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  4. Recombinant Human Homeobox protein Hox-A1 (HOXA1)

Recombinant Human Homeobox protein Hox-A1 (HOXA1)

  • 中文名称：
    人HOXA1重组蛋白
  • 货号：
    CSB-YP010647HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HOXA1重组蛋白
  • 货号：
    CSB-EP010647HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HOXA1重组蛋白
  • 货号：
    CSB-EP010647HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HOXA1重组蛋白
  • 货号：
    CSB-BP010647HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HOXA1重组蛋白
  • 货号：
    CSB-MP010647HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXA1
  • Uniprot No.：
  • 别名：
    BSAS; Homeo box A1; Homeobox 1F; Homeobox A1; Homeobox protein Hox A1; Homeobox protein Hox-1F; Homeobox protein Hox-A1; Hox 1.6 like protein; Hox 1F; HOX A1; HOX A1 homeodomain protein; HOX1; HOX1F; hoxa1; hoxb1b; HXA1_HUMAN; Lab like protein; MGC45232
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-335
  • 氨基酸序列
    MDNARMNSFL EYPILSSGDS GTCSARAYPS DHRITTFQSC AVSANSCGGD DRFLVGRGVQ IGSPHHHHHH HHHHPQPATY QTSGNLGVSY SHSSCGPSYG SQNFSAPYSP YALNQEADVS GGYPQCAPAV YSGNLSSPMV QHHHHHQGYA GGAVGSPQYI HHSYGQEHQS LALATYNNSL SPLHASHQEA CRSPASETSS PAQTFDWMKV KRNPPKTGKV GEYGYLGQPN AVRTNFTTKQ LTELEKEFHF NKYLTRARRV EIAASLQLNE TQVKIWFQNR RMKQKKREKE GLLPISPATP PGNDEKAEES SEKSSSSPCV PSPGSSTSDT LTTSH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor. Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior. Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments. Activates transcription in the presence of PBX1A and PKNOX1.
  • 基因功能参考文献：
    1. We speculate that HOXA1 may be the direct target of miR181b5p or miR181d5p in LUSC, and HOXA1 may serve a significant role in nonsmall cell lung cancer (NSCLC) by regulating various pathways, particularly the p53 signaling pathway. PMID: 29658571
    2. Study revealed the existence of negative correlation between the expression of miR577 and HOXA1 in hepatocellular carcinoma (HCC) specimens. HOXA1 expression is under the direct regulation of miR577 which is able to bind to its 3'UTR. PMID: 29693150
    3. HOTTIP cooperates with CTCF to coordinate HOXA gene expression. PMID: 29698677
    4. that miR-433 was frequently downregulated in colon cancer tissues and cell lines. Overexpression of miR-433 significantly inhibited the proliferation and invasion of colon cancer. We also newly identified HOXA1 as a direct target of miR-433. The effects of miR-433 on colon cancer cells were mediated via HOXA1. PMID: 29137689
    5. we found that KDM3B exhibits potential tumor-suppressive activity and transcriptionally modulates HOXA1 expression via RARE in AML. PMID: 28540746
    6. miR-30c could suppress giant cell tumor of bone cell proliferation and progression via HOXA1, which might provide a new target for giant cell tumor of bone diagnosis and therapy PMID: 29164581
    7. UBE2C and HOXA1 RNA and protein are differentially expressed in conventional and Spitz nevi and melanoma. PMID: 28657121
    8. Study identified HOXA1 as a direct target of miR-30e. Its expression is down-regulated by miR-30e played leading to suppressed lung cancer cell growth. PMID: 27992364
    9. HOXA1-mediated activation of NF-kappaB is non-transcriptional and the RBCK1 and TRAF2 influences on NF-kappaB are epistatic to HOXA1 PMID: 27382069
    10. Overexpression of the HOXA1 expression is associated with increased transformation of myelodysplastic syndrome into acute myeloid leukemia. PMID: 26812882
    11. Data indicated that HOXA1 and CCND1 mRNA and protein expression were higher in gastric cancer (GC) tissues, that a significant correlation was found between their expression, and they both may serve as a novel prognostic biomarker for GC. PMID: 26791264
    12. MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells. PMID: 26417931
    13. In a Middle Eastern population, HOXA1 is not likely a common cause of non-syndromic deafness. PMID: 24878468
    14. our findings suggest that HOXA1 is involved in the regulation of prostate cancer progression, including cell growth, migration, invasion and metastasis PMID: 26135141
    15. Studied HOTAIR in chemoresistance of SCLC and possible molecular mechanism. Knockdown of HOTAIR was carried out in SCLC multidrug-resistant cell lines; found depletion of HOTAIR reduced HOXA1 methylation by decreasing DNMT1 & DNMT3b expression. PMID: 26707824
    16. YAP regulates the expression of HOXA1 and HOXC13 in human keratinocytes. PMID: 25691658
    17. Analysis indicates that the genes BIRC5, HOXA1 and RARB are critical targets that play an important regulatory role in cervical cancer pathogenesis. PMID: 25069511
    18. ACK1 interacts with KDM3A to regulate the mammary tumor oncogene HOXA1. PMID: 25148682
    19. MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells. PMID: 24312487
    20. The results demonstrated that miR-181c transcription is suppressed and HOXA1 expression is enhanced in hepatitis C virus-infected hepatocytes. PMID: 24789793
