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  4. Recombinant Human Glycodelin (PAEP)

Recombinant Human Glycodelin (PAEP)

  • 货号：
    CSB-YP017381HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP017381HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP017381HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PAEP
  • Uniprot No.：
  • 别名：
    Alpha uterine protein; gD; GdA; GdF; GdS; Glycodelin A; Glycodelin; Glycodelin F; Glycodelin S; MGC138509; MGC142288; PAEG; PAEP; PAEP_HUMAN; PEG; PEP; Placental Protein 14 / Glycodelin A; Placental protein 14; PP14; Pregnancy-associated endometrial alpha-2 globulin; Progestagen-associated endometrial protein; Progesterone-associated endometrial protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    19-180
  • 氨基酸序列
    MD IPQTKQDLEL PKLAGTWHSM AMATNNISLM ATLKAPLRVH ITSLLPTPED NLEIVLHRWE NNSCVEKKVL GEKTENPKKF KINYTVANEA TLLDTDYDNF LFLCLQDTTT PIQSMMCQYL ARVLVEDDEI MQGFIRAFRP LPRHLWYLLD LKQMEEPCRF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities. Glycodelin-C stimulates binding of spermatozoa to the zona pellucida. Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa. Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa.
  • 基因功能参考文献：
    1. serum levels higher in preeclamptic group as compared to controls and higher in severe than in mild preeclampsia PMID: 28738719
    2. This study indicate that GdA is a complex glycoprotein including up to 6 different glycoforms specifically expressed during the different phase of the menstrual cycle; in pathologic conditions such as endometriosis, the expression profile is altered possibly related to the impaired endometrial receptivity. PMID: 28683601
    3. The results from the present study suggested that PP14 may be a novel potential biomarker for PPROM, and may be developed into a lateral flow assay for bedside application to rapidly diagnose PPROM. PMID: 29749501
    4. PKCdelta, via MAPK pathway, is involved in the glycodelin-driven cell differentiation. PMID: 27373413
    5. inverse relationship between glycodelin immunostaining and cervical intraephitelial neoplasia grade in pregnant patients PMID: 26631447
    6. the role of glycodelin-A in placental development and fetomaternal tolerance in early pregnancy. PMID: 26757357
    7. Altogether, the comprehensive characterization of glycodelin in non-small cell lung cancer provides strong support for its use as a biomarker with immune modulatory function. PMID: 25901080
    8. The current study investigates the role of melanoma cell-secreted PAEP protein in regulating T cell function. PMID: 25785839
    9. The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans. PMID: 25422905
    10. Glycodelin-A treatment reduces the adverse effect of macrophage co-culture on human sperm motility. PMID: 24733737
    11. Three months after myomectomy, endometrial glycodelin levels are significantly increased in infertile women with myoma. PMID: 24518545
    12. Glycodelin-A binds to KLF11 and is differentially activated and repressed by KLF11 in ovarian endometrium. PMID: 24060634
    13. Gd and GdA are commonly expressed in endometrial cancer tissue and seem to be of relevance in tumourigenesis. PMID: 24377825
    14. Results suggest that PP-14 may play an important role in the pathogenesis of endometriosis. PMID: 23670949
    15. Serum glycodelin levels did not predict endometrial receptivity in patients undergoing in vitro fertilization. PMID: 23585335
    16. Glycodelin-A is a potentially useful biomarker for ovarian endometriosis PMID: 23461865
    17. The glycodelin A sequence from Met24 to Leu105 is necessary and sufficient to inhibit proliferation of T cells and induce apoptosis in them. PMID: 23392770
    18. Glycodelin A was found to be an independent prognostic marker for poor prognosis in advanced ovarian cancer patients. PMID: 23036050
    19. Data suggest that, in post-menarche girls (13-19 years) with endometriosis, peritoneal fluid levels of glycodelin A, IL-6 (interleukin-6), and TNF-alpha (tumor necrosis factor-alpha) are significantly higher than in control subjects. PMID: 22563871
    20. GdA reduces the surface expression of the high-affinity IL-2R complex by down-regulating the synthesis of IL-2Ralpha (CD25). PMID: 22313865
    21. GdA induces translocation of beta-catenin molecules promoting cell-to-cell adhesion and formation of adherents junctions through cytoskeletal reorganization and promoting angiogenesis. PMID: 21999200
    22. Native glycodelin-A binds to peripheral blood monocytes inducing interleukin-6 secretion through L-selectin. PMID: 22977256
    23. data suggest a possible function of glycodelin-A in mediating cytotrophoblast differentiation PMID: 22748851
    24. A significant association between tumoral levels of glycodelin and AhR (p=0.002) in breast cancers. PMID: 22296396
