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  4. Recombinant Human Iron-sulfur protein NUBPL (NUBPL)

Recombinant Human Iron-sulfur protein NUBPL (NUBPL)

  • 中文名称：
    人NUBPL重组蛋白
  • 货号：
    CSB-YP819450HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人NUBPL重组蛋白
  • 货号：
    CSB-EP819450HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人NUBPL重组蛋白
  • 货号：
    CSB-EP819450HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人NUBPL重组蛋白
  • 货号：
    CSB-BP819450HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人NUBPL重组蛋白
  • 货号：
    CSB-MP819450HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    NUBPL
  • Uniprot No.：
  • 别名：
    C14orf127; FLJ12660; huInd1; IND1 homolog; Iron-sulfur protein NUBPL; Nubpl; NUBPL_HUMAN; nucleotide binding protein like; Nucleotide-binding protein-like
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    39-319
  • 氨基酸序列
    GA GSETLKQRRT QIMSRGLPKQ KPIEGVKQVI VVASGKGGVG KSTTAVNLAL ALAANDSSKA IGLLDVDVYG PSVPKMMNLK GNPELSQSNL MRPLLNYGIA CMSMGFLVEE SEPVVWRGLM VMSAIEKLLR QVDWGQLDYL VVDMPPGTGD VQLSVSQNIP ITGAVIVSTP QDIALMDAHK GAEMFRRVHV PVLGLVQNMS VFQCPKCKHK THIFGADGAR KLAQTLGLEV LGDIPLHLNI REASDTGQPI VFSQPESDEA KAYLRIAVEV VRRLPSPSE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits.
  • 基因功能参考文献：
    1. huInd1 binds to the untranslated region of the TEM-1 mRNA at 3' site and thereby reducing the possibility of its endonucleolytic cleavage, resulting in over-expression of TEM-1. PMID: 25240856
    2. Inhibition of ERK suppressed the NUBPL-induced changes in EMT and cell motility. PMID: 28346728
    3. Our data show that NUBPL mutations are associated with a unique, consistent, and recognizable MRI pattern. PMID: 23553477
    4. Mutations in NUBPL is associated with complex I deficiency. PMID: 20818383
    5. These data identify huInd1 as a new assembly factor for human respiratory complex I with a possible role in the delivery of one or more Fe/S clusters to complex I subunits.[Ind1] PMID: 19752196

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  • 相关疾病：
    Mitochondrial complex I deficiency (MT-C1D)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Mrp/NBP35 ATP-binding proteins family
  • 组织特异性：
    Highest expression in liver and kidney. expressed at significant levels in small intestine and brain (at protein level).
  • 数据库链接：

    HGNC: 20278

    OMIM: 252010

    KEGG: hsa:80224

    STRING: 9606.ENSP00000281081

    UniGene: Hs.288981