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  4. Recombinant Human Histidine decarboxylase (HDC)

Recombinant Human Histidine decarboxylase (HDC)

  • 货号：
    CSB-EP010246HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010246HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010246HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010246HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Name:HDC
  • Uniprot No.：
  • 别名：
    DCHS_HUMAN; EC 4.1.1.22; HDC; Histidine decarboxylase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-662
  • 氨基酸序列
    MMEPEEYRER GREMVDYICQ YLSTVRERRV TPDVQPGYLR AQLPESAPED PDSWDSIFGD IERIIMPGVV HWQSPHMHAY YPALTSWPSL LGDMLADAIN CLGFTWASSP ACTELEMNVM DWLAKMLGLP EHFLHHHPSS QGGGVLQSTV SESTLIALLA ARKNKILEMK TSEPDADESC LNARLVAYAS DQAHSSVEKA GLISLVKMKF LPVDDNFSLR GEALQKAIEE DKQRGLVPVF VCATLGTTGV CAFDCLSELG PICAREGLWL HIDAAYAGTA FLCPEFRGFL KGIEYADSFT FNPSKWMMVH FDCTGFWVKD KYKLQQTFSV NPIYLRHANS GVATDFMHWQ IPLSRRFRSV KLWFVIRSFG VKNLQAHVRH GTEMAKYFES LVRNDPSFEI PAKRHLGLVV FRLKGPNCLT ENVLKEIAKA GRLFLIPATI QDKLIIRFTV TSQFTTRDDI LRDWNLIRDA ATLILSQHCT SQPSPRVGNL ISQIRGARAW ACGTSLQSVS GAGDDPVQAR KIIKQPQRVG AGPMKRENGL HLETLLDPVD DCFSEEAPDA TKHKLSSFLF SYLSVQTKKK TVRSLSCNSV PVSAQKPLPT EASVKNGGSS RVRIFSRFPE DMMMLKKSAF KKLIKFYSVP SFPECSSQCG LQLPCCPLQA MV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the biosynthesis of histamine from histidine.
  • 基因功能参考文献：
    1. Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. This review summarizes the analogies and differences in their origin as well as their common pathophysiological scenarios. [review] PMID: 27769832
    2. a Possible Role for the Histidine Decarboxylase Gene in Tourette Syndrome in the Chinese Han Population PMID: 27529419
    3. Human enterochromaffin-like cells appear to partially co-express VMAT-2 and HDC. Co-expression of VMAT-2 and HDC might be required for increased histamine production in patients with gastric neuroendocrine tumors. PMID: 26715806
    4. The findings indicate that polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer. PMID: 24835231
    5. HDC rs17740607 polymorphism is at least a partial loss-of-function variant and acts as a protective factor against chronic heart failure PMID: 25846768
    6. Investigated variation across the HDC (histidine decarboxylase) gene for association with Tourette Syndrome. PMID: 23825391
    7. HDC production in the stomach is associated with bile acid exposure and its related transcriptional regulation network of FXR, SHP, and CDX1. PMID: 24415870
    8. Data indicate that histidine decarboxylase (HDC) is expressed by neutrophils. PMID: 23572231
    9. Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. PMID: 22767596
    10. crystal of histidine decarboxylase belonged to space group C2, with unit-cell parameters a = 215.16, b = 112.72, c = 171.39 A, beta = 110.3 degrees PMID: 22684068
    11. It was shown that for serum and urine, HDC levels achieved sensitivities and specificities compatible to or even greater than those of established biomarkers for the diagnosis of intestinal mucosal injury in patients with acute intestinal obstruction. PMID: 21915437
    12. The novel concept that an autocrine loop, consisting of enhanced histamine synthesis by histidine decarboxylase, sustains cholangiocarcinoma growth is proposed. PMID: 21873469
    13. Variants in the HDC gene may play little or no role in Tourette Syndrome susceptibility in Chinese Han population. PMID: 22095709
    14. Studies provide lead compounds for inhibitors of ornithine decarboxylase and human histidine decarboxylase. PMID: 21454364
    15. The histidine decarboxylase allele Glu644 in homozygosity increases the risk of developing rhinitis in the studied population PMID: 20608921
    16. identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis which points to its role in Tourette's syndrome and tics PMID: 20445167
    17. the elevation of HDC expression during human monocytic differentiation PMID: 11556524
    18. HDC expression is regulated by gastrin through a complex cis-acting element, which binds at least three distinct nuclear factors PMID: 12372397
    19. Histidine decarboxylase promoter activity can be repressed by kruppel-like factor 4 PMID: 14670968
    20. histidine decarboxylase mRNA is found in human vascular smooth muscle and endothelial cells PMID: 15167966
    21. HDC and histamine content were significantly higher in the tumor specimens PMID: 15928846
    22. Chronic urticaria expresses high levels of HDC as compared to normal foreskin, breast skin and cultured human keratinocytes. PMID: 16297195
    23. HDC expression and histamine production are increased in the superficial kidney cortex zone during pregnancy PMID: 16760908
    24. Defective levels found in normal placenta compared with pre-eclampsia labor. PMID: 16822545
    25. Synthesis of histamine was found to be restricted to the basophil compartment of the CML clone and to depend on signaling through the PI3-kinase pathway. CML cells also expressed histamine receptors PMID: 16849647
    26. HDC SNP's are significantly associated with age at natural menopause in Caucasian women. PMID: 16919600
    27. Histamine decarboxylase expressed in endothelial cells of microvessels might play a role in regulating angiogenesis in esophageal squamous cell carcinomas. PMID: 19133005
    28. HFR was regulated by HIF-1 activation. Depletion of HIF-1alpha prevents hypoxic induction of HDC in BMMCs. Hypoxia induces HDC expression by transcriptional mechanisms dependent upon HIF-1. PMID: 19266161
    29. the apparent occurrence of an unusual TG 3' splice site in intron 4 is discussed PMID: 17672918

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  • 蛋白家族：
    Group II decarboxylase family
  • 数据库链接：

    HGNC: 4855

    OMIM: 142704

    KEGG: hsa:3067

    STRING: 9606.ENSP00000267845

    UniGene: Hs.1481