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  4. Recombinant Human Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)

Recombinant Human Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)

  • 中文名称：
    人HNRNPA3重组蛋白
  • 货号：
    CSB-YP010603HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HNRNPA3重组蛋白
  • 货号：
    CSB-EP010603HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HNRNPA3重组蛋白
  • 货号：
    CSB-BP010603HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HNRNPA3重组蛋白
  • 货号：
    CSB-MP010603HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HNRNPA3
  • Uniprot No.：
  • 别名：
    HNRNPA3; HNRPA3; Heterogeneous nuclear ribonucleoprotein A3; hnRNP A3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-378
  • 氨基酸序列
    MEVKPPPGRP QPDSGRRRRR RGEEGHDPKE PEQLRKLFIG GLSFETTDDS LREHFEKWGT LTDCVVMRDP QTKRSRGFGF VTYSCVEEVD AAMCARPHKV DGRVVEPKRA VSREDSVKPG AHLTVKKIFV GGIKEDTEEY NLRDYFEKYG KIETIEVMED RQSGKKRGFA FVTFDDHDTV DKIVVQKYHT INGHNCEVKK ALSKQEMQSA GSQRGRGGGS GNFMGRGGNF GGGGGNFGRG GNFGGRGGYG GGGGGSRGSY GGGDGGYNGF GGDGGNYGGG PGYSSRGGYG GGGPGYGNQG GGYGGGGGYD GYNEGGNFGG GNYGGGGNYN DFGNYSGQQQ SNYGPMKGGS FGGRSSGSPY GGGYGSGGGS GGYGSRRF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in cytoplasmic trafficking of RNA. Binds to the cis-acting response element, A2RE. May be involved in pre-mRNA splicing.
  • 基因功能参考文献：
    1. This study showed that HNRNPA3 variants identified in Australian patients with familial amyotrophic lateral sclerosis (FALS) and associated alternate allele frequencies in cases and controls. PMID: 29131108
    2. Study investigated the pattern of hnRNP A1, A2/B1 and A3 immunostaining across a range of clinical, pathological and genetic forms of Frontotemporal Lobar Degeneration and Motor Neurone Disease. Data suggest there might be a derangement of movement of hnRNP A1, and other hnRNP proteins, across all pathological forms of Frontotemporal Lobar Degeneration beyond that involving just TDP-43 or FUS. PMID: 28431575
    3. Neurons in the hippocampus of C9orf72 patients are frequently devoid of hnRNPA3. Reduced nuclear hnRNPA3 in the hippocampus of patients with extended C9orf72 repeats correlates with increased DPR deposition. PMID: 27461252
    4. The results of this study suggested that mutations in hnRNPA1, A2/B1, and A3 genes are a rare finding in amyotrophic lateral sclerosis. PMID: 23827524
    5. characterization of hnRNP A3 in human and mouse cell lines PMID: 22546510
    6. Results suggest that hnRNP A3 is associated with telomere in vivo and acts as a negative regulator of telomere length maintenance. PMID: 20600361
    7. These biochemical properties of hnRNP A3 suggest that hnRNP A3 can participate in telomere regulation in vivo. PMID: 17919748

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  • 亚细胞定位：
    Nucleus. Note=Component of ribonucleosomes.
  • 数据库链接：

    HGNC: 24941

    OMIM: 605372

    KEGG: hsa:220988

    STRING: 9606.ENSP00000376309

    UniGene: Hs.516539