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  4. Recombinant Human Histatin-1 (HTN1)

Recombinant Human Histatin-1 (HTN1)

  • 中文名称：
    人HTN1重组蛋白
  • 货号：
    CSB-YP010878HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HTN1重组蛋白
  • 货号：
    CSB-EP010878HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HTN1重组蛋白
  • 货号：
    CSB-EP010878HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HTN1重组蛋白
  • 货号：
    CSB-BP010878HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HTN1重组蛋白
  • 货号：
    CSB-MP010878HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HTN1
  • Uniprot No.：
  • 别名：
    HTN1; HIS1; Histatin-1; Histidine-rich protein 1; Post-PB protein; PPB) [Cleaved into: His1-(31-57)-peptide; His1 31/57; His1-(12-38)-peptide; His1 12/38; Histatin-2)]
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    20-57
  • 氨基酸序列
    D SHEKRHHGYR RKFHEKHHSH REFPFYGDYG SNYLYDN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Histatins are salivary proteins that are considered to be major precursors of the protective proteinaceous structure on tooth surfaces (enamel pellicle). In addition, histatins exhibit antibacterial and antifungal activities.
  • 基因功能参考文献：
    1. salivary histatin-1 is a novel proangiogenic factor that may contribute to oral wound healing PMID: 28751526
    2. This study evaluated the effects of Hst1 on cellular barrier function. Hst1 counteracted the effects of epithelial-mesenchymal transition inducers on the outgrowth of oral cancer cell spheroids, suggesting that Hst1 affects processes that are implicated in cancer progression. PMID: 28522595
    3. Histatin-1 is specifically expressed in human lacrimal epithelium. PMID: 26824896
    4. Histatins are salivary proteins with antimicrobial activity. PMID: 2303595
    5. We investigated interactions among and functions of histatin 1 and the other proteins that are present in saliva by using high-throughput mass spectrometric techniques. This led to the identification of 43 proteins able to interact with histatin 1. PMID: 23001880
    6. inhibits calcium phosphate precipitation PMID: 12060866
    7. The results allowed locating sulfation on the last four tyrosines (Tyr 27, 30, 34, and 36). PMID: 17503797
    8. histatin 1 (Hst1) and histatin 2 (Hst2) as major wound-closing factors in human saliva PMID: 18650243
    9. These findings indicate that the regulation of the histatin gene expression may be intricate, and it seems to have a cell-type preference in the salivary gland cells. PMID: 19060311

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Histatin/statherin family
  • 组织特异性：
    Submandibular and parotid glands.
  • 数据库链接：

    HGNC: 5283

    OMIM: 142701

    KEGG: hsa:3346

    STRING: 9606.ENSP00000246896

    UniGene: Hs.250959