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  4. Recombinant Human Homeodomain-only protein (HOPX)

Recombinant Human Homeodomain-only protein (HOPX)

  • 中文名称：
    人HOPX重组蛋白
  • 货号：
    CSB-YP859411HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HOPX重组蛋白
  • 货号：
    CSB-EP859411HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HOPX重组蛋白
  • 货号：
    CSB-EP859411HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HOPX重组蛋白
  • 货号：
    CSB-BP859411HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HOPX重组蛋白
  • 货号：
    CSB-MP859411HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HOPX
  • Uniprot No.：
  • 别名：
    CAMEO; heart odd homeobox 1 protein; HOD; Homeodomain-only protein; HOP; HOP homeobox; HOP_HUMAN; HOPX; LAGY; Lung cancer-associated Y protein; NECC1; Not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; OB1; odd homeobox 1 protein; Odd homeobox protein 1; OTTHUMP00000158970; SMAP31; TOTO
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-73
  • 氨基酸序列
    MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR SEGLPSECRS VTD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding.
  • 基因功能参考文献：
    1. Data suggest that HOP homeobox HOPX (HOPX) acts as a tumour suppressor via the epigenetic regulation of snail family transcription factors (SNAIL) transcription and a prognostic biomarker for nasopharyngeal carcinoma (NPC) metastasis and therapeutic target for NPC treatment. PMID: 28146149
    2. HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis PMID: 27934959
    3. The association between the MEEVD C-terminal peptide from the heat shock protein 90 (Hsp90) and tetratricopeptide repeat A (TPR2A) domain of the heat shock organizing protein (Hop) is a useful prototype to study the fundamental molecular details about the Hop-Hsp90 interaction. Observed are conformational changes of the peptide and the protein receptor induced by binding. The binding free energy is 8.4 kcal/mol. PMID: 28723223
    4. HOPX is functionally regulated by SCL in hematoendothelial differentiation of mesoderm progenitor cells. PMID: 28813672
    5. HOPX is a distinctive homeobox gene with characteristic clinical and biological implications and its expression is a powerful predictor of prognosis in AML patients. PMID: 28341738
    6. HOPX has a role in the pathogenesis of skin cancers and skin diseases. PMID: 27017330
    7. these data indicate that the disruption of the PrP(C)-HOP complex could be a potential therapeutic target for modulating the migratory and invasive cellular properties that lead to metastatic Colorectal cancer (CRC). PMID: 27112151
    8. HOPX promoter methylation is not only frequent and cancer-specific but also associated with aggressive phenotype in breast cancer. PMID: 27756570
    9. Computational results identified HOPX gene as a new potential driver for ovarian carcinogenesis. PMID: 27287041
    10. The results suggest that HOPX may contribute to pathogenesis or manifestation of hypertrophic cardiomyopathy as a modifier gene. PMID: 25036325
    11. Data show that binding of heat shock proteins Hsp70 and Hsp90 requires prior binding of Hop protein to Hsp90. PMID: 26286954
    12. HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer. PMID: 25345926
    13. GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype. PMID: 23707782
    14. HOPX-beta promoter methylation is a frequent and cancer-specific event in CRC progression. PMID: 22904674
    15. Knockdown of Hop caused a decrease in the level of RhoC GTPase, and significantly inhibited pseudopodia formation in Hs578T cells. Our data suggest that Hop regulates directional cell migration by multiple unknown mechanisms. PMID: 23036489
    16. HOPX/Hopx expression is reduced in multiple examples of human and murine cardiac hypertrophy and failure. PMID: 21382376
    17. results identify distinct functions for the Hop cochaperone, revealing an asymmetric mechanism for Hsp90 regulation and client loading PMID: 21700222
    18. HOP is a novel modulator of late terminal differentiation in keratinocytes PMID: 21256618
    19. Hopx regulates the expression of genes involved in regulation of apoptosis and survival and makes them refractory to Fas-induced apoptosis. PMID: 21061432
    20. HOPX-beta promoter methylation is a frequent and cancer-specific event in gastric cancer PMID: 20228841
    21. HOPX is modulated by cell differentiation in human keratinocytes and this might contribute to homeostasis of keratinocytes by controlling differentiation-dependent genes. PMID: 20226564
    22. Loss of NECC1 expression is involved in malignant conversion of placental trophoblasts. PMID: 12573257
    23. Gene mapping locates LAGY on chromosome 4q11-13.1. In 72 primary lung tumors, this gene was significantly down-regulated compared to 9 normal lung tissue samples. PMID: 12759545
    24. One role of Hop is to modify the expression of cardiac-specific genes and thereby finely regulate heart development. PMID: 14522464
    25. Decrease in homeodomain-only protein is associated with hypopharyngeal carcinoma PMID: 15213722
    26. SMAP31 expression is elevated in 4 of 6 papillary thyroid tumor samples compared to 4 normal thyroid controls. PMID: 15307938
    27. loss of NECC1 expression is involved in malignant conversion of placental trophoblasts PMID: 15457851
    28. Our results demonstrate that the homeodomain fold has been co-opted during evolution for functions other than sequence-specific DNA binding and suggest that HOP functions as an adaptor protein to mediate transcriptional repression. PMID: 16939210
    29. The data indicate that signaling induced by hop/STI-1 depends on endocytosis PMID: 17498662
    30. Gradual induction of HOP/NECC1 in response to differentiation stimuli may result in the decision to differentiate into a particular type of trophoblastic cell lineage and result in non-lethal defects PMID: 17576768
    31. HOP is a putative tumor suppressor gene that harbors tumor inhibitory activity. PMID: 18234960
    32. HOP may work as a tumor suppressor in a subset of glioblastomas; HOP function thus appears to be critical in the adult brain in a region of continued plasticity, and its deregulation may contribute to disease PMID: 18507846
    33. transcriptional silencing of HOPX results from hypermethylation of the HOPpromoter, which leads to human uterine endometrial cancers (HEC) development. PMID: 19173292

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 组织特异性：
    Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma an
  • 数据库链接：

    HGNC: 24961

    OMIM: 607275

    KEGG: hsa:84525

    STRING: 9606.ENSP00000450527

    UniGene: Hs.619396