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  4. Recombinant Human Iroquois-class homeodomain protein IRX-1 (IRX1)

Recombinant Human Iroquois-class homeodomain protein IRX-1 (IRX1)

  • 中文名称：
    人IRX1重组蛋白
  • 货号：
    CSB-YP011833HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    人IRX1重组蛋白
  • 货号：
    CSB-EP011833HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    人IRX1重组蛋白
  • 货号：
    CSB-EP011833HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    人IRX1重组蛋白
  • 货号：
    CSB-BP011833HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    人IRX1重组蛋白
  • 货号：
    CSB-MP011833HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    IRX1
  • Uniprot No.：
  • 别名：
    IRX1; IRXA1; Iroquois-class homeodomain protein IRX-1; Homeodomain protein IRXA1; Iroquois homeobox protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-480
  • 氨基酸序列
    MSFPQLGYPQ YLSAAGPGAY GGERPGVLAA AAAAAAAASS GRPGAAELGG GAGAAAVTSV LGMYAAAGPY AGAPNYSAFL PYAADLSLFS QMGSQYELKD NPGVHPATFA AHTAPAYYPY GQFQYGDPGR PKNATRESTS TLKAWLNEHR KNPYPTKGEK IMLAIITKMT LTQVSTWFAN ARRRLKKENK VTWGARSKDQ EDGALFGSDT EGDPEKAEDD EEIDLESIDI DKIDEHDGDQ SNEDDEDKAE APHAPAAPSA LARDQGSPLA AADVLKPQDS PLGLAKEAPE PGSTRLLSPG AAAGGLQGAP HGKPKIWSLA ETATSPDGAP KASPPPPAGH PGAHGPSAGA PLQHPAFLPS HGLYTCHIGK FSNWTNSAFL AQGSLLNMRS FLGVGAPHAA PHGPHLPAPP PPQPPVAIAP GALNGDKASV RSSPTLPERD LVPRPDSPAQ QLKSPFQPVR DNSLAPQEGT PRILAALPSA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Multiple evidences suggested that PRMT5 repressed transcription of tumor suppressor IRX1 via recruitment of DNMT3A on promoter. PMID: 29802960
    2. A total of three nonsynonymous mutations (p.Gln240Glu, p.Ser298Asn and p.Ala381Glu) of the IRX1 gene were verified in 215 nonsyndromic congenital heart disease patients. PMID: 28358424
    3. this is the first genome-wide association study of Rheumatoid Factor positivity in Rheumatoid Arthritis. Variation at the IRX1 locus on chromosome 5p15.3 is associated with the presence of Rheumatoid Factor. Our findings indicate that IRX1 and HLA-DRB1 are the strongest genetic factors for Rheumatoid Factor production in Rheumatoid Arthritis. PMID: 26815016
    4. In osteosarcoma cells and lines, IRX1 overexpression was associated with hypomethylation of its own promoter. Experimental modulation in cell lines altered migration, invasion, and resistance to anoikis in vitro, and influenced lung metastasis in mice. PMID: 25822025
    5. Findings suggest that methylation-associated down-regulation of EBF3 and IRX1 genes may play an important role in a pathogenic effect of TGF-beta on RASFs. PMID: 23456299
    6. Helicobacter pylori infection contributes to IRX1 promoter methylation in gastric mucosa. PMID: 21649733
    7. enforcing IRX1 expression effectively suppresses peritoneal spreading and pulmonary metastasis via anti-angiogenesis and anti-VM mechanisms, in addition to previously found cell growth and invasion. PMID: 21602894
    8. IRX1 could potentially serve as a biomarker for gastric cancer. PMID: 20440264
    9. Results verify IRX1, EBF3, SLC5A8, SEPT9, and FUSSEL18 as valid methylation markers in two separate sets of HNSCC specimens; also preliminarily show a trend between HPV16 positivity and target gene hypermethylation of IRX1, EBF3, SLC5A8, and SEPT9. PMID: 20029986
    10. Homeobox gene IRX1 is a tumor suppressor gene in gastric carcinoma. PMID: 20440264
    11. Frequent methylation of IRX1 gene is associated with head and neck squamous cell carcinoma PMID: 18559491

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/IRO homeobox family
  • 数据库链接：

    HGNC: 14358

    OMIM: 606197

    KEGG: hsa:79192

    STRING: 9606.ENSP00000305244

    UniGene: Hs.424156