeat and heart rate variation in response to particulate air pollution. PMID: 18007994
    9. hGSTM2-2 modifies both cardiac & skeletal ryanodine receptor (RyR) activity when it binds to luminal domain of RyR channel complex. GSTM2-2 can interact with specific luminal sites on RyR complex & interaction is likely to be within pore of RyR channel. PMID: 18308613
    10. children with variants in GSTM2 (glutathione S-transferase mu 2) were more susceptible to effects of in utero tobacco smoke exposure on lung function PMID: 19151192
    11. The active center of GSTM2-2 for inhibition of cardiac ryanodine receptors involves the helix6 sequence and is essential for its efficacy. PMID: 19168034

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GST superfamily, Mu family
  • 组织特异性：
    Muscle.
  • 数据库链接：

    HGNC: 4634

    OMIM: 138380

    KEGG: hsa:2946

    STRING: 9606.ENSP00000241337

    UniGene: Hs.279837