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  4. Recombinant Human Homeobox protein EMX2 (EMX2)

Recombinant Human Homeobox protein EMX2 (EMX2)

  • 中文名称：
    人EMX2重组蛋白
  • 货号：
    CSB-YP007657HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人EMX2重组蛋白
  • 货号：
    CSB-EP007657HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人EMX2重组蛋白
  • 货号：
    CSB-EP007657HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人EMX2重组蛋白
  • 货号：
    CSB-BP007657HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人EMX2重组蛋白
  • 货号：
    CSB-MP007657HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EMX2
  • Uniprot No.：
  • 别名：
    Empty spiracles homeobox 2; Empty spiracles homolog 2 (Drosophila); Empty spiracles homolog 2; Empty spiracles like protein 2; Empty spiracles-like protein 2; EMX 2; EMX2; EMX2_HUMAN; Homeobox protein EMX 2; Homeobox protein EMX2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-252
  • 氨基酸序列
    MFQPAPKRCF TIESLVAKDS PLPASRSEDP IRPAALSYAN SSPINPFLNG FHSAAAAAAG RGVYSNPDLV FAEAVSHPPN PAVPVHPVPP PHALAAHPLP SSHSPHPLFA SQQRDPSTFY PWLIHRYRYL GHRFQGNDTS PESFLLHNAL ARKPKRIRTA FSPSQLLRLE HAFEKNHYVV GAERKQLAHS LSLTETQVKV WFQNRRTKFK RQKLEEEGSD SQQKKKGTHH INRWRIATKQ ASPEEIDVTS DD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system.
  • 基因功能参考文献：
    1. EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival. PMID: 28830374
    2. Emx2 is a novel promising tool for therapy of glioblastoma and prevention of its recurrences. PMID: 27191499
    3. EMX2 inhibits proliferation and tumorigenesis through inactivation of the Wnt/beta-catenin pathway in CRC cells. PMID: 27712600
    4. EMX2 expression was down-regulated in lung SCC tissue compared to matched adjacent normal tissue. EMX2 expression was associated with improved overall survival. Knockdown promoted chemo-resistance and cell migration. PMID: 26132438
    5. Although it is uncommon (0.19%), EMX2 is the first gene identified that if perturbed may cause isolated incomplete mullerian fusion. PMID: 25577462
    6. Deletions of EMX2 have been associated with a wide range of DSD. PMID: 24975717
    7. EMX2 expression is downregulated in advanced cases of malignant pleural mesothelioma and may serve as an important prognostic and predictive molecular biomarker of progression-free survival. PMID: 25023662
    8. downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer PMID: 23370654
    9. EMX2 expression led to inhibition of cell proliferation and Wnt signaling pathway both in vitro and in a gastric cancer xenograft model in vivo. PMID: 23029345
    10. Study analyzed mutations of EMX2 gene in 45 prostate carcinomas, 51 non-small cell lung cancers, 43 gastric carcinomas, 44 colorectal carcinomas, and 43 breast carcinomas by polymerase chain reaction and single-strand conformation polymorphism assay. PMID: 21917011
    11. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma. PMID: 21726823
    12. Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1. PMID: 21651764
    13. promoter. Restoration of EMX2 expression in lung cancer cells lacking endogenous EMX2 expression suppressed cell proliferation and invasive phenotypes PMID: 20697358
    14. EMX2 gene has been reported in schezencephaly (cleft brain) including epilepsy in some patients. PMID: 12185771
    15. In these studies we identify and characterize the regulation of EMX2 by HOXA10. PMID: 12482956
    16. Endometrial EMX2 expression is aberrant in women with endometriosis and is mediated by altered HOXA10 expression. PMID: 15126568
    17. EMX2 levels in cortical progenitors of EMX2 transgenic mice disproportionately specify sizes and positions of primary cortical areas. PMID: 15294144
    18. It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis. PMID: 17563403
    19. provide results of EMX2 sequencing in 39 new schizencephaly patients, detecting no pathogenic mutations PMID: 18409201
    20. These data support recent reports that EMX2 but not PAX6 is more directly involved in arealization, highlighting that analysis of human development allows better spatio-temporal resolution than studies in rodents. PMID: 18973570

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  • 相关疾病：
    Schizencephaly (SCHZC)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    EMX homeobox family
  • 组织特异性：
    Cerebral cortex.
  • 数据库链接：

    HGNC: 3341

    OMIM: 269160

    KEGG: hsa:2018

    STRING: 9606.ENSP00000358202

    UniGene: Hs.202095