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  4. Recombinant Human Hyaluronan mediated motility receptor (HMMR)

Recombinant Human Hyaluronan mediated motility receptor (HMMR)

  • 货号：
    CSB-YP010582HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP010582HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP010582HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP010582HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP010582HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CD168; CD168 antigen; HMMR; HMMR_HUMAN; Hyaluronan mediated motility receptor; Hyaluronan-mediated motility receptor (RHAMM); IHABP; Intracellular hyaluronic acid-binding protein; MGC119494; MGC119495; OTTHUMP00000196920; Receptor for hyaluronan-mediated motility; RHAMM
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-724
  • 氨基酸序列
    MSFPKAPLKR FNDPSGCAPS PGAYDVKTLE VLKGPVSFQK SQRFKQQKES KQNLNVDKDT TLPASARKVK SSESKESQKN DKDLKILEKE IRVLLQERGA QDRRIQDLET ELEKMEARLN AALREKTSLS ANNATLEKQL IELTRTNELL KSKFSENGNQ KNLRILSLEL MKLRNKRETK MRGMMAKQEG MEMKLQVTQR SLEESQGKIA QLEGKLVSIE KEKIDEKSET EKLLEYIEEI SCASDQVEKY KLDIAQLEEN LKEKNDEILS LKQSLEENIV ILSKQVEDLN VKCQLLEKEK EDHVNRNREH NENLNAEMQN LKQKFILEQQ EREKLQQKEL QIDSLLQQEK ELSSSLHQKL CSFQEEMVKE KNLFEEELKQ TLDELDKLQQ KEEQAERLVK QLEEEAKSRA EELKLLEEKL KGKEAELEKS SAAHTQATLL LQEKYDSMVQ SLEDVTAQFE SYKALTASEI EDLKLENSSL QEKAAKAGKN AEDVQHQILA TESSNQEYVR MLLDLQTKSA LKETEIKEIT VSFLQKITDL QNQLKQQEED FRKQLEDEEG RKAEKENTTA ELTEEINKWR LLYEELYNKT KPFQLQLDAF EVEKQALLNE HGAAQEQLNK IRDSYAKLLG HQNLKQKIKH VVKLKDENSQ LKSEVSKLRC QLAKKKQSET KLQEELNKVL GIKHFDPSKA FHHESKENFA LKTPLKEGNT NCYRAPMECQ ESWK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for hyaluronic acid (HA). Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity. May act as a regulator of adipogenisis.
  • 基因功能参考文献：
    1. A mechanism of sense-antisense interference between HMMR and HMMR-AS1 in GBM. PMID: 29574252
    2. This pilot study shows, for the first time, that RHAMM may contribute to ovarian cancer disease and could potentially be used as a prognostic marker. PMID: 28954627
    3. The ability to enhance cell polarity through the application of this dielectrophoretic (DEP) electromagnetic field (EMF) force may offer another way to stabilize HMMR and differentially modulate its expression in cancerous and noncancerous cells. PMID: 28595038
    4. we found that RHAMM-specific T cells are present at vaccination sites in AML patients. Our findings implicate that we and others who are using classical mo-DCs for cancer immunotherapy are already vaccinating against RHAMM. PMID: 27659531
    5. RHAMM, most likely RHAMMv3 (RHAMMB), can serve as a prognostic factor for lung adenocarcinomas and a potential therapeutic target in non-small cell lung carcinoma to inhibit tumor migration PMID: 27220886
    6. Data show that receptor of hyaluronan-mediated motility (RHAMM) mRNA expression in breast cancer biopsies is inversely correlated with tumor grade and overall survival. PMID: 26870892
    7. spindle-associated RHAMM as an intrinsic regulator of male germ cell fate and as a gatekeeper preventing initiation of testicular germ cell tumors (TGCT). PMID: 27543603
    8. Overexpression of the hyaluronan receptor HMMR in primary LUAD was associated with an inflammatory molecular signature and poor prognosis. Attenuating HMMR in LUAD cells diminished their ability to initiate lung tumors and distant metastases. PMID: 28196904
    9. The present study suggests that RHAMM is a novel beta-catenin intracellular binding partner, protecting beta-catenin from degradation and supporting the nuclear translocation of this key cellular mediator PMID: 26825774
    10. RHAMM expression identifies an aggressive subpopulation of tumor budding cells and is an independent adverse prognostic factor for colorectal cancer patients. PMID: 26351067
    11. a causative link between altered function of AURKA-HMMR-TPX2-TUBG1 and breast carcinogenesis in BRCA1/2 mutation carriers PMID: 25830658
    12. Identify RHAMM as a critical regulator of TPX2 location/ Aurora kinase A signaling and suggest that RHAMM ensures bipolar spindle assembly and mitotic progression through the integration of biochemical and structural pathways. PMID: 24875404
    13. In ocular TM cells, our data suggests that the most important determinant of HA cable formation appears to be the ratio of HA chains produced by the different HAS genes. PMID: 26247678
    14. RHAMM might be a promising marker to identify early stage (nodal negative) patients at risk for dismal survival, who may benefit from specific adjuvant therapies. PMID: 25731190
    15. analysis of the role of growth factors in Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis [review] PMID: 25081535
    16. Case Report: identify patient with cervical cancer expressing three HMMR mRNA variants. PMID: 24966934
    17. RHAMM may be implicated in severe ocular surface inflammation affecting the upper tarsal conjunctiva. PMID: 24916930
    18. stimulation of the E2F1-RHAMM axis in aggressive cancer cells is of high clinical significance PMID: 25042645
    19. HMMR overexpression promotes GSC self-renewal. PMID: 24710409
    20. RHAMM plays a crucial role in mediating progression of muscle-invasive bladder cancer and recommends RHAMM for further evaluation as a prognostic marker or therapeutic target in bladder cancer therapy. PMID: 24069434
    21. RHAMM transcription is regulated via YAP in a pathway involving mevalonate and Hippo that modulates breast cancer cell motility PMID: 24367099
