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  4. Recombinant Human Homeobox protein MSX-2 (MSX2)

Recombinant Human Homeobox protein MSX-2 (MSX2)

  • 货号：
    CSB-YP015069HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015069HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015069HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015069HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015069HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    MSX2
  • Uniprot No.：
  • 别名：
    CRS 2; CRS2; FPP; Homeo box msh like 2; Homeobox protein Hox-8; Homeobox protein MSX 2; Homeobox protein MSX-2; Homeobox protein MSX2; Hox 8; Hox8; MSH; Msh homeo box 2; Msh homeo box homolog; Msh homeo box homolog 2; Msh homeobox 2; Msh homeobox homolog 2; Msx 2; MSX2; MSX2_HUMAN; Parietal foramina 1; PFM 1; PFM; PFM1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-267
  • 氨基酸序列
    MASPSKGNDL FSPDEEGPAV VAGPGPGPGG AEGAAEERRV KVSSLPFSVE ALMSDKKPPK EASPLPAESA SAGATLRPLL LSGHGAREAH SPGPLVKPFE TASVKSENSE DGAAWMQEPG RYSPPPRHMS PTTCTLRKHK TNRKPRTPFT TSQLLALERK FRQKQYLSIA ERAEFSSSLN LTETQVKIWF QNRRAKAKRL QEAELEKLKM AAKPMLPSSF SLPFPISSPL QAASIYGASY PFHRPVLPIP PVGLYATPVG YGMYHLS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
  • 基因功能参考文献：
    1. MSX2 might be a new drug resistance related gene in pancreatic cancer cells by up-regulation of MRP2 expression. PMID: 29860758
    2. MSX2 played a crucial role in the progression of colorectal cancer and may be a potential novel prognostic factor PMID: 28286778
    3. MSX2 protein expression is downregulated in placental villi from Pre-Eclampsia. PMID: 27088357
    4. The MSX2 destabilizes the pluripotency circuitry through direct binding to the SOX2 promoter, while MSX2 controls mesendoderm lineage commitment by simultaneous suppression of SOX2 and induction of NODAL expression. PMID: 26427715
    5. This is the first report of an eye development defect due to an increase in the MSX2 copy number in a human being. PMID: 24666290
    6. SLUG and MSX2, transcription factors involved in epithelial-mesenchymal transitions, essential features of gastrulation in development and tumor progression, are important mediators of BMP4-induced differentiation in human embryonic stem cells. PMID: 24549638
    7. These data confirm that missense mutations altering the proline at codon 148 of MSX2 cause dominantly inherited craniosynostosis. PMID: 23949913
    8. PKC signaling modulates osteoblast differentiation, at least in part, through the regulation of Msx2. PMID: 22633971
    9. Msx2 and topo II-alpha may play an important role in the occurrence and development of sinonasal inverted papilloma. PMID: 22730815
    10. The pathogenic effect of the microduplications can best be explained by a misregulation of spatiotemporal MSX2 expression patterns in cleidocranial dysplasia. PMID: 22717651
    11. Cyclic tensile stress may induce differentiation of periodontal ligament stem cells towards mineralized tissue cells by promoting Dlx5 mRNA expression and decreasing Msx2 expression. PMID: 22332551
    12. The detailed regulatory mechanism of ABCG2 expression by MSX2 in pancreatic cancer cells was investigated. PMID: 21465479
    13. activation of RAGE not only inhibits myocardin-dependent SMC gene expression, but also induces osteogenic differentiation of vascular SMC through Notch/Msx2 induction PMID: 21512281
    14. findings indicate MSX2 is a direct downstream transcriptional target of beta-catenin/TCF and has a key contributing role in the cancer phenotype of OEAs carrying WNT/beta-catenin pathway defects PMID: 21499300
    15. MSX2 may be an important regulator of melanoma cell invasion and survival. Cytoplasmic expression of the protein was identified as biomarker for good prognosis in malignant melanoma. PMID: 21730974
