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  4. Recombinant Human Homeobox protein DLX-4 (DLX4)

Recombinant Human Homeobox protein DLX-4 (DLX4)

  • 中文名称：
    人DLX4重组蛋白
  • 货号：
    CSB-YP821718HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人DLX4重组蛋白
  • 货号：
    CSB-EP821718HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人DLX4重组蛋白
  • 货号：
    CSB-EP821718HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人DLX4重组蛋白
  • 货号：
    CSB-BP821718HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人DLX4重组蛋白
  • 货号：
    CSB-MP821718HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DLX4
  • Uniprot No.：
  • 别名：
    Beta protein 1; BP1; Distal less homeo box 7; Distal less homeo box 9; distal-less homeobox 4; DLX4; DLX4_HUMAN; DLX7; DLX8; DLX9; Homeobox protein DLX-4; Homeobox protein DLX-7; Homeobox protein DLX-8; Homeobox protein DLX4
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-240
  • 氨基酸序列
    MTSLPCPLPG RDASKAVFPD LAPVPSVAAA YPLGLSPTTA ASPNLSYSRP YGHLLSYPYT EPANPGDSYL SCQQPAALSQ PLCGPAEHPQ ELEADSEKPR LSPEPSERRP QAPAKKLRKP RTIYSSLQLQ HLNQRFQHTQ YLALPERAQL AAQLGLTQTQ VKIWFQNKRS KYKKLLKQNS GGQEGDFPGR TFSVSPCSPP LPSLWDLPKA GTLPTSGYGN SFGAWYQHHS SDVLASPQMM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis.
  • 基因功能参考文献：
    1. Beta protein 1 (BP1) binds to and regulates estrogen receptor. PMID: 27449292
    2. study indicated that DLX4 hypermethylation was a frequent event and acted as an independent prognostic biomarker in de novo myelodysplastic syndrome patients PMID: 26485746
    3. Our study reveals that BP1 overexpression serves as an independent risk factor in de novo AML patients. PMID: 26325005
    4. Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1beta and NF-kappaB signaling. PMID: 26208636
    5. DLX4 induces CD44 by stimulating IL-1beta-mediated NF-kappaB activity, thereby promoting peritoneal metastasis of ovarian cancer PMID: 26067154
    6. This first finding of a DLX4 mutation in a family with Cleft lip and/or palate establishes DLX4 as a potential cause of human clefts PMID: 25954033
    7. DLX4 promotes ovarian tumor angiogenesis in part by stimulating iNOS expression. PMID: 25924901
    8. Aberrant DNA methylation of the DLX4 and SIM1 genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions. PMID: 25614457
    9. indicate that gains of DLX4 and ERBB2 occur in South African breast cancer patients irrespectively of their race and factors known to influence prognosis PMID: 26524685
    10. a DLX4 overexpression vector lacking the 3'UTR was shown to abolish miR-122-induced inhibition of proliferation in the HCC cell line Hep3B. PMID: 25823567
    11. DLX4 can functionally replace c-MYC. PMID: 25471527
    12. Methylated DLX4 is a potential biomarker that predicts poor prognosis after curative resection of pathologic stage I Non-Small Cell Lung Cancer. PMID: 25825198
    13. DLX4 increased copy number was observed in 21.6% of the primary breast tumors and 24.3% of the sentinel lymph node metastasis PMID: 24947980
    14. The results suggest that high expression of DLX4 predicts hepatocellular carcinoma prognosis. PMID: 24824934
    15. All trans retinoic acid can inhibit the proliferation and the expression of BP1 in breast cancer cells. PMID: 23158431
    16. DLX4 induces cancer cells to undergo epithelial to mesenchymal transition through TWIST, enhancing tumor migration, invasion and metastasis. PMID: 23091415
    17. findings suggest that decreased expression of homeobox protein DLX-4 leads to the pathogenesis of preeclampsia by inhibiting epithelial-mesenchymal transition in trophoblasts PMID: 21602546
    18. The ability of DLX4 to counteract key transcriptional control mechanisms of the TGF-beta cytostatic program could explain, in part, the resistance of tumors to the antiproliferative effect of TGF-beta. PMID: 21297662
    19. BP1, a homeodomain-containing isoform of DLX4, represses the beta-globin gene. PMID: 11909945
    20. involvement of BP1 in the mechanism of the negative regulation of beta-globin transcription. PMID: 15308321
    21. BP1 can negatively modulate adult beta-globin gene expression and definitive erythroid cell differentiation, and suggest that BP1 could play a role in thalassemia. PMID: 17003054
    22. Increased expression of homeobox gene DLX4 may be a contributing factor to the developmental abnormalities seen in the FGR-affected placentae. PMID: 17062780
    23. we were able to show that enforced expression of the DLX4 homeobox gene markedly inhibited in vitro motility and invasion as well as in vivo metastasis via both hematogenous and lymphogenous routes. PMID: 17260014
    24. results support the notion that BP1 might contribute to breast neoplastic transformation or tumor progression and suggest for the first time that BP1 mRNA level has potential as a prognostic predictor for breast cancer PMID: 17999690
    25. BP1 may regulate bcl-2 and c-myc expression PMID: 18026954
    26. BP1 may be part of a pathway contributing to non-small cell lung cancer (NSCLC) development and/or progression and mRNA level could be a novel prognostic marker for NSCLC. PMID: 18420035
    27. BP1 is an important upstream factor in the carcinogenic pathway of prostate cancer and that the expression of BP1 may reflect or directly contribute to tumor progression and/or invasion. PMID: 18931648
    28. Other mechanisms in addition to gene amplification play a role in BP1 protein expression om breast camcer/ PMID: 18992636
    29. High BP1 expression is associated with inflammatory breast cancer and tumor aggressiveness PMID: 19242057

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  • 相关疾病：
    Non-syndromic orofacial cleft 15 (OFC15)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Distal-less homeobox family
  • 组织特异性：
    Expressed in leukemia cells and placenta. Also expressed in kidney and fetal liver.
  • 数据库链接：

    HGNC: 2917

    OMIM: 601911

    KEGG: hsa:1748

    STRING: 9606.ENSP00000240306

    UniGene: Hs.591167