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  4. Recombinant Human Interleukin-24 (IL24)

Recombinant Human Interleukin-24 (IL24)

  • 货号：
    CSB-YP613378HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP613378HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP613378HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP613378HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP613378HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    C49A; FISP; IL 24; IL 4 induced secreted protein; IL-24; IL10B; Il24; IL24_HUMAN; interleukin 24; Interleukin-24; MDA-7; MDA7; Melanocyte associated Mda 7; Melanoma differentiation association protein 7; Melanoma differentiation-associated gene 7 protein; Mob5; ST16; Suppression of tumorigenicity 16 (melanoma differentiation); Suppression of tumorigenicity 16; Suppression of tumorigenicity 16 protein
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    52-206
  • 氨基酸序列
    QEFHFGPCQ VKGVVPQKLW EAFWAVKDTM QAQDNITSAR LLQQEVLQNV SDAESCYLVH TLLEFYLKTV FKNYHNRTVE VRTLKSFSTL ANNFVLIVSQ LQPSQENEMF SIRDSAHRRF LLFRRAFKQL DVEAALTKAL GEVDILLTWM QKFYKL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
  • 基因功能参考文献：
    1. Results show that iron-induced calcification in vascular smooth muscle cells occurred via IL-24; IL-24 was increased during the calcification process induced by iron, and IL-24 itself caused calcification in the absence of iron. These results confirmed the role of interleukin-24 as a candidate gene that might contribute to calcification in vascular media cells. PMID: 29330517
    2. These results indicated that low expression of Mda-7/IL-24 along with high expression of C-myb are predictors for poor prognosis of Burkitt lymphoma patients; this outcome suggests that Mda-7/IL-24 and C-myb might be potential targets for clinical treatment of Burkitt lymphoma. PMID: 29415639
    3. Secretome analysis revealed that Oct4 upregulated interleukin 24 (IL24) expression through STAT3 and NFkappaB signaling, and siRNA against IL24 increased IRinduced senescence, whereas recombinant human IL24 suppressed it. The results of the present study indicated that Oct4 confers IR resistance on breast cancer cells by suppressing IRinduced premature senescence through STAT3- and NFkappaB-mediated IL24 production. PMID: 29749438
    4. These results suggest that hIL-24 can reverse the cisplatin (DDP)- resistance of lung cancer cells, and that the associated mechanism involves the induction of apoptosis and G2/M-phase arrest through the phosphoinositide3-kinase (PI3K)/AKT signaling pathway, as well as a decrease in drug resistance through P-gp expression PMID: 29048638
    5. These results indicated that Mda7/IL24 could induce terminal differentiation of B lymphoma cells by regulating the expression of Blimp1 and Bcl6 via altering the P38 MAPK signaling pathway. PMID: 28849038
    6. These results demonstrate a previously unrecognized role of IL24 in inhibition of translation, mediated through both phosphorylation of eIF2alpha and dephosphorylation of 4E-BP1, and provide the first direct evidence for translation control of gene-specific expression by IL24 PMID: 28461326
    7. IL-24 inhibits AKT via regulating the HMGA1/miR-222 signaling node in human lung cancer cells and acts as an effective tumor suppressor. PMID: 27602961
    8. this paper shows that IL-24 represents a potential biomarker of allergic inflammation and a Th2 polarized condition of the epithelium PMID: 26577568
    9. Low IL24 expression is associated with endometriosis. PMID: 27624484
    10. IL-20 and IL-24 increased the production of monocyte chemoattractant protein-1 by activated spondyloarthritis synovial fluid monocytes, decreased the production of Dickkopf-1 by SpA fibroblast-like synovial cells and induced mineralization in human osteoblasts; taken together, findings indicate disease-aggravating functions of IL-20 and IL-24 in spondyloarthritis PMID: 28369789
    11. a novel pathway for mda-7/IL-24-induced caspase-independent apoptosis in neuroblastoma cells mediated through modulation of AIF, ATM, and gamma-H2AX. PMID: 27197168
    12. mda-7/IL-24 directly regulates miRNA expression in cancer cells and highlights the novelty of the mda-7/IL-24-miR-221-beclin-1 loop in mediating cancer cell-specific death. PMID: 27940575
    13. LINC00152-mediated oncogenic effects occur in part through the epigenetic silencing of IL24 expression following binding with EZH2. PMID: 28109288
    14. mechanistic studies, inhibition of SRC and PKCdelta completely ablated the ability of MDA-7/IL-24 to reduce the Bcl-x(L)/(s) mRNA ratio and cell viability. These findings show that Bcl-x(s) expression is an important mediator of MDA-7/IL-24-induced cytotoxicity requiring the SRC/PKCdelta signaling axis in NSCLC cells. PMID: 27519412
    15. Expression of IL-24 and IGFBP-3 significantly suppressed prostate cancer tumor growth in vivo. PMID: 26323436
    16. Results suggest that IL-24 exerts a potent suppressive effect on influenza viral replication and can be used in the treatment of influenza infection. PMID: 27687232
    17. Expression of IL-24 enhanced the sensitivity of B lymphoma cells to chemotherapy agents by altering the expression of multidrug-resistance genes via downregulating GTP-RhoA-ERK signaling pathway PMID: 26883473
    18. IL20R1 correlated with prognosis of patients with pancreatic cancer, and mediates pancreatic cancer cell growth and migration. It may be a potential biomarker for IL24 molecular-targeted therapy. PMID: 26977011
