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  4. Recombinant Human Interleukin-13 receptor subunit alpha-2 (IL13RA2), partial

Recombinant Human Interleukin-13 receptor subunit alpha-2 (IL13RA2), partial

  • 货号：
    CSB-YP618901HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP618901HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP618901HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP618901HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP618901HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cancer/testis antigen 19; CD213a2; CT19; I13R2_HUMAN; IL-13 receptor subunit alpha-2; IL-13R subunit alpha-2; IL-13R-alpha-2; IL-13RA2; IL13 receptor; IL13BP; IL13R; Il13ra2; Interleukin 13 binding protein; Interleukin 13 receptor alpha 2 chain; Interleukin-13 receptor subunit alpha-2; Interleukin-13-binding protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4).
  • 基因功能参考文献：
    1. this study shows that tricellulin is regulated via interleukin-13-receptor alpha2, affects macromolecule uptake, and is decreased in ulcerative colitis PMID: 28612843
    2. IL-13Ralpha2 alone induces invasiveness of human glioblastoma multiforme (GBM) cells without affecting their proliferation. In contrast, in the presence of the mutant EGFR (EGFRvIII), IL-13Ralpha2 promotes GBM cell proliferation in vitro and in vivo. PMID: 29203859
    3. The results showed that IL13Ralpha2 may be used as a marker of poorer prognosis in high-grade astrocytomas, even among tumors of the same grade. PMID: 28079349
    4. TMEM219 plays a critical role in Chi3l1-induced IL-13Ralpha2 mediated signalling and tissue responses. PMID: 27629921
    5. This study shows interleukin-13 receptor alpha 2 expression could be a useful prognostic marker for selecting patients with luminal breast cancer likely to follow a clinically aggressive course despite receiving systemic therapy. PMID: 29911489
    6. Transgenic expression of IL15 is an appealing strategy to enhance CAR T-cell effector function. We tested this approach in our IL13Ralpha2-positive glioma model in which limited IL13Ralpha2-CAR T-cell persistence results in recurrence of antigen-positive gliomas. T cells were genetically modified with retroviral vectors encoding IL13Ralpha2-CARs or IL15 (IL13Ralpha2-CAR.IL15 T cells). PMID: 28550091
    7. IL-13Ralpha2 may have a role in decreased overall survival in gastric cancer after gastrectomy PMID: 27351230
    8. cigarette smoke extracts activate the PKA, CREB, and IL-13Ralpha2 axis in lung endothelial cells. PMID: 27986643
    9. High expression of IL-13Ra2 is significantly associated with the growth and metastasis of glioma cells via the Scr/PI3K/Akt/mTOR pathway. PMID: 27623944
    10. Data indicate single-chain antibody (scFv47) as a highly selective interleukin 13 receptor subunit alpha 2 (IL13Ralpha2) targeting agent. PMID: 26656559
    11. IL13Ralpha2 knockdown and IL-13 treatment cooperatively upregulated the metastasis suppressor tumor protein 63 (TP63) in a STAT6-dependent manner. PMID: 26208975
    12. Expression of CXCR3 in fibroblasts is associated with the expression of IL-13Ralpha2. PMID: 25514189
    13. In this review, we will discuss the recent advances in the IL13Ralpha2-targeted immunotherapy and evaluate the most promising strategy for targeted GBM immunotherapy. [review] PMID: 25247196
    14. Study presents evidence that PNR could promote ERalpha-negative breast cancer metastasis through activation of IL-13Ralpha2-mediated signaling pathway. PMID: 24747967
    15. In cytotoxicity assays, CAR T cells killed CAR T cells killed IL13Ra1- and/or IL13Ra2-positive cells in contrast to IL13Ra1- and IL13Ra2-negative controls PMID: 24841514
    16. IL13Ralpha2 over-expression is associated with glioma. PMID: 24204956
    17. Expression of IL-13Ralpha2 in tumors was significantly decreased with IL-13-PE treatment as compared to the controls and the number of myeloid-derived suppressor cells (MDSC) was also significantly reduced in the spleens of the IL-13-PE treated mice PMID: 23421960
    18. high expression of IL-13Ralpha2 was associated with later stages of disease progression and poor outcome in patients with colorectal cancer PMID: 22505647
    19. IL-13RALPHA2 is involved in cancer metastasis through activation of ERK/AP-1 PMID: 21858811
    20. expression of IL-13Ralpha2 prevents apoptosis and contributes to tumor growth. PMID: 21596889
    21. A novel function of histone modification in the regulation of IL-13Ralpha2 in pancreatic cancer cell lines in vitro and in vivo, was identified. PMID: 21477288
    22. Cells with high IL-13Ralpha2 expression rapidly and efficiently deplete extracellular IL-13 and could have important implications for the design and characterization of IL-13 antagonists. PMID: 21622864
    23. IL-13Ralpha2 may be an important endogenous regulator of IL-13-induced cutaneous inflammation in humans. PMID: 20971924
