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  4. Recombinant Human Glypican-5 (GPC5)

Recombinant Human Glypican-5 (GPC5)

  • 中文名称：
    人GPC5重组蛋白
  • 货号：
    CSB-YP009707HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人GPC5重组蛋白
  • 货号：
    CSB-EP009707HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人GPC5重组蛋白
  • 货号：
    CSB-EP009707HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人GPC5重组蛋白
  • 货号：
    CSB-BP009707HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人GPC5重组蛋白
  • 货号：
    CSB-MP009707HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GPC5
  • Uniprot No.：
  • 别名：
    bA93M14.1; glypican 5; Glypican 5 precursor ; glypican proteoglycan 5; Glypican-5; GPC5; GPC5_HUMAN; Secreted glypican-5
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    -
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cell surface proteoglycan that bears heparan sulfate.
  • 基因功能参考文献：
    1. Our results showed that GPC5 was lowly expressed in PCa cell lines. PMID: 28893348
    2. Taken together, our results suggest GPC5 as a tumor suppressor in PDAC and its expression is possibly regulated by miR-4295. Our study indicates that the miR-4295/GPC5 axis may play an important role in the pathogenesis of PADC and has potential applications for the development of PDAC therapy. PMID: 29407175
    3. Suggest that GPC5 is able to suppress the lung adenocarcinoma metastasis by competitively binding to Wnt3a and inactivating the Wnt/beta-catenin signaling pathway. PMID: 27806326
    4. GPC5 is a novel epigenetically silenced tumor suppressor, which inhibits tumor growth by suppressing Wnt/beta-catenin signaling in lung adenocarcinoma. PMID: 27157618
    5. GPC5 protein expression showed a close correlation with the tumorigenesis and tumor progression of prostate cancer, and that might be applied as a novel biomarker for the prediction of diagnosis and prognosis of prostate cancer. PMID: 26631038
    6. These results suggest that miR-297 acted as an oncogenic miRNA, partly by targeting GPC5, adenocarcinoma of the lung. PMID: 27554041
    7. Results suggest a potential association between CRP and GPC5 variants with lung cancer risk; variation in GKN1 is associated with chemotherapy response in the Chinese Han population. PMID: 25999661
    8. miR-709 may positively regulate invasion and metastasis of hepatocellular carcinoma through targeting GPC5. PMID: 25818666
    9. gene variants in IRF5, IRF8 and GPC5 were not associated with risk of relapse or disease progression in multiple sclerosis PMID: 24943672
    10. GPC5, a tumor suppressor, is regulated by miR-620 in lung adenocarcinoma. PMID: 24682381
    11. Variants in the 50-upstream region of GPC5 confer risk of lung cancer in never smokers PMID: 24456789
    12. These results indicate that GPC5 polymorphisms would be useful genetic indicators for Inflammatory demyelinating diseasess, including neuromyelitis optica and multiple sclerosis . PMID: 24135429
    13. The IL7R, TNFRSF1A, and GPC5 polymorphisms tended to be associated with having a second event of Multiple sclerosis within a year. PMID: 24130709
    14. Shh binds to HSPG co-receptors containing a glypican 5 core and 2-O-sulfo-iduronic acid to promote neural precursor proliferation. PMID: 23867465
    15. Data suggest that glypican-5 (GPC5) is a metastasis suppressor gene in non-small cell lung cancer (NSCLC) and may be a potential biomarker that predicts NSCLC metastasis. PMID: 23962560
    16. GPC5 is a gene required for normal neural tube development. PMID: 23223018
    17. findings suggested that SNP rs2352028 in GPC5 might confer a slight risk to lung cancer/adenocarcinoma PMID: 22236185
    18. GPC5 stimulates Hh signaling by facilitating/stabilizing the interaction between Hh and Ptc1. PMID: 21339334
    19. GPC5 is a novel genetic locus protective against sudden cardiac arrest PMID: 20360844
    20. This study supports that multiple sclerosis susceptibility at 13q31-32 may localize to the Glypican-5 gene. PMID: 20692050
    21. No association between GPC5rs2352028 variant and lung cancer in never smokers in meta-analysis of 7 genome-wide association studies under the random effects model. PMID: 20688270
    22. GPC5 polymorphism associated with susceptibility to lung cancer in never smokers PMID: 20304703
    23. GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines. PMID: 12721791
    24. Independent replication confirms GPC5 as a genetic risk factor for multiple sclerosis. PMID: 19010793
    25. ZIC2, SPRY2, and GPC5 genes are candidate genes suspected to explain the malformations associated with cerebral anomalies in the hypothesis of a contiguous gene syndrome in 13q deletion syndrome PMID: 19022413
    26. Confirm the association of polymorphisms within GPC5 with response to interferon-beta therapy in patients with multiple sclerosis. PMID: 19556317
    27. Genome-wide association study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 18195134

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; [Secreted glypican-5]: Secreted, extracellular space.
  • 蛋白家族：
    Glypican family
  • 组织特异性：
    In adult, primarily expressed in the brain. Also detected in fetal brain, lung and liver.
  • 数据库链接：

    HGNC: 4453

    OMIM: 602446

    KEGG: hsa:2262

    STRING: 9606.ENSP00000366267

    UniGene: Hs.655675