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  4. Recombinant Human Homeobox protein engrailed-1 (EN1)

Recombinant Human Homeobox protein engrailed-1 (EN1)

  • 中文名称：
    人EN1重组蛋白
  • 货号：
    CSB-YP007659HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人EN1重组蛋白
  • 货号：
    CSB-EP007659HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人EN1重组蛋白
  • 货号：
    CSB-EP007659HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人EN1重组蛋白
  • 货号：
    CSB-BP007659HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人EN1重组蛋白
  • 货号：
    CSB-MP007659HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    EN1
  • Uniprot No.：
  • 别名：
    En 1; EN1; Engrailed 1; Engrailed; Engrailed homeobox 1; Engrailed homolog 1; HME1_HUMAN; Homeobox protein en-1; Homeobox protein engrailed 1; Homeobox protein engrailed-1; Hu-En-1; Mo-en.1; OTTHUMP00000162091
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-392
  • 氨基酸序列
    MEEQQPEPKS QRDSALGAAA AATPGGLSLS LSPGASGSSG SGSDGDSVPV SPQPAPPSPP AAPCLPPLAH HPHLPPHPPP PPPQHLAAPA HQPQPAAQLH RTTNFFIDNI LRPDFGCKKE QPPPQLLVAA AARGGAGGGG RVERDRGQTA AGRDPVHPLG TRAPGAASLL CAPDANCGPP DGSQPAAAGA GASKAGNPAA AAAAAAAAVA AAAAAAAAKP SDTGGGGSGG GAGSPGAQGT KYPEHGNPAI LLMGSANGGP VVKTDSQQPL VWPAWVYCTR YSDRPSSGPR TRKLKKKKNE KEDKRPRTAF TAEQLQRLKA EFQANRYITE QRRQTLAQEL SLNESQIKIW FQNKRAKIKK ATGIKNGLAL HLMAQGLYNH STTTVQDKDE SE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Engrailed homeobox 1 was expressed specifically in normal eccrine glands and was expressed in most of the tumour cells of sweat gland neoplasms with eccrine gland differentiation. PMID: 29436004
    2. our finding suggested that the EN1 rs4144782 might contribute to the susceptibility of knee OA. PMID: 28430581
    3. FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform PMID: 26762209
    4. low-frequency non-coding variant near a novel locus, EN1, with an effect on bone mineral density--which was also associated with a decreased risk of fracture PMID: 26367794
    5. EN1 is an activator of intrinsic inflammatory pathways associated with prosurvival in basal-like breast cancer. PMID: 24141779
    6. The current review describes the role of two such factors, Nurr1 and engrailed, in differentiation, maturation, and in normal physiological functions including acquisition of neurotransmitter identity. PMID: 24685177
    7. EN1 is a biologic predictor of poor prognosis in patients with salivary adenoid cystic carcinoma. PMID: 21800291
    8. Homeobox protein engrailed-1 protein regulates transcription of the utrophin gene. PMID: 21672318
    9. EN1 might be a negative regulatory factor for UTROPHIN. PMID: 21482524
    10. The result of this study found a strong association between the EN1 rs1438852 polymorphism and Parkinson's disease. PMID: 19345444
    11. En-1 exerts its repressive effect by a mechanism negatively controlling the level of beta-catenin. PMID: 16571670
    12. Single nucleotide polymorphisms genotyped in the EN1 gene were associated with schizophrenia symptoms PMID: 18698228
    13. Epigenetic suppression along 2q14.2 is common to most colorectal cancers and the presence of a methylated EN1 CpG island in stool DNA might be used as biomarker of neoplastic disease. PMID: 19384295
    14. Genetic variation in human engrailed 1 may influence antipsychotic response in schizophrenia. PMID: 18698228

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Engrailed homeobox family
  • 数据库链接：

    HGNC: 3342

    OMIM: 131290

    KEGG: hsa:2019

    STRING: 9606.ENSP00000295206

    UniGene: Hs.271977