    24. The expression level of IL-13Ralpha2 was significantly reduced in first-recurrent glioblastomas (frGBMs) compared to primary GBMs, and significantly reduced in all untreated malignant astrocytomas compared with treated frGBMs. PMID: 20805641
    25. In eosinophil lineage-deficient IL-13 transgenic mice with eosinophilic esophagitis, IL-13-induced remodeling is significantly enhanced by IL-13Ralpha2 deletion, indicating an inhibitory effect of IL-13Ralpha2. PMID: 20543112
    26. IL-13Ralpha2-positive tumors were targeted by IL-13PE cytotoxin in vitro and in vivo in an orthotopic murine model of human pancreatic cancer. PMID: 20068108
    27. Soluble IL-13R2alpha and membrane IL-13R2alpha isoforms are both derived from the membrane form of the human receptor. An alternatively spliced sIL-13R2alpha transcript is absent in humans, compared with mice. PMID: 20007572
    28. IL-13Ralpha(345-354) (WLPFGFILI) induced a CD8(+) T-cell line that specifically produced IFN-gamma in response to HLA-A2+ T2 cells pulsed with the relevant peptide and lysed these cells. PMID: 12231526
    29. interleukin-13 receptor possibly plays an important part in the early inflammatory process of psoriasis; however, its function is lost in the psoriatic keratinocytes. PMID: 12445201
    30. IL-4/IL-13-induced IL-13Ralpha2 expression is potentiated by TNF-alpha PMID: 12485861
    31. The 5' flanking region of IL-13Ra2 has been isolated and cloned and the gene control region functionally characterized. PMID: 12816724
    32. The inhibitory effects of the IL-13 receptor alpha 2 subunit on IL-13 signaling are dependent on both the level of expression of the receptor and the concentration of IL-13. PMID: 16751396
    33. Immunohistochemical analyses revealed that 83% of ovarian cancer specimens express IL-13Ralpha2, whereas normal ovary samples expressed none or very low levels. PMID: 16902988
    34. data suggest that IL13RA2 gene polymorphisms may be involved in susceptibility to systemic sclerosis PMID: 16981293
    35. Highly variable expression of IL13Ralpha2 protein both within and across specimens of glioblastoma multiforme. PMID: 17804706
    36. IL-13Ralpha2 and Olig2 have been identified and confirmed to be interesting candidate genes whose differential expression likely plays a role in malignant progression of astrocytomas PMID: 17917751
    37. RasGRP4 translocates to varied intracellular compartments via its DAG/PMA-binding domain to regulate signaling pathways that control gene and protein expression in MCs, including the cell's ability to respond to IL-13. PMID: 18024961
    38. soluble form of IL-13Ralpha(2) may therefore modulate mucus overproduction by IL-13 through the pathway including IL-13Ralpha(1) in normal human bronchial epithelial cells PMID: 18028464
    39. IL-13R alpha 2, EphA2, and Fra-1 are attractive therapeutic targets representing molecular denominators of high-grade astrocytomas. One hundred percent of GBM tumors overexpress at least one of these proteins. PMID: 18172271
    40. 13Ralpha2 protein and mRNA are expressed to significantly higher levels in brainstem glioma than in normal brain tissue PMID: 18430795
    41. The feasibility of MRI to visualize different phases of immune response when IL-13Ralpha2-specific CTLs are administered directly to the glioma tumor bed. PMID: 18559603
    42. IL-13Ralpha2 is expressed by both primary bronchial epithelial cells and fibroblasts as an intracellular protein with a diffuse cytoplasmic distribution; in vivo, IL-13Ralpha2 is expressed in the airway mucosa mainly by bronchial epithelial cells PMID: 18564628
    43. analysis of cDNA clone and prokaryotic expression of human interleukin-13 receptor [alpha]2 chain PMID: 18677476
    44. study concludes that matrix metalloproteinase-8 cleaves IL-13R alpha 2 in vitro and contributes to the solubilization of IL-13R alpha 2 in vivo PMID: 18694590
    45. Hepatic stellate cells in sinusoidal lesions of liver from patients with nonalcoholic steatohepatitis express high levels of high-affinity IL-13R (IL-13 receptor alpha2), whereas fatty liver and normal liver specimens do not express IL-13Ralpha2. PMID: 18802068
    46. Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo. PMID: 19010904
    47. Cytokines IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha may play roles in the pathogenesis of pediatric HSP/HSPN. PMID: 19149920
    48. Human and murine neuroendocrine pheochromocytoma overexpress the IL-13Ralpha2 chain, and an IL-13PE-based receptor-directed anticancer approach may prove useful in treatment for metastatic pheochromocytoma patients. PMID: 19491224
    49. IL-13Ralpha2 may serve as a prognostic biomarker of invasion and metastasis in pancreatic cancer. PMID: 19887609
    50. Humans only express the membrane bound form of the IL-13 receptor alpha 2 PMID: 18307523

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 5 subfamily
  • 数据库链接：

    HGNC: 5975

    OMIM: 300130

    KEGG: hsa:3598

    STRING: 9606.ENSP00000243213

    UniGene: Hs.336046