    16. Notch1 intracellular domain.RBPJk complex enhances the BMP2-induced Msx2 gene expression by cooperating with Smad1 and suggest that Notch signaling makes vascular SMC responsive to BMP2 and promotes vascular calcification. PMID: 21471203
    17. Maternal Msx2 C386T gene polymorphisms were associated with fetal neural tube defects in Han Chinese women in Shanxi Province. PMID: 21362336
    18. The sensitivity of MSX2 expression level for cholangiocarcinoma was much higher than that of cytology. PMID: 21498730
    19. Data suggest that increased Msx2 expression results in improved outcome for breast cancer patients, possibly by increasing the likelihood of tumour cell death by apoptosis. PMID: 20682066
    20. Data reveal a selective upregulation of MSX2 expression in human fetal ovary in response to BMP4, suggesting this gene may act as a downstream effector of BMP-induced apoptosis in the ovary. PMID: 20506112
    21. MSX2 plays a pivotal role in the development of intraductal papillary mucinous neoplasm (IPMN) through growth stimulation of tumor cells, and its expression was identified as an independent predictive factor for malignancy of benign branch duct-IPMN PMID: 20107842
    22. TNF-alpha directly induces MSX2 expression through the NF-kappaB pathway, which in turn induces expression of alkaline phosphatase, a key molecule in mineralization, in VSMCs. PMID: 20004646
    23. MSX2 activates NOTCH3-signaling in leukemic T-cells. PMID: 19835636
    24. Bone sialoprotein expression is additionally regulated by the homeodomain factor Msx2, another regulator of osteoblast-associated genes. PMID: 12750290
    25. Results suggest that Msx2 plays a central role in preventing ligaments and tendons from mineralizing, in part by suppressing Runx2/Osf2 transcriptional activity. PMID: 15060165
    26. Results suggest that MSX2 exerts repressive effects on the gemcitabine-induced apoptotic pathway in pancreatic cancer cells. PMID: 16425399
    27. In dental follicle cells, gene expression of runx2, DLX-5, and MSX-2 was unaffected during osteogenic differentiation in vitro. PMID: 16467978
    28. This provides genetic evidence that Twist1, Msx2 and Efna4 function together in boundary formation and the pathogenesis of coronal synostosis. PMID: 16540516
    29. MSX2 homeobox mutation in a family with foramina parietalia permagna, headache, and vascular anomaly. PMID: 16642368
    30. vascular Bmp Msx2 Wnt signaling and oxidative stress have roles in arterial calcification [review] PMID: 18056036
    31. Msx2 expression may represent a useful prognostic marker in inverted papilloma. PMID: 18187185
    32. MSX2 polymorphisms are associated with ankylosing spondylitis in Japanese but not in Taiwanese population. PMID: 18299954
    33. These data indicate that MSX2 plays a crucial role in pancreatic cancer development by inducing changes consistent with epithelial to mesenchymal transition through enhanced expression of Twist 1. PMID: 18349132
    34. the primary function of MSX2 in suture closure is the induction of cell proliferation and suture maintenance, and the mutation results in an increased susceptibility of both wild type and mutant MSX2 to proteasomal degradation PMID: 18786927
    35. In this review, Msx2 is shown to function as a transcriptional enhancer downstream of fibroblast growth factor 2 in calvarial pre-osteoblastic cells. PMID: 19147956
    36. These results imply a new mechanism for osteogenic differentiation of vascular smooth muscle cellss in which Notch/RBP-Jk signaling directly induces Msx2(msh homeobox 2) gene expression . PMID: 19407244

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  • 相关疾病：
    Parietal foramina 1 (PFM1); Parietal foramina with cleidocranial dysplasia (PFMCCD); Craniosynostosis 2 (CRS2)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Msh homeobox family
  • 数据库链接：

    HGNC: 7392

    OMIM: 123101

    KEGG: hsa:4488

    STRING: 9606.ENSP00000239243

    UniGene: Hs.89404