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  4. Recombinant Human Homeobox protein Hox-B9 (HOXB9)

Recombinant Human Homeobox protein Hox-B9 (HOXB9)

  • 中文名称：
    人HOXB9重组蛋白
  • 货号：
    CSB-YP010669HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HOXB9重组蛋白
  • 货号：
    CSB-EP010669HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HOXB9重组蛋白
  • 货号：
    CSB-EP010669HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HOXB9重组蛋白
  • 货号：
    CSB-BP010669HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HOXB9重组蛋白
  • 货号：
    CSB-MP010669HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOXB9
  • Uniprot No.：
  • 别名：
    Homeo box 2E ; Homeo box B9 ; Homeobox B9; Homeobox protein Hox B9; Homeobox protein Hox-2.5; Homeobox protein Hox-2E; Homeobox protein Hox-B9; Hox 2.5; Hox 2E; HOX2; HOX2E; Hoxb9; HXB9_HUMAN; OTTHUMP00000216946; OTTHUMP00000243325
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-250
  • 氨基酸序列
    MSISGTLSSY YVDSIISHES EDAPPAKFPS GQYASSRQPG HAEHLEFPSC SFQPKAPVFG ASWAPLSPHA SGSLPSVYHP YIQPQGVPPA ESRYLRTWLE PAPRGEAAPG QGQAAVKAEP LLGAPGELLK QGTPEYSLET SAGREAVLSN QRPGYGDNKI CEGSEDKERP DQTNPSANWL HARSSRKKRC PYTKYQTLEL EKEFLFNMYL TRDRRHEVAR LLNLSERQVK IWFQNRRMKM KKMNKEQGKE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. These findings integrate the complexity of numerous mechanisms of anti-VEGF resistance into the single transcription factor HOXB9. Silencing HOXB9 could be a promising approach to modulate this resistance. Our results candidate HOXB9 as predictive biomarker for selecting colorectal cancer patients for antiangiogenic therapy PMID: 28298545
    2. Study demonstrated that HOXB9 may facilitate hypertrophic scar formation via activating the mitogenactivated protein kinase signaling pathway. PMID: 28656236
    3. this study revealed that HOXB9, HOXB13, and HOXD13 were upregulated and may play important roles in laryngeal squamous cell carcinoma (LSCC). Moreover, HOXB9 may serve as a novel marker of poor prognosis and a potential therapeutic target in LSCC patients. PMID: 28808656
    4. These findings suggest that hoxb7 and hoxb9 proteins might play a role in salivary gland tumourigenesis, but in contrast to the reported for other human cancers, they were not significant prognostic determinants in the sample studied PMID: 26991799
    5. HOXB9 interfered the activities of NF-kappaB, nuclear factor of activated T-cells (NFAT) and AP-1 but not retinoic acid receptor-related orphan receptor, resulting in attenuation of the production of selective cytokines in activated T cells. PMID: 26926958
    6. AcK27-HOXB9 suppresses the transcription of its target gene Jumonji domain-containing protein 6 (JMJD6) by direct occupying the promoter of JMJD6 gene. PMID: 27613418
    7. High expression of HoxB9 is a prognostic marker for lung adenocarcinoma patients. PMID: 25324169
    8. We also found that FAT10 may act its oncogenic functions through regulating HOXB9. Collectively, the results suggested that FAT10 may be a novel therapeutic target for osteosarcoma patients PMID: 27279480
    9. the results of the present study suggested that HOXB9 is a tumor suppressor in gastric carcinoma, and its activity was controlled by different regulatory mechanisms such as the hexapeptide motif as a "brake" in this case PMID: 26536658
    10. Expression of GalNAc-T14 or HOXB9 was strongly correlated with reduced recurrence-free survival in lung adenocarcinomas. PMID: 26544896
    11. Knock-down of HOXB9 expression decreased migration, invasion and proliferation but did not alter adhesion. PMID: 25860510
    12. HOXB9 promotes epithelial-to-mesenchymal transition via TGF-beta1 pathway in hepatocellular carcinoma cells. PMID: 25081022
    13. Identification of the transcription factor binding site of the HOXB9 promoter region suggests that E2F1 is a direct regulator of HOXB9 expression in breast cancer. PMID: 25136922
    14. Low HOXB9 expression promotes pancreatic ductal adenocarcinoma progression. PMID: 25724625
    15. HOXB9 promoted colon adenocarcinoma differentiation. PMID: 25025961
    16. HOXB9 overexpression increased the tumorigenicity of glioma cells in vivo. Moreover, the activation of transforming growth factor-beta1 contributed to HOXB9-induced oncogenic activities. PMID: 24582746
    17. Data show that the HOXB9 overexpression group had significantly shorter overall survival time than the HOXB9 downexpression group. PMID: 24462859
    18. rs2303486 may be associated with severity of developmental dysplaasia of the hip in Chinese Han females. PMID: 24600698
    19. HOXB9 is down-regulation in gastric carcinoma and may be a novel prognostic marker for poorer clinical outcome for patients with gastric carcinoma. PMID: 23332081
    20. The expression of HOXB9, its relationship to clinical factors in breast cancer and efficacy as a prognostic factor were discussed. PMID: 23350386
    21. HOXB9 is overexpressed in breast cancer tissue. PMID: 22863320
    22. reduced expression of CD56 is associated with homeobox B9 in papillary thyroid carcinomas. Further, silencing of homeobox B9 is more common in older age and is linked to extrathyroidal extension and advanced pathologic stage of papillary thyroid carcinoma PMID: 22225776
    23. HOXB9 overexpression promoting tumor cell proliferation and angiogenesis is associated with breast cancer. PMID: 22396001
    24. The effect of HOXB9 on the response to ionizing radiation requires the baseline ATM activity before irradiation and epithelial-to-mesenchymal transition induced by TGF-beta. PMID: 21930940
    25. HOXB9 is an E2-responsive gene and ERs coordinate with MLL1 and MLL3 in E2-mediated transcriptional regulation of HOXB9. PMID: 21428455
    26. deregulated expression of HOXB9 contributes to breast cancer progression and lung metastasis by inducing several growth factors that alter tumor-specific cell fates and the tumor stromal microenvironment PMID: 20080567
    27. ERK5 probably mediates HOXB9 expression by repressing BMI1 in Hodgkin lymphoma cell lines PMID: 17148583
    28. Two WNT target genes, LEF1 and HOXB9, are identified as promoters of lung adenocarcinoma metastasis and mediators of chemotactic invasion and colony outgrowth. PMID: 19576624

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Abd-B homeobox family
  • 数据库链接：

    HGNC: 5120

    OMIM: 142964

    KEGG: hsa:3219

    STRING: 9606.ENSP00000309439

    UniGene: Hs.463350