    22. Suggest that detection of upregulated RHAMM expression in an ossifying fibroma assists with differential diagnosis and has a key role in elucidation of its pathophysiology. PMID: 23382057
    23. Data indicate that the sensitivity of cell-lines with amplification of AURKA depends upon the activity of the kinase, which correlates with the expression of the regulatory gene products TPX2 and HMMR/RHAMM. PMID: 23328114
    24. RHAMM does not fulfill the criteria of an ideal target antigen for immunotherapy of acute myeloid leukemia. PMID: 22532518
    25. Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels. PMID: 23166824
    26. Hyaluronan receptors in the human ocular surface: a descriptive and comparative study of RHAMM and CD44 in tissues, cell lines and freshly collected samples. PMID: 22095138
    27. TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivo. PMID: 22371883
    28. study depicts a molecular mechanism involving BRCA1 and RHAMM that regulates apicobasal polarity and, when perturbed, may increase risk of breast cancer PMID: 22110403
    29. RHAMM/HA interaction regulates fibrosarcoma cell adhesion via the activation of FAK and ERK1/2 signaling pathways PMID: 21914806
    30. Nodular basal cell carcinoma is associated with increased levels of hyaluronic acid concomitant with upregulation of gene expression of HAS3, HYAL3 and RHAMM, when compared with normal adjacent skin. PMID: 20849445
    31. RHAMM not only represents a promising leukemia-associated antigens with specific T-cell responses in acute myeloid leukemia but, if assessed in situ on blasts, also a probable prognostic factor PMID: 21274712
    32. tumor expression can be used as a prognostic marker of gastric cancer PMID: 21435222
    33. study reports the new machinery by which RHAMM/ERK interaction induces the proliferative activity of cementifying fibroma cells via a specific signaling pathway through the CD44-EGFR axis PMID: 20956971
    34. RHAMM regulates the ciliary differentiation-promoting effect of retinoic acid on respiratory epithelial cells. PMID: 20619784
    35. coexpression of any of the CD44v with the receptor for hyaluronic acid-mediated motility (RHAMM, CD168) identifies a subgroup of DLBCL patients with a very poor prognosis, independent of the International Prognostic Index PMID: 19857547
    36. Hyaluronate receptors mediate glioma cell migration and proliferation. The expression of the HA-receptors, CD44, and RHAMM, is virtually ubiquitous amongst glioma cell lines, and glioma tumor specimens. PMID: 11716065
    37. RHAMM is an immunogenic antigen expressed in leukemias and solid tumors and might be a potential target structure for cellular immunotherapies and antibody therapies. RHAMM is not expressed in normal tissues except for testis, placenta, thymus. PMID: 12225794
    38. Increased RHAMM expression may enhance and improve the invasion and metastasis of endometrial carcinomas PMID: 12712331
    39. Augmentation of RHAMM expression within human cancers, including myeloma, can directly affect centrosomal structure and spindle integrity and potentially modulate apoptotic and cell cycle progression pathways. PMID: 15705883
    40. The overall results suggest that IHABP regulates the subcelluar localization of Bach1 in order to fine-tune transactivation of Bach1 target genes such as heme oxygenase-1. PMID: 15809329
    41. RHAMM/CD168 R3-peptide (ILSLELMKL)-specific T-cell responses in chronic myeloid leukemia [CML] patients were demonstrated; vaccination strategies inducing such RHAMM-R3-directed effector T cells might enhance specific immune responses against CML cells. PMID: 17157168
    42. an effect of CD44 on tumor cell motility may depend in part on its ability to partner with additional proteins, such as cell surface Rhamm. PMID: 17392272
    43. These data suggest that high molecular form hyaluronan is broken down by reactive oxygen species to form low-molecular-weight fragments that signal via RHAMM and RON to stimulate beat frequency. PMID: 17395888
    44. RHAMM is expressed in embryhonic stem cells (ESC) and has an important role in maintenance of ESC pluripotency and proliferation. PMID: 17872502
    45. Overexpression of HMMR is associated with breast cancer PMID: 17922014
    46. RHAMM-R3 peptide vaccination induced both immunologic and clinical responses, and therefore RHAMM constitutes a promising target for further immunotherapeutic approaches PMID: 17978170
    47. Androgen receptor regulates CD168 expression and signaling in prostate cancer PMID: 18174258
    48. The unconventional export of proteins such as RHAMM is a novel process that modifies the roles of tumor suppressors and promoters, such as BRCA1 and CD44, and might provide new targets for therapeutic intervention. PMID: 18354082
    49. Results suggested that in oral squamous cell carcinoma RHAMM expression may be correlated with tumor aggressiveness. PMID: 18425326
    50. The combined phenotype of RHAMM and p21 expression is an invaluable independent prognostic immunohistochemical profile in microsatellite instability-high colorectal cancer. PMID: 18559599

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  • 亚细胞定位：
    Cell surface. Cytoplasm. Cytoplasm, cytoskeleton, spindle.
  • 组织特异性：
    Expressed in testis. Expressed in the breast.
  • 数据库链接：

    HGNC: 5012

    OMIM: 600936

    KEGG: hsa:3161

    STRING: 9606.ENSP00000377492

    UniGene: Hs.740467