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  4. Recombinant Human Homeobox protein PKNOX1 (PKNOX1)

Recombinant Human Homeobox protein PKNOX1 (PKNOX1)

  • 中文名称：
    人PKNOX1重组蛋白
  • 货号：
    CSB-YP018077HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人PKNOX1重组蛋白
  • 货号：
    CSB-EP018077HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人PKNOX1重组蛋白
  • 货号：
    CSB-EP018077HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人PKNOX1重组蛋白
  • 货号：
    CSB-BP018077HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人PKNOX1重组蛋白
  • 货号：
    CSB-MP018077HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    PKNOX1
  • Uniprot No.：
  • 别名：
    Homeobox protein PKNOX1; Homeobox protein PREP-1; Human homeobox containing protein ; Pbx regulating protein 1; PBX/knotted 1 homeobox 1; PBX/knotted homeobox 1; Pknox1; PKNX1_HUMAN; pkonx1c; PREP1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-436
  • 氨基酸序列
    MMATQTLSID SYQDGQQMQV VTELKTEQDP NCSEPDAEGV SPPPVESQTP MDVDKQAIYR HPLFPLLALL FEKCEQSTQG SEGTTSASFD VDIENFVRKQ EKEGKPFFCE DPETDNLMVK AIQVLRIHLL ELEKVNELCK DFCSRYIACL KTKMNSETLL SGEPGSPYSP VQSQQIQSAI TGTISPQGIV VPASALQQGN VAMATVAGGT VYQPVTVVTP QGQVVTQTLS PGTIRIQNSQ LQLQLNQDLS ILHQDDGSSK NKRGVLPKHA TNVMRSWLFQ HIGHPYPTED EKKQIAAQTN LTLLQVNNWF INARRRILQP MLDSSCSETP KTKKKTAQNR PVQRFWPDSI ASGVAQPPPS ELTMSEGAVV TITTPVNMNV DSLQSLSSDG ATLAVQQVMM AGQSEDESVD STEEDAGALA PAHISGLVLE NSDSLQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Activates transcription in the presence of PBX1A and HOXA1.
  • 基因功能参考文献：
    1. PREP1 modulates the cellular sensitivity to TGF-beta by inducing the small mothers against decapentaplegic homolog 3 (SMAD3) nuclear translocation. PMID: 25157139
    2. High levels of MEIS1 and PREP1, and low levels of PBX4 expression were founded in samples of patients with ALL. PMID: 22185299
    3. Single nucleotide polymorphism in gene encoding transcription factor Prep1 is associated with HIV-1-associated dementia PMID: 22347417
    4. The tumor suppressor role of Prep1 is associated with the maintenance of genomic stability. PMID: 21715654
    5. analysis of the regulatory region of the zebrafish Prep1.1 gene and the promoter of human PREP1 PMID: 21203543
    6. Immunohistochemistry on tissue micrroarrays (TMA) generated from three distinct human cohorts comprising a total of some 1000 human tumors revealed that 70% of the tumors express no or extremely low levels of Prep1, unlike normal tissues. PMID: 20106730
    7. PKNOX1 gene-dosage imbalance is associated with overexpression of FABP7 in Down syndrome fetal brains. PMID: 12771203
    8. PREP-1 has a role in F9 teratocarcinoma cells: it causes an increase of PBX-2 by preventing its degradation PMID: 12871956

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/MEIS homeobox family
  • 组织特异性：
    Ubiquitous. Isoform 2 is expressed in all examined tissues except in bone marrow.
  • 数据库链接：

    HGNC: 9022

    OMIM: 602100

    KEGG: hsa:5316

    STRING: 9606.ENSP00000291547

    UniGene: Hs.431043