    21. HOXA1-mediated SCLC chemoresistance is under the regulation of miR-100. HOXA1 may be a prognostic predictor and potential therapeutic target in human SCLC PMID: 24559685
    22. validation data and mechanistic insights suggest that patients whose primary tumors express HOXA1 are among a high-risk metastasis subgroup that should be considered for anti-TGFbeta therapy in adjuvant settings PMID: 23435427
    23. Data indicate that MiR-10a has a role in megakaryocyte differentiation of stem cells via HOXA1 transcription factor targeting. PMID: 23321646
    24. The findings in this patient raise the possibility that PTPRN2 may be active during early development of the human brainstem and that its overexpression may cause bilateral Duane retraction syndrome as occurs in patients with homozygous HOXA1 mutations. PMID: 22950449
    25. Overexpression of HOXA1 is associated with hepatocellular carcinoma. PMID: 22864671
    26. Loss of HOXA1 is associated with pancreatic cancer. PMID: 22407312
    27. study demonstrates KDM3A is overexpressed in various types of cancer and directly activates transcription of HOXA1 through demethylation of histone H3K9 by binding to its promoter region PMID: 22020899
    28. HOXA1 may contribute to oral carcinogenesis by increasing tumor cell proliferation, and suggest that HOXA1 expression might be helpful as a prognostic marker for patients with oral squamous cell carcinoma. PMID: 22498108
    29. the importance of the Hox-Pbx interaction for the oncogenic activity of Hoxa1 PMID: 21957483
    30. HOXA1 A218G and HOXB1 nINS/INS variants may not contribute significantly to autism spectrum disorders risk PMID: 21980499
    31. the combination of miR-377 and miR-217 help regulate HO-1 protein expression in the presence of hemin PMID: 21106538
    32. HOXA1 mutations are not a common cause of sporadic Mobius syndrome in the general population PMID: 20227628
    33. It is unlikely that HoxA1 plays a significant role in the genetic predisposition to autism. PMID: 11840501
    34. No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network PMID: 12210285
    35. hoxa1 protein plays a role in the development of infantile autism PMID: 12349873
    36. HOXA1 is a human mammary epithelial oncogene with aggressive in vivo tumor formation PMID: 12482855
    37. The HOXA1 A218G polymorphism explains approximately 5% of the variance in the head circumference of autistic patients and represents to our knowledge the first known gene variant providing sizable contributions to cranial morphology. PMID: 14960295
    38. Mutations in HOXA1 resulting in abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, mental retardation and autism spectrum disorder were identified. PMID: 16155570
    39. HOXA1 protein with polyhistidine tract expansions misfold, aggregate, and have a toxic effect on cell. PMID: 16168961
    40. HOXA1 is a downstream effector of E-cadherin-directed signaling required for anchorage-independent proliferation of mammary carcinoma cells. PMID: 16373333
    41. The HOXA1-related syndrome phenotype is variable; HOXA1 mutations are a rare cause of isolated Duane anomaly. PMID: 16528738
    42. Study reveals the preferential expression of HOXA1 by metaphase II oocytes. PMID: 16597639
    43. Expanded polyhistidine repeats in HOXA1 enhance aggregation and cell death, resulting in impaired neuronal differentiation and cooperative binding with PBX1. PMID: 17131398
    44. Variation not associated with autism in an Indian population. PMID: 17167333
    45. HOXA1 A218G alleles significantly influence head growth rates, but not final head size, in normal human development. PMID: 17171652
    46. Modulation of the p44/42 MAP kinase pathway is one mechanism by which HOXA1 mediates oncogenic transformation of the human mammary epithelial cell. PMID: 17213808
    47. This report extends the Bosley-Salih-Alorainy syndrome phenotype and documents the clinical variability resulting from identical HOXA1 mutations within an isolated ethnic population PMID: 17875913
    48. Results identified HOXA1 loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma. PMID: 17967182
    49. HOXA1 partially mediates oncogenic transformation of the immortalized human mammary epithelial cell through modulation of the STAT3 and STAT5B pathways. PMID: 18276758
    50. study describes nine previously unreported individuals from six families who have homozygous mutations of HOXA1 and either the Bosley-Salih-Alorainy syndrome (BSAS) or the Athabascan brainstem dysgenesis syndrome (ABDS) PMID: 18412118

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  • 相关疾病：
    Athabaskan brainstem dysgenesis syndrome (ABDS); Bosley-Salih-Alorainy syndrome (BSAS)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family, Labial subfamily
  • 数据库链接：

    HGNC: 5099

    OMIM: 142955

    KEGG: hsa:3198

    STRING: 9606.ENSP00000343246

    UniGene: Hs.67397