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  4. Recombinant Human Huntingtin-interacting protein K (HYPK)

Recombinant Human Huntingtin-interacting protein K (HYPK)

  • 中文名称：
    人HYPK重组蛋白
  • 货号：
    CSB-YP885751HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人HYPK重组蛋白
  • 货号：
    CSB-EP885751HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人HYPK重组蛋白
  • 货号：
    CSB-EP885751HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人HYPK重组蛋白
  • 货号：
    CSB-BP885751HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人HYPK重组蛋白
  • 货号：
    CSB-MP885751HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HYPK
  • Uniprot No.：
  • 别名：
    Huntingtin yeast partner K; Huntingtin-interacting protein K; HYPK; HYPK_HUMAN
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-129
  • 氨基酸序列
    MRRRGEIDMA TEGDVELELE TETSGPERPP EKPRKHDSGA ADLERVTDYA EEKEIQSSNL ETAMSVIGDR RSREQKAKQE REKELAKVTI KKEDLELIMT EMEISRAAAE RSLREHMGNV VEALIALTN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of several N-terminal acetyltransferase complexes. Inhibits the N-terminal acetylation activity of the N-terminal acetyltransferase NAA10-NAA15 complex (also called the NatA complex). Has chaperone-like activity preventing polyglutamine (polyQ) aggregation of HTT in neuronal cells probably while associated with the NatA complex. May play a role in the NatA complex-mediated N-terminal acetylation of PCNP.
  • 基因功能参考文献：
    1. In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity PMID: 28585574
    2. study provides evidence of the existence of disordered nanostructure in HYPK protein that mechanistically plays a decisive role in preventing both self and non-self protein aggregation. PMID: 29381348
    3. HYPK can act as negative regulator of heat shock response by repressing transcriptional activity of HSF1. PMID: 27017930
    4. Results show that HYPK, possibly with its interacting partners, induces autophagy. results further confirm that HYPK could also be involved in clearing mutant HTT aggregates by augmenting autophagy pathway. PMID: 27067261
    5. By virtue of its flexibility and nascent peptide binding activity, HYPK may play an important role in assisting protein (re)folding. PMID: 25116620
    6. specific interaction of HYPK with HTT-N17 is crucial for the chaperone activity of HYPK PMID: 25446099
    7. Chaperone-like protein HYPK is induced by cellular stress and is under transcriptional regulation by HSF1. PMID: 24465598
    8. maintenance of HYPK expression by HSF1 is necessary for the survival of cells under thermal stress conditions PMID: 24361604
    9. HYPK has roles in regulating cell growth, cell cycle, unfolded protein response and cell death PMID: 23272104
    10. The present study, has confirmed, by confocal microscopy and immunoprecipitation, that HYPK interacts with the N-terminal of Htt. PMID: 17947297

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 数据库链接：

    HGNC: 18418

    OMIM: 612784

    KEGG: hsa:25764

    STRING: 9606.ENSP00000384474

    UniGene: Hs.730672