    19. The anti-viral effect of IL-24 correlated with caspase-3 activation and could be blocked by a pan-caspase inhibitor and by small interfering RNA (siRNA) directed towards TLR3. PMID: 26367324
    20. This study demonstrated that IL-19 and IL-24 are associated with the modulation of T-cell responses in filarial infections. PMID: 26486636
    21. This study indicates that IL-24 upregulates expression and activation of double-stranded RNA-activated protein kinase, further increasing expression and activation of eIF-2alpha, and decreasing Bcl-2 to promote apoptosis. PMID: 26168134
    22. The association of IL-24 polymorphisms with metabolic and cardiovascular risk factors. PMID: 24552169
    23. Data show that Adenovirus-mediated interleukin 24 (Ad-IL-24) gene therapy suppresses growth of lung carcinoma cells SPC-A1 both in vitro and in vivo. PMID: 25479732
    24. gene transfer to drive IL24 expression in chronic myeloid leukemia cell lines resulted in cytotoxicity specifically to cancer cells. PMID: 26097559
    25. IL-24 may enhance tumor chemosensitivity to cisplatin. PMID: 25778843
    26. MDA-7/IL-24 inhibits Nrf2-mediated antioxidant response through activation of p38 pathway and inhibition of ERK pathway involved in cancer cell apoptosis. PMID: 25236495
    27. High expression of IL-24 was significantly correlated with second primary malignancy indicator in head and neck squamous cell carcinoma. PMID: 25091574
    28. Distribution of interleukin-10 family cytokines in serum and synovial fluid of patients with inflammatory arthritis reveals different PMID: 25178435
    29. IL-24 has a role in sensitizing melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways PMID: 20216471
    30. The results suggest that IL-24 can induce neuroblastoma cell differentiation and apoptosis and may be a potential therapeutic agent for neuroblastoma. PMID: 23692552
    31. MDA-7/IL-24: multifunctional cancer killing cytokine. PMID: 25001534
    32. elevated gene expression in Mexican mestizo patients with active Crohn's disease PMID: 24527982
    33. These results suggest a possible contribution of IL-24 to squamous cell carcinoma invasion via enhancing focal expression of MMP7. PMID: 24270662
    34. We found that IL-24 effectively inhibits SH-SY5Y neuroblastoma cell migration and invasion by changing subcellular localization and cellular levels of beta-catenin and regulating the levels of proteins associated with cell migration and invasion PMID: 24084981
    35. a novel MDA-7/IL-24-GAS3-beta1integrin-fibronectin signaling pathway that suppresses breast cancer growth, is reported. PMID: 23468528
    36. this study indicates that overexpression of IL-24 gene can significantly promote chemosensitivity in MDR phenotype SGC7901/CDDP gastric cancer cells. PMID: 23982423
    37. MDA-7/IL-24 has a role in cancer-specific apoptosis through SARI induction PMID: 24282278
    38. mediates T cell microvesicles-induced mast cell activation; contributes to T cell-mediated skin inflammation PMID: 23768573
    39. MDA-7/IL-24 overexpression decreased the expression of CD44. PMID: 23722307
    40. IL-24 was strongly expressed in human psoriatic epidermis. Pharmacological inhibition of NF-kappaB increased IL-24 expression in TNF-stimulated human primary keratinocytes. PMID: 24211183
    41. The role of mda-7/IL-24 is inhibits decreasing of adhesion and invasion in vitro, blocking cell cycle, down-regulating the expression of ICAM-1, MMP-2/9, CDK1, the phosphorylation of ERK and Akt, NF-kappaB and AP-1 transcription activity. PMID: 23772146
    42. Our findings demonstrate that MDA-7/IL-24 is be a safe and effective way to eradicate cancers and also potentially establish disease-free survival PMID: 23720015
    43. This suggests that IL-24 plays a profound role in suppressing tumour lymphangiogenesis, thereby, reducing the likelihood of cancer metastasis via the lymphatic route. PMID: 23546515
    44. results demonstrate that the inflammatory cytokines TNFalpha and IL24 are direct targets of miR-203 in keratinocytes PMID: 22917968
    45. Data suggest that IL24 is ubiquitinated and degraded by 26S proteasomes; data from site-directed mutagenesis study suggest that lysine 123 is the major internal lysine involved in ubiquitination of IL24; K123R mutant promotes apoptosis of HeLa cells. PMID: 23078624
    46. IL-24 appears to promote wound chronicity via its inhibitory effect on the migratory behavior of human keratinocytes, mediated through an AKT-dependent pathway. PMID: 23110359
    47. this study may provide a novel mechanism of action of IL-24 in cardiovascular disease and indicates that IL-24 is a potential therapeutic agent in VSMC calcification. PMID: 23063979
    48. IL-24 produced by maternal-fetal interface in human first trimester pregnancy may influence the invasion of trophoblasts and is involved in normal pregnancy. PMID: 18704311
    49. IL-24 could activate human CD8(+) T cells, driving CD8(+) T cells to produce interferon-gamma (IFN-gamma) and counteract tuberculosis. PMID: 21787878
    50. Transduction of murine tumors with adenoviruses expressing the human IL-24 gene however suppressed the viability and decreased the tumor growth PMID: 22475191

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-10 family
  • 组织特异性：
    Up-regulated in melanoma cells induced to terminally differentiate.
  • 数据库链接：

    HGNC: 11346

    OMIM: 604136

    KEGG: hsa:11009

    STRING: 9606.ENSP00000375795

    UniGene: Hs.58831