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  4. Recombinant Human Iodotyrosine dehalogenase 1 (IYD), partial

Recombinant Human Iodotyrosine dehalogenase 1 (IYD), partial

  • 货号：
    CSB-YP754272HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP754272HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP754272HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP754272HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP754272HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    IYD; C6orf71; DEHAL1; Iodotyrosine deiodinase 1; IYD-1; EC 1.21.1.1; Iodotyrosine dehalogenase 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
  • 基因功能参考文献：
    1. The rate-limiting processes that contribute to the ability of flavin to promote reductive dehalogenation in human IYD. PMID: 26151430
    2. A switch between one- and two-electron chemistry of iodotyrosine deiodinase is controlled by substrate. PMID: 25395621
    3. Iodotyrosine deiodinase defect identified via genome-wide approach. PMID: 22535972
    4. high activity of human saliva peroxidase with iodide as a substrate may play a crucial role in the bioavailability and metabolism of biologically active iodide. PMID: 21870604
    5. Mutations in DEHAL1 leads to hypothyroidism, goiter and mental retardation (Review) PMID: 20298747
    6. molecular cloning and investigation of the localization and activity of DEHAL1 PMID: 15289438
    7. the cytoplasmic tail of DEHAL1 could play a role in the stability of the protein PMID: 16910871
    8. Diffuse cytoplasmatic localisation or downregulation of DEHAL1 expression in thyroid cancers suggests alteration or loss of DEHAL1 function during thyroid cell dedifferentiation. PMID: 17322488
    9. homozygous mutations in DEHAL1 appear to cause human iodotyrosine deiodinase deficiency, leading to hereditary hypothyroidism and goiter PMID: 18434651
    10. This study describes a functional mutation within IYD, demonstrating the molecular basis of the iodine wasting form of congenital hypothyroidism PMID: 18765512

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  • 相关疾病：
    Thyroid dyshormonogenesis 4 (TDH4)
  • 亚细胞定位：
    Cell membrane; Single-pass membrane protein. Cytoplasmic vesicle membrane.
  • 蛋白家族：
    Nitroreductase family
  • 组织特异性：
    Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
  • 数据库链接：

    HGNC: 21071

    OMIM: 274800

    KEGG: hsa:389434

    STRING: 9606.ENSP00000229447

    UniGene: Hs.310225