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  4. Recombinant Human Integrin beta-6 (ITGB6), partial

Recombinant Human Integrin beta-6 (ITGB6), partial

  • 货号：
    CSB-YP011890HU1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011890HU1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011890HU1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011890HU1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011890HU1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    ITGB6; Integrin beta-6
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation.; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1.
  • 基因功能参考文献：
    1. these findings demonstrate that JunB and CBP-mediated histone hyperacetylation are responsible for TGF-beta1 induced ITGB6 transcription in oral squamous cell carcinoma (OSCC) cells, suggesting that epigenetic mechanisms are responsible for the active transcription expression of ITGB6 induced by TGF-beta1 in OSCC cells. PMID: 29274289
    2. Taken together, our results indicate that integrin beta6 promotes tumor invasiveness in a Rac1-dependent manner and is a potential biomarker for tumor metastasis. PMID: 27440504
    3. The increased regional and distant metastasis observed in HER2+ tumors with high levels of ITGB6 might be mediated by the canonical Rho-Rac pathway through increased expression of MMP9 and MMP15. PMID: 27184932
    4. Rare missense variant c.898G>A (p.(Glu300Lys)) in ITGB6 causes not only dentogingival anomalies but also intellectual disability and alopecia. PMID: 26695873
    5. Treatment of these cells with the dual-specificity tyrosine-kinase inhibitor lapatinib led to downregulation of epithelial-to-mesenchymal transition as indicated by lower levels of SNAI1 and SNAI2 transcripts, integrin AVB6, and matrix metalloproteinase 9 protein PMID: 28349782
    6. Integrin b6 markedly promoted the proliferation and invasion of pancreatic carcinoma cells and induced ETS1 phosphorylation in an ERK-dependent manner, leading to the upregulation of matrix metalloprotease-9, which is essential for b6-mediated invasiveness of pancreatic carcinoma cells PMID: 26547582
    7. AG/GG genotypes of ITGB6 rs4665162 gene were associated with a higher risk of radiation pneumonitis (RP) in patients with lung cancer receiving radiotherapy and thus may serve as a reliable predictor of RP. PMID: 26449830
    8. A novel homozygous ITGB6 mutation causing isolated amelogenesis imperfecta, and this advances the understanding of normal and pathologic enamel development. PMID: 25431241
    9. These data reveal a novel role for Elk1 regulating ITGB6 expression and highlight how dysregulation of Elk1 can contribute to human disease. PMID: 26861876
    10. Integrin beta6 expression correlated significantly with MMP-9 expression, and may be a valuable recurrence indicator for follicular thyroid carcinomas PMID: 24844802
    11. The results indicated that MMP-9-degraded Fibronectin can adjust constituents of the avb6 heterodimers at the early phase and significantly elevate amounts of b6 integrin subunits at a later period PMID: 26134759
    12. Results shows that ITGB6 promoter contains a functional TATA box and that STAT3 and C/EBPalpha are involved in its positive regulation in oral squamous cell carcinoma cells. PMID: 25816241
    13. targeting eIF4E in integrin ava6 expressing tumors can be a potential therapeutic strategy for patients with colon cancer. PMID: 25982998
    14. In conclusion NSCLC cell lines, positive for E-Cadherin,EpCAM and avb6 expression, activate normal fibroblasts through avbeta6/TGFbeta signalling in vitro, and influence both gene expression and response to therapeutic agents. PMID: 24488011
    15. The deficiency of avb6-related hyperpermeability in T84 monolayers could be compensated by adding exogenous avb6 to the culture. PMID: 24677750
    16. Expression of the alphavbeta6 integrin subunit seems to be of pathobiological and clinical relevance in patients with non-small cell lung cancer with brain metastases. PMID: 25150423
    17. ITGB6 loss-of-function mutations cause autosomal recessive amelogenesis imperfecta. PMID: 24305999
    18. Brain metastases ITGB6 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
    19. ADAM 10 is over expressed in oral squamous cell carcinoma and contributes to invasive behaviour through a functional association with alphavbeta6 integrin PMID: 24055471
    20. Data indicate that integrin beta6, CD46, tissue factor, and chromosome 14 open reading frame 1 (C14ORF1), were identified as overexpressed on pancreatic cancer cell lines. PMID: 21934552
    21. These data identify a novel interaction between Psor and beta6 and demonstrate that it is required for alphavbeta6-dependent invasion by carcinoma cells. PMID: 21132011
    22. Integrin beta6 plays a role in the compromised wound healing associated with the diabetic state. PMID: 20854469
    23. Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8. PMID: 19920174
    24. Integrin expression in colon cancer cells is regulated by the cytoplasmic domain of the beta6 integrin subunit PMID: 11992542
    25. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema PMID: 12634787
    26. upon ligation of integrin beta6 with fibronectin, beta6 complexed with Fyn and activated it, activating a pathway leading to activation of the matrix metalloproteinase-3 gene, and promoting oral SCC cell proliferation and experimental metastasis in vivo PMID: 12917446
    27. beta(6) integrin is not normally expressed in adult native or transplanted kidneys but is commonly up-regulated in the distal tubule in disease. PMID: 15458435
    28. Constitutively activated STAT3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through ITGB6. PMID: 17438134

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  • 相关疾病：
    Amelogenesis imperfecta 1H (AI1H)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.
  • 蛋白家族：
    Integrin beta chain family
  • 数据库链接：

    HGNC: 6161

    OMIM: 147558

    KEGG: hsa:3694

    STRING: 9606.ENSP00000283249

    UniGene: Hs.470399