    25. Preoperative glycodelin is lower in patients with uterine polyps than in menorrhagia, but increase postoperatively. This could explain the pathophysiological mechanisms for impaired endometrial receptivity in the presence of endometrial polyps. PMID: 22239027
    26. glycodelin plays an important role in the pathogenesis of lung cancer and lung metastases PMID: 21168900
    27. GdA interacts with Siglec-6 to suppress trophoblast invasiveness by down-regulating the ERK/c-Jun signaling pathway. PMID: 21880722
    28. Gene expression analysis revealed a correlation between progestagen-associated endometrial protein expression in sporadic and familial non-BRCA1/2 breast cancers PMID: 20676758
    29. At ovulation (day LH + 1), glycodelin concentration is increased in endometrium (and thus in endometrial flushing fluid) of infertile women with abnormal fallopian tubes compared to fertile controls. PMID: 21292383
    30. GdA (not GdC, GdS, or deglycosylated GdA) up-regulates expression of Fas, suppresses MAPK signaling, and enhances cell death in isolated Th-1 cells (but not Th-2 cells). These data suggest GdA may contribute to Th-2/Th-1 shift as seen in pregnancy. PMID: 21227941
    31. significant differences in glycodelin and IL-10 between the fibroid and the control group suggesting that submucous fibroids may have an adverse effect on endometrial receptivity. PMID: 20880745
    32. PP14 arrests T cells in a unique activated state that is not accompanied with the acquisition of effector function. PMID: 20886106
    33. we propose that GdA in the oviductal fluid binds to spermatozoa, potentiating them for zona pellucida-induced acrosome reaction via the cAMP/PKA/ERK/IP3R1 pathway PMID: 20843776
    34. These data strongly implicate the PAEP gene as a tumour growth promoter with oncogenic properties and a potential therapeutic target for patients with advanced melanoma. PMID: 19799645
    35. GdA plays a protective role during pregnancy by regulating the cytolytic activity of CD8(+) T cells. PMID: 20638131
    36. glycodelin-A contributes to the cytokine shift in early pregnancy PMID: 19945098
    37. analysis of glycodelin expression in correlation to grading, nodal involvement and steroid receptor expression in human breast cancer patients PMID: 20592348
    38. glycodelin-A expression is correlated to grading and staging in ovarian carcinoma tissue PMID: 20592354
    39. enables the spermatozoa to become more competent in fertilization; review PMID: 19857900
    40. In the endometrium, both Glycodelin and Plexin-B1 are exhibiting a cyclic pattern suggesting a possible steroid regulation and a role in endometrial receptivity PMID: 20040080
    41. Patients with severe dysmenorrhoea had increased peritoneal fluid TNF-alpha and glycodelin. TNF-alpha and glycodelin may play role in endometriosis and severity of menstrual pain. PMID: 19903048
    42. Synthesized in the granulosa cells at late secondary follicle stage; function in the ovarian follicle PMID: 11818517
    43. PP14 is a soluble regulatory protein that dampens T cell responses by its physical presence in the contact site at the time of T cell receptor triggering. PMID: 11884441
    44. uterine glycodelin flushings are elevated in patients with both polyps and leiomyomas; elevated glycodelin levels in the follicular and peri-ovulatory period may impair fertilization and implantation PMID: 12351556
    45. new immunoregulatory model for PP14: one of its surface molecular targets, CD45, mediates its T cell inhibitory activity, accounting for the intriguing capacity of PP14 to elevate TCR activation thresholds and thereby down-regulate T cell activation PMID: 12556471
    46. Oxidants and antioxidants affect the expression of glycodelin PMID: 12654469
    47. ZIF-1 is a differentially glycosylated isoform of glycodelin that potently inhibits human sperm-egg interaction. PMID: 12672671
    48. PP14 as a soluble regulatory factor capable of interacting with both T and B cells in a carbohydrate-dependent manner and as a result it can affect both cellular and humoral immune responses. PMID: 12826085
    49. protein is apoptotically inactive in the non-sialylated form: differential glycosylation modulates the function of the different glycodelin isoforms. PMID: 14679205
    50. During first trimester, serum glycodelin and IGFBP-1 are markedly decreased in polycystic ovary syndrome(PCOS), implicating endometrial epithelial and stromal dysfunction during periimplantation and early pregnancy in early pregnancy loss. PMID: 14764802

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Calycin superfamily, Lipocalin family
  • 组织特异性：
    This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy. Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at
  • 数据库链接：

    HGNC: 8573

    OMIM: 173310

    KEGG: hsa:5047

    STRING: 9606.ENSP00000277508

    UniGene: Hs.532325