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  4. Recombinant Human Homeobox protein TGIF2 (TGIF2)

Recombinant Human Homeobox protein TGIF2 (TGIF2)

  • 中文名称：
    人TGIF2重组蛋白
  • 货号：
    CSB-YP884421HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人TGIF2重组蛋白
  • 货号：
    CSB-EP884421HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人TGIF2重组蛋白
  • 货号：
    CSB-EP884421HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人TGIF2重组蛋白
  • 货号：
    CSB-BP884421HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人TGIF2重组蛋白
  • 货号：
    CSB-MP884421HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    5' TG 3' interacting factor 2; 5''-TG-3''-interacting factor 2; Homeobox protein TGIF2; TGF (beta) induced transcription factor 2; TGF beta induced factor 2; TGF-beta-induced transcription factor 2; TGFB induced factor 2; TGFB-induced factor 2; Tgif2; TGIF2_HUMAN; Transforming growth factor beta induced factor 2
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-237
  • 氨基酸序列
    SDSDLGEDE GLLSLAGKRK RRGNLPKESV KILRDWLYLH RYNAYPSEQE KLSLSGQTNL SVLQICNWFI NARRRLLPDM LRKDGKDPNQ FTISRRGGKA SDVALPRGSS PSVLAVSVPA PTNVLSLSVC SMPLHSGQGE KPAAPFPRGE LESPKPLVTP GSTLTLLTRA EAGSPTGGLF NTPPPTPPEQ DKEDFSSFQL LVEVALQRAA EMELQKQQDP SLPLLHTPIP LVSENPQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional repressor, which probably repress transcription by binding directly the 5'-CTGTCAA-3' DNA sequence or by interacting with TGF-beta activated SMAD proteins. Probably represses transcription via the recruitment of histone deacetylase proteins.
  • 基因功能参考文献：
    1. Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. PMID: 27956704
    2. s suggest that miR-148a inhibits OC cell proliferation and invasion partly through inhibition of TGFI2. Therefore, this study highlights the importance of the miR-148a/TGFI2 axis in the malignant progression of OC. PMID: 27712592
    3. Data show that TGFB-induced factor 2 protein (TGIF2) is involved in microRNA miR-541-3p-regulated cell proliferation, invasion, migration, as well as cell cycle of non-small lung cancer (NSCLC) cells. PMID: 27448300
    4. expression of miR-148a was regulated by DNA methylation and targeted by TGIF2. Its methylation may be a potential prognostic indicator in skin cancer PMID: 26638007
    5. miR-34a could inhibit tumor invasion and metastasis in gastric cancer by targeting Tgif2 PMID: 26464633
    6. Corneal fibroblasts demonstrate the expression of TGIF1 and TGIF2 transcription factors. These transcriptional repressors are critical, at least partially, in mediating the antifibrotic effect of vorinostat in the cornea. PMID: 26330748
    7. Shows that the homologous mouse Tgif2 gene is necessary for gastrulation. PMID: 20040491

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  • 亚细胞定位：
    Nucleus. Note=Excluded from nucleoli.
  • 蛋白家族：
    TALE/TGIF homeobox family
  • 组织特异性：
    Widely expressed. Highly expressed in heart, kidney and testis. Weakly expressed in brain and prostate.
  • 数据库链接：

    HGNC: 15764

    OMIM: 607294

    KEGG: hsa:60436

    STRING: 9606.ENSP00000362979

    UniGene: Hs.632264