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  4. Recombinant Human Intracellular hyaluronan-binding protein 4 (HABP4)

Recombinant Human Intracellular hyaluronan-binding protein 4 (HABP4)

  • 货号：
    CSB-YP683363HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP683363HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP683363HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP683363HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP683363HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    HABP4
  • Uniprot No.：
  • 别名：
    HABP4; Intracellular hyaluronan-binding protein 4; IHABP-4; IHABP4; Hyaluronan-binding protein 4; Ki-1/57 intracellular antigen
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-413
  • 氨基酸序列
    MKGALGSPVA AAGAAMQESF GCVVANRFHQ LLDDESDPFD ILREAERRRQ QQLQRKRRDE AAAAAGAGPR GGRSPAGASG HRAGAGGRRE SQKERKSLPA PVAQRPDSPG GGLQAPGQKR TPRRGEQQGW NDSRGPEGML ERAERRSYRE YRPYETERQA DFTAEKFPDE KPGDRFDRDR PLRGRGGPRG GMRGRGRGGP GNRVFDAFDQ RGKREFERYG GNDKIAVRTE DNMGGCGVRT WGSGKDTSDV EPTAPMEEPT VVEESQGTPE EESPAKVPEL EVEEETQVQE MTLDEWKNLQ EQTRPKPEFN IRKPESTVPS KAVVIHKSKY RDDMVKDDYE DDSHVFRKPA NDITSQLEIN FGNLPRPGRG ARGGTRGGRG RIRRAENYGP RAEVVMQDVA PNPDDPEDFP ALS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates DNA-binding activity of the transcription factor MEF2C in myocardial cells in response to mechanical stress. Plays a role in pre-mRNA splicing regulation. Binds (via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step. Seems to play a role in PML-nuclear bodies formation.
  • 基因功能参考文献：
    1. Ki-1-57 is a target of sumoylation and affects pml nuclear body formation. PMID: 28695742
    2. Ki-1/57 may be involved in translational regulation PMID: 21771594
    3. Ki-1/57 is localized to several subnuclear domains, all of which have been described to splicing and other RNA processing events. PMID: 20436279
    4. interacts with the C-terminal region of the human chromatin-remodeling factor CHD-3 PMID: 12505151
    5. association of Ki-1/57 with the RACK1/PKC pathway and may be important for the regulation of its cellular functions PMID: 14699138
    6. MEF2C DNA-binding activity is inhibited through its interaction with Ki-1/57. PMID: 15862299
    7. Has two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by PRMT1. PMID: 16879614
    8. Data suggest that Ki-1/57 has characteristics of an intrinsically unstructured protein, which may explain its functional plasticity. PMID: 18788774
    9. Findings suggest that Ki-1/57 is probably involved in cellular events related to RNA functions, such as pre-mRNA splicing. PMID: 19523114

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, Stress granule. Cytoplasm, sarcoplasm. Nucleus, nuclear body. Nucleus, nucleolus. Nucleus speckle. Nucleus, Cajal body. Nucleus, gem.
  • 组织特异性：
    Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes.
  • 数据库链接：

    HGNC: 17062

    OMIM: 617369

    KEGG: hsa:22927

    STRING: 9606.ENSP00000364398

    UniGene: Hs.494567