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  4. Recombinant Human Heparan sulfate glucosamine 3-O-sulfotransferase 2 (HS3ST2), partial

Recombinant Human Heparan sulfate glucosamine 3-O-sulfotransferase 2 (HS3ST2), partial

  • 中文名称：
    人HS3ST2重组蛋白
  • 货号：
    CSB-YP897083HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HS3ST2重组蛋白
  • 货号：
    CSB-EP897083HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HS3ST2重组蛋白
  • 货号：
    CSB-EP897083HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HS3ST2重组蛋白
  • 货号：
    CSB-BP897083HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HS3ST2重组蛋白
  • 货号：
    CSB-MP897083HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HS3ST2
  • Uniprot No.：
  • 别名：
    HS3ST2; 3OST2; UNQ2442/PRO5004Heparan sulfate glucosamine 3-O-sulfotransferase 2; EC 2.8.2.29; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 2; 3-OST-2; Heparan sulfate 3-O-sulfotransferase 2; h3-OST-2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in GlcA2S-GlcNS. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
  • 基因功能参考文献：
    1. In primary macrophages, HS3ST2 was clearly visualized at the plasma membrane. Its truncated form remained in the Golgi apparatus, meaning that the catalytic domain might support correct addressing of HS3ST2 to cell surface. HS3ST2 partly co-localized with syndecan-2 in HeLa cells and primary macrophages suggesting that this enzyme may participate in discrete processes that occur at the cell surface. PMID: 29660372
    2. HS3ST2 and CCNA1 genes may play important roles in HPV-induced cervical cancer and patients with specific hypermethylated genes may have a greater risk of progressing to invasive cervical cancer. PMID: 25198553
    3. By interacting with tau at the intracellular level, the 3-O-sulphated heparan sulphates produced by HS3ST2 might act as molecular chaperones allowing the abnormal phosphorylation of tau PMID: 25842390
    4. HS3ST2 hypermethylation may be an independent prognostic indicator for overall survival in node-negative stage I-II NSCLC PMID: 24265783
    5. These results showed that silencing of 3-OST-2 was present in a wide range of human cancersFrom the high incidence, silencing of the 3-OST-2 gene is expected to have high diagnostic, and potentially therapeutic, values. PMID: 12527896
    6. results raise the possibility of a role of 3-OST-2 in the spread of HSV-1 infection in the brain PMID: 16336986

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  • 亚细胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Sulfotransferase 1 family
  • 组织特异性：
    Highly expressed in the brain and weakly expressed in the heart, placenta, lung and skeletal muscle.
  • 数据库链接：

    HGNC: 5195

    OMIM: 604056

    KEGG: hsa:9956

    STRING: 9606.ENSP00000261374

    UniGene: Hs.115830