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  4. Recombinant Human High affinity cationic amino acid transporter 1 (SLC7A1), partial

Recombinant Human High affinity cationic amino acid transporter 1 (SLC7A1), partial

  • 货号：
    CSB-YP021709HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021709HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021709HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021709HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021709HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    SLC7A1
  • Uniprot No.：
  • 别名：
    Amino acid transporter cationic 1; ATRC1; CAT-1; CaT1; CTR1_HUMAN; Ecotropic retroviral leukemia receptor homolog; Ecotropic retroviral receptor; Ecotropic retrovirus receptor homolog; ERR; HCAT1; High affinity cationic amino acid transporter 1; High-affinity cationic amino acid transporter-1; REC1L; Slc7a1; Solute carrier family 7 (cationic amino acid transporter, y+ system) member 1; Solute carrier family 7 member 1; System Y+ basic amino acid transporter
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues.
  • 基因功能参考文献：
    1. Estradiol increases arginine transport and CAT-1 activity through modulation of constitutive signaling transduction pathways involving ERK. Progesterone inhibits arginine transport and CAT-1 via both PKCalpha and ERK1/2 phosphorylation. PMID: 26062636
    2. The rs41318021 polymorphism in the SLC7A1 gene was not associated with essential hypertension in 50-year-old subjects. PMID: 23841815
    3. Overexpression of arginine transporter CAT-1 is associated with accumulation of L-arginine and cell growth in human colorectal cancer tissue. PMID: 24040099
    4. CAT1, CAT2, and CAT3 localized in adult brains but with uneven distribution. PMID: 22870827
    5. mRNA levels for high-affinity CAT-1, expressed as a percentage of the wild-type value, are increased by an average 12% and 32% in mdx and transgenic mdx:utr mice respectively. PMID: 23009292
    6. The data demonstrates that CAT1 significantly (but most likely not exclusively) contributes to the cellular uptake of asymmetric dimethylarginine. PMID: 22705145
    7. In hypoxic human pulmonary microvascular endothelial cells, overexpression of CAT-1 resulted in significantly greater L-arginine transport and NO production PMID: 21923750
    8. In acute congestive heart failure acute renal impairment function and the modulation of metabolism and extracellular transport by the DDAH-1/CAT-1 system determine high ADMA and SDMA levels after therapy for acute congestive heart failure. PMID: 21722652
    9. Insulin increased hCATs-L-arginine transport, maximal transport capacity, and hCAT-1 expression. Sp1 nuclear protein abundance and binding to DNA, and SLC7A1 promoter activity was increased by insulin. PMID: 21302286
    10. Data show that the CAT-1 isoform plays a role in arginine uptake. PMID: 21308737
    11. PKC activation also resulted in ubiquitination of CAT-1 PMID: 21212261
    12. analysis of the genomic organization PMID: 11665818
    13. Stable polarized expression of hCAT-1 in an epithelial cell line. PMID: 11891586
    14. Keratinocytes express cationic amino acid transporters 1 and 2. Cationic amino acid transporter mediated L-arginine essential for inducible nitric oxide synthase and arginase enzyme, which modulate proliferation and differentiation of epidermal cells. PMID: 12787129
    15. Insulin-mediated stimulation of the L-arginine/NO pathway is thus associated with increased hCAT-1 and hCAT-2B mRNA, and eNOS expression PMID: 15064952
    16. Glomerular arginine uptake is elevated through modulation of CAT-1 expression, thus, contributing to the pathogenesis of hyperfiltration. Increased nitric oxide formation may play a role in this process. PMID: 15086470
    17. protein kinase C(PKC) did not phosphorylate human cationic amino acid transporter hCAT-1 directly as evidenced by in vivo phosphorylation experiments and mutational analysis, indicating an indirect action of PKC on hCAT-1 PMID: 15491978
    18. The CAT-1 is thought to supply substrate to endothelial NOS by virtue of its co-localisation with this enzyme. PMID: 15631944
    19. The present study identifies a key functionally active polymorphism in the 3'UTR of SLC7A1 [which] may account for the apparent link between altered endothelial function, L-arginine, and nitric oxide metabolism and predisposition to essential hypertension PMID: 17325243
    20. Ornithine uptake in retinal pigment epithelium is depdendent on induction of SLC7A1 mRNA and spermine. PMID: 17494634
    21. distribution of human cationic amino acid transporters 1 (hCAT1) and 2 (hCAT2) in healthy skin and compared it to psoriatic skin lesions by means of immunohistochemistry PMID: 18172665
    22. CAT1 is directly involved in erythropoiesis through supplying arginine to the blood cells. PMID: 18574322
    23. Data provide novel insights into the mechanism by which ss52051869 influences SLC7A1 gene expression. PMID: 19067360

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amino acid-polyamine-organocation (APC) superfamily, Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 11057

    OMIM: 104615

    KEGG: hsa:6541

    STRING: 9606.ENSP00000370128

    UniGene: Hs.14846