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  4. Recombinant Human HIV Tat-specific factor 1 (HTATSF1)

Recombinant Human HIV Tat-specific factor 1 (HTATSF1)

  • 货号：
    CSB-YP010872HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010872HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010872HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010872HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010872HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HTATSF1
  • Uniprot No.：
  • 别名：
    HTATSF1HIV Tat-specific factor 1; Tat-SF1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-755
  • 氨基酸序列
    SGTNLDGND EFDEQLRMQE LYGDGKDGDT QTDAGGEPDS LGQQPTDTPY EWDLDKKAWF PKITEDFIAT YQANYGFSND GASSSTANVE DVHARTAEEP PQEKAPEPTD ARKKGEKRKA ESGWFHVEED RNTNVYVSGL PPDITVDEFI QLMSKFGIIM RDPQTEEFKV KLYKDNQGNL KGDGLCCYLK RESVELALKL LDEDEIRGYK LHVEVAKFQL KGEYDASKKK KKCKDYKKKL SMQQKQLDWR PERRAGPSRM RHERVVIIKN MFHPMDFEDD PLVLNEIRED LRVECSKFGQ IRKLLLFDRH PDGVASVSFR DPEEADYCIQ TLDGRWFGGR QITAQAWDGT TDYQVEETSR EREERLRGWE AFLNAPEANR GLRRSDSVSA SERAGPSRAR HFSEHPSTSK MNAQETATGM AFEEPIDEKK FEKTEDGGEF EEGASENNAK ESSPEKEAEE GCPEKESEEG CPKRGFEGSC SQKESEEGNP VRGSEEDSPK KESKKKTLKN DCEENGLAKE SEDDLNKESE EEVGPTKESE EDDSEKESDE DCSEKQSEDG SEREFEENGL EKDLDEEGSE KELHENVLDK ELEENDSENS EFEDDGSEKV LDEEGSEREF DEDSDEKEEE EDTYEKVFDD ESDEKEDEEY ADEKGLEAAD KKAEEGDADE KLFEESDDKE DEDADGKEVE DADEKLFEDD DSNEKLFDEE EDSSEKLFDD SDERGTLGGF GSVEEGPLST GSSFILSSDD DDDDI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus.
  • 基因功能参考文献：
    1. This study validates Tat-SF1 as an HDF in CD4+ T cell-derived SupT1 cells. PMID: 23153325
    2. these findings suggest that Tat-SF1 functions independently in transcription and splicing of cellular genes. PMID: 21282347
    3. These results support the notion that Tat-induced neuropathogenesis is mediated by multiple mechanisms involving both intracellular and extracellular Tat protein. PMID: 15050687
    4. phosphorylated by P-TEFb kinase during HIV-1 transcription in Tat/TAR dependent manner PMID: 15564463
    5. Intracellular HIV-1 Tat protein represses constitutive LMP2 transcription increasing proteasome activity by interfering with the binding of IRF-1 to STAT1 PMID: 16512786
    6. Tat-SF1 is not required for regulating HIV-1 transcription, but is required for maintaining the ratios of different classes of HIV-1 transcripts. PMID: 19479034

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    HTATSF1 family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 5276

    OMIM: 300346

    KEGG: hsa:27336

    STRING: 9606.ENSP00000218364

    UniGene: Hs.204475