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  4. Recombinant Human Inhibitor of growth protein 3 (ING3)

Recombinant Human Inhibitor of growth protein 3 (ING3)

  • 中文名称：
    人ING3重组蛋白
  • 货号：
    CSB-YP865171HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人ING3重组蛋白
  • 货号：
    CSB-EP865171HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人ING3重组蛋白
  • 货号：
    CSB-EP865171HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人ING3重组蛋白
  • 货号：
    CSB-BP865171HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人ING3重组蛋白
  • 货号：
    CSB-MP865171HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    ING3
  • Uniprot No.：
  • 别名：
    ING3; HSPC301; Inhibitor of growth protein 3; p47ING3
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-418
  • 氨基酸序列
    MLYLEDYLEM IEQLPMDLRD RFTEMREMDL QVQNAMDQLE QRVSEFFMNA KKNKPEWREE QMASIKKDYY KALEDADEKV QLANQIYDLV DRHLRKLDQE LAKFKMELEA DNAGITEILE RRSLELDTPS QPVNNHHAHS HTPVEKRKYN PTSHHTTTDH IPEKKFKSEA LLSTLTSDAS KENTLGCRNN NSTASSNNAY NVNSSQPLGS YNIGSLSSGT GAGAITMAAA QAVQATAQMK EGRRTSSLKA SYEAFKNNDF QLGKEFSMAR ETVGYSSSSA LMTTLTQNAS SSAADSRSGR KSKNNNKSSS QQSSSSSSSS SLSSCSSSST VVQEISQQTT VVPESDSNSQ VDWTYDPNEP RYCICNQVSY GEMVGCDNQD CPIEWFHYGC VGLTEAPKGK WYCPQCTAAM KRRGSRHK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
  • 基因功能参考文献：
    1. results reveal the molecular mechanism of H3K4me3 selection by the ING3PHD and suggest that this interaction is important for mediating ING3 tumor suppressive activities. PMID: 27281824
    2. High ING3 expression is associated with prostate cancer. PMID: 26803516
    3. ING3 levels may serve as a surrogate for growth rate, and suggest possible roles for ING3 in growth and self renewal and related diseases such as cancer. PMID: 25819753
    4. Downregulated ING3 expression might play an important role in colorectal adenoma-adenocarcinoma sequence. PMID: 24927342
    5. that ING3 may be an important marker for human hepatocellular carcinoma progression and prognosis, as well as a potential therapeutic target. PMID: 22550337
    6. Data show that ING3 is degraded by the ubiquitin-proteasome pathway through the SCF(Skp2) complex. PMID: 19935701
    7. we have isolated a novel ING family gene, p47ING3, which modulates p53-mediated transcription, cell cycle control, and apoptosis. The p47ING3 gene is located at chromosome 7q31.3 and consists of 12 exons that encode 418 amino acids PMID: 12545155
    8. ING3 may be an important marker for human melanoma progression and prognosis as well as a potential therapeutic target. PMID: 17634537
    9. ING3 would function as a potential tumor suppressor molecule and that low levels of ING3 may indicate an aggressive nature of head and neck cancer. PMID: 18081876
    10. Allelic loss and reduced expression of the ING3, a candidate tumor suppressor gene at 7q31, in human head and neck cancers. PMID: 12080476

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  • 相关疾病：
    Squamous cell carcinoma of the head and neck (HNSCC)
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    ING family
  • 组织特异性：
    Expressed in brain, heart, kidney, liver, lung, ovaries, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus.
  • 数据库链接：

    HGNC: 14587

    OMIM: 275355

    KEGG: hsa:54556

    STRING: 9606.ENSP00000320566

    UniGene: